{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:07:02Z","timestamp":1788876422680,"version":"build-2803163510"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011478","name":"Foshan Science and Technology Bureau","doi-asserted-by":"publisher","award":["2520001003269"],"award-info":[{"award-number":["2520001003269"]}],"id":[{"id":"10.13039\/501100011478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Guangzhou Federation of Social Sciences","doi-asserted-by":"publisher","award":["ZKKYYB202503"],"award-info":[{"award-number":["ZKKYYB202503"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study presents the rational design and application of engineered metal\u2013organic framework (MOF) hybrids, tailored to exhibit accelerated electron transfer kinetics and enhanced molecular recognition capabilities for the high-sensitivity detection of dopamine (DA). Specifically, an enzyme-free electrochemical sensing platform was constructed using Au@Co-MOF nanocomposites, which were synthesized via a controllable in situ growth approach. Au nanoparticles (AuNPs) were uniformly anchored onto the [Co3(TMA)3(H2O)5]n (where TMA = 1,3,5-trimesic acid) framework containing coordinatively unsaturated Co(II) active sites, forming the Au@Co-MOF hybrid material. Field-emission scanning electron microscopy (FESEM) characterization confirmed that the Au@Co-MOF hybrids possessed a well-defined spherical morphology with an average particle size of 7.5 \u03bcm, in clear contrast to the discrete AuNPs used for modification. The electrochemical sensing performance of the Au@Co-MOF-modified platform was systematically evaluated via differential pulse voltammetry (DPV) under optimized experimental conditions. Results demonstrated that the sensor exhibited a wide linear response range for DA, with a low limit of detection (LOD, S\/N = 3) of 0.02 \u03bcM and a high sensitivity of 2.0 \u03bcA\u00b7\u03bcM\u20131\u00b7cm\u20132. Moreover, the proposed sensor exhibited superior selectivity and excellent stability. Its practical applicability was further confirmed through the successful determination of DA in biological matrices (urine and serum), with high recovery rates of 95.5%\u2013104.8% (serum) and 102.8%\u2013104.5% (urine). These results underscore the great potential of the Au@Co-MOF-modified screen-printed electrode (SPE) enzyme-free platform as a robust, sensitive, and selective electrochemical sensor for neurochemical monitoring.<\/jats:p>","DOI":"10.1021\/acsomega.6c03355","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:08:00Z","timestamp":1787616480000},"page":"52607-52617","source":"Crossref","is-referenced-by-count":0,"title":["Rational Design\nof Au@co-MOF Synergistic Platform\nfor Ultrasensitive Monitoring of Dopamine in Human Biological Fluids"],"prefix":"10.1021","volume":"11","author":[{"given":"Feng","family":"Zhou","sequence":"first","affiliation":[{"name":"Guangzhou College of Technology and Business , , ,","place":["Guangzhou, Guangdong, China, 510850"]},{"name":"Universiti Putra Malaysia , , ,","place":["Serdang, Selangor, Malaysia, 43400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Ngee","family":"Lim","sequence":"additional","affiliation":[{"name":"Universiti Putra Malaysia , , ,","place":["Serdang, Selangor, Malaysia, 43400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Izwaharyanie","sequence":"additional","affiliation":[{"name":"Universiti Putra Malaysia , , ,","place":["Serdang, Selangor, Malaysia, 43400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Tao","sequence":"additional","affiliation":[{"name":"Guangzhou College of Technology and Business , , ,","place":["Guangzhou, Guangdong, China, 510850"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou College of Technology and Business , , ,","place":["Guangzhou, Guangdong, China, 510850"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangzhou College of Technology and Business , , ,","place":["Guangzhou, Guangdong, China, 510850"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2565-1971","authenticated-orcid":true,"given":"Xiongtao","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangzhou College of Technology and Business , , ,","place":["Guangzhou, Guangdong, China, 510850"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"issue":"4","key":"2026090809104160000_cit1","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1021\/jacs.2c07053","article-title":"Conductive Metal\u2013Organic\nFramework Microelectrodes Regulated\nby Conjugated Molecular Wires for Monitoring of Dopamine in the Mouse\nBrain","volume":"145","author":"Wang","year":"2023","journal-title":"J. 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Alloys Compd."},{"key":"2026090809104160000_cit32","doi-asserted-by":"publisher","first-page":"114541","DOI":"10.1016\/j.jelechem.2020.114541","article-title":"Synthesis of hierarchical\nporous ZIF-8\/3DCNTs composite sensor for ultrasensitive detection\nof DA and DFT studies","volume":"878","author":"Fan","year":"2020","journal-title":"J. Electroanal. Chem."},{"key":"2026090809104160000_cit33","doi-asserted-by":"publisher","first-page":"144766","DOI":"10.1016\/j.electacta.2024.144766","article-title":"Facile electrodeposition\nof CoMn2O4 nanoparticles on nickel foam as an electrode material for\nsupercapacitors","volume":"501","author":"Emin","year":"2024","journal-title":"Electrochim. 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