{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:25:09Z","timestamp":1786465509199,"version":"build-2736575974"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["CPP2022-009967"],"award-info":[{"award-number":["CPP2022-009967"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2021-126445OB-I00"],"award-info":[{"award-number":["PID2021-126445OB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2023-150047OA-I00"],"award-info":[{"award-number":["PID2023-150047OA-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["RyC2021-03447-I"],"award-info":[{"award-number":["RyC2021-03447-I"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Controlling the diameter of electrospun polymeric nanofibers is essential for optimizing their performance in localized drug delivery applications. In this context, mathematical models able to use processing parameters to predict nanofiber dimensions remain limited. In this work, a series of polycaprolactone nanofibers synthesized across a wide diameter range (727\u20132925 nm) were initially fabricated by the electrospinning method to be subsequently evaluated for localized drug release applications. The nanofiber diameter was systematically varied by adjusting the flow rate and the solvent composition during nanofiber fabrication, while keeping the polymer mass constant. After that, three-dimensional response-surface models were developed, revealing a logarithmic dependence of the nanofiber diameter on the flow rate and an inverse dependence on the solvent ratio. Importantly, both the polymer mass flux through the Taylor cone and the solution viscosity were found to be derived variables, rather than independent, governed by the flow rate and solvent composition, respectively. To connect nanofiber fabrication with drug delivery performance, ferulic acid was selected as a model bioactive compound, and it was incorporated into the nanofibers at three loading levels (0.5, 2, and 6 wt %). Release studies, monitored by high-performance liquid chromatography and ultraviolet\u2013visible spectroscopy, showed that the release behavior was strongly dependent on the ferulic acid content and on the electrospinning processing conditions, whereas no direct dependence on the nanofiber diameter alone was observed. Finally, a kinetic analysis using Higuchi, Peppas\u2013Sahlin, and first-order models revealed that a purely diffusive mechanism does not apply. Instead, the release follows either a first-order or a Peppas\u2013Sahlin model depending on the flow rate used during fabrication. These findings demonstrate that the processing parameters that govern nanofiber diameter also control the internal drug distribution and, consequently, the release kinetics, providing a unified framework for the rational design of electrospun drug delivery systems.<\/jats:p>","DOI":"10.1021\/acsomega.6c03403","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T04:57:44Z","timestamp":1785128264000},"page":"46252-46267","source":"Crossref","is-referenced-by-count":0,"title":["Three-Dimensional\nResponse-Surface Models to Predict\nthe Diameter of Electrospun Polycaprolactone Nanofibers: Application\nin the release of ferulic acid"],"prefix":"10.1021","volume":"11","author":[{"given":"Felipe","family":"Lesto\u0301n-Cabeo","sequence":"first","affiliation":[{"name":"University of Almeri\u0301a , , ,","place":["Almeri\u0301a, Spain, 04120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Mun\u0303oz-Flores","sequence":"additional","affiliation":[{"name":"University of Almeri\u0301a , , ,","place":["Almeri\u0301a, Spain, 04120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Olmedo-Navarro","sequence":"additional","affiliation":[{"name":"University of Almeri\u0301a , , ,","place":["Almeri\u0301a, Spain, 04120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5510-6297","authenticated-orcid":true,"given":"Francisco M.","family":"Arrabal-Campos","sequence":"additional","affiliation":[{"name":"University of Almeri\u0301a , , ,","place":["Almeri\u0301a, Spain, 04120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-580X","authenticated-orcid":true,"given":"Ignacio","family":"Ferna\u0301ndez","sequence":"additional","affiliation":[{"name":"University of Almeri\u0301a , , ,","place":["Almeri\u0301a, Spain, 04120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6313-2340","authenticated-orcid":true,"given":"Rafael","family":"Contreras-Ca\u0301ceres","sequence":"additional","affiliation":[{"name":"University of Almeri\u0301a , , ,","place":["Almeri\u0301a, Spain, 04120"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"issue":"1","key":"2026081110113663300_cit1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/adhm.201100021","article-title":"Electrospun Nanofibers for Regenerative\nMedicine","volume":"1","author":"Liu","year":"2012","journal-title":"Adv. Healthcare Mater."},{"issue":"22","key":"2026081110113663300_cit2","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.2174\/138161208785740180","article-title":"Nanotechnology\nfor Nanomedicine and\nDelivery of Drugs","volume":"14","author":"Venugopal","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"2026081110113663300_cit3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.31487\/j.DOBCR.2021.02.04","article-title":"Effect of Electrospinning\nParameters on the Fiber Diameter and Morphology of PLGA Nanofibers","volume":"4","author":"Duan","year":"2021","journal-title":"Dent. Oral Biol. Craniofacial Res."},{"issue":"3","key":"2026081110113663300_cit4","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.biotechadv.2010.01.004","article-title":"Electrospinning:\nA Fascinating Fiber Fabrication Technique","volume":"28","author":"Bhardwaj","year":"2010","journal-title":"Biotechnol.\nAdv."},{"issue":"4","key":"2026081110113663300_cit5","doi-asserted-by":"publisher","first-page":"656","DOI":"10.3390\/nano9040656","article-title":"Electrospun\nNanofibers: Recent Applications in Drug Delivery and Cancer Therapy","volume":"9","author":"Contreras-Ca\u0301ceres","year":"2019","journal-title":"Nanomaterials"},{"issue":"15","key":"2026081110113663300_cit6","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1016\/S0266-3538(03)00178-7","article-title":"A Review on\nPolymer Nanofibers by Electrospinning and Their Applications in Nanocomposites","volume":"63","author":"Huang","year":"2003","journal-title":"Compos. Sci. 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Colloid Interface Sci."},{"issue":"12","key":"2026081110113663300_cit31","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1111\/j.2042-7158.2010.01190.x","article-title":"Therapeutic Potential\nof Argan Oil: A Review","volume":"62","author":"Monfalouti","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"issue":"4","key":"2026081110113663300_cit32","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1080\/11263504.2016.1190418","article-title":"Phytochemical Analysis\nand Antibacterial Activity towards Methicillin-Resistant Staphylococcus\nAureus of Leaf Extracts from Argania spinosa (L.)\nSkeels","volume":"151","author":"Bonvicini","year":"2017","journal-title":"Plant Biosyst."},{"key":"2026081110113663300_cit33","doi-asserted-by":"publisher","first-page":"114528","DOI":"10.1016\/j.jep.2021.114528","article-title":"Ethnobotany,\nPhytochemistry and Biological Properties of Argan Tree (Argania spinosa (L.) Skeels) (Sapotaceae) - A Review","volume":"281","author":"Mechqoq","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"15","key":"2026081110113663300_cit34","doi-asserted-by":"publisher","first-page":"5182","DOI":"10.1021\/ie071452o","article-title":"Aqueous Solubility\nof Some Natural Phenolic Compounds","volume":"47","author":"Mota","year":"2008","journal-title":"Ind. Eng.\nChem. Res."},{"issue":"12","key":"2026081110113663300_cit35","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.4314\/tjpr.v15i12.5","article-title":"Biological Activities and Phenolic Contents of Argania\nSpinosa L (Sapotaceae) Leaf Extract","volume":"15","author":"Dakiche","year":"2017","journal-title":"Trop. J.\nPharm. 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Coat."},{"issue":"1","key":"2026081110113663300_cit42","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/pharmaceutics18010047","article-title":"Waterproof Fabric with Copper Ion-Loaded\nMulticompartmental Nanoparticle Coatings for Jellyfish Repellency","volume":"18","author":"Wang","year":"2026","journal-title":"Pharmaceutics"},{"issue":"6","key":"2026081110113663300_cit43","doi-asserted-by":"publisher","DOI":"10.1002\/open.202500564","article-title":"Core\u2013Sheath\nNanofibers From a Modified Coaxial Electrospinning for Transdermal\nDelivery of Finasteride","volume":"15","author":"Sun","year":"2026","journal-title":"ChemistryOpen"},{"issue":"3","key":"2026081110113663300_cit44","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3390\/biom16030363","article-title":"Electrospun PLA\/PVP K90 Biphasic-Release Sublingual Film for Motion\nSickness Treatment","volume":"16","author":"Zhang","year":"2026","journal-title":"Biomolecules"},{"issue":"7","key":"2026081110113663300_cit45","doi-asserted-by":"publisher","first-page":"795","DOI":"10.3390\/polym18070795","article-title":"Fast Dissolving\nResveratrol\u2013Polyvinylpyrrolidone\nNanofibrous Films Fabricated in Bulk Using a Special Hole Electrospinning\nTechnique","volume":"18","author":"Guo","year":"2026","journal-title":"Polymers"},{"key":"2026081110113663300_cit46","doi-asserted-by":"publisher","first-page":"176198","DOI":"10.1016\/j.cej.2026.176198","article-title":"One-Step\nBatch Fabrication of Zn-Co ZIFs@TiO2 Nanofibers via Modified\nTriaxial Electrospinning for Enhanced Photocatalytic Antibiotic Degradation\nthrough Peroxymonosulfate Activation","volume":"536","author":"Wang","year":"2026","journal-title":"Chem.\nEng. J."},{"key":"2026081110113663300_cit47","doi-asserted-by":"publisher","first-page":"214808","DOI":"10.1016\/j.bioadv.2026.214808","article-title":"Comparative\nStudy of Bio-Based and Synthetic Phase Change Materials Functionalized\nCoaxial Fibers for Photothermal-Controlled Drug Delivery","volume":"184","author":"Zhou","year":"2026","journal-title":"Biomater. 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