{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:13:20Z","timestamp":1788437600979,"version":"build-2803163510"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1112258"],"award-info":[{"award-number":["1112258"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018822","name":"Western Sydney University","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100018822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Reactive species chemistry, encompassing both broad-spectrum reactive oxygen species (ROS) and reactive nitrogen species (RNS), has received significant attention in cancer therapeutics due to its capacity to induce severe oxidative damage and subsequent cancer cell death. Here in this study, we developed M1 macrophage membrane-coated MnO2-silica containing doxorubicin (DOX) and NO donor (M1@MS\/MnO2\/DOX\/NO) for the combination of reactive species, including both ROS and RNS for hepatocellular carcinoma therapy. Specifically, superoxide anion O2\u2022\u2013 produced from DOX could react with NO to form ONOO\u2013 for RNS-mediated treatment. Meanwhile, Mn2+ produced from the MnO2 layer under a reductive microenvironment could function as a catalyst to transform endogenous H2O2 into the highly toxic \u2022OH to achieve ROS-mediated treatment. Our results demonstrated that this novel combination of reactive species therapy synergistically improved the therapeutic efficiency against liver cancer cells, and showed a significant reduction of cancer cell proliferation and in vivo tumor growth.<\/jats:p>","DOI":"10.1021\/acsomega.6c04069","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T21:01:46Z","timestamp":1787259706000},"page":"51215-51225","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic ROS\/RNS-Mediated\nChemotherapy via M1 Macrophage\nMembrane-Functionalized Nanovesicles for Targeted Hepatocellular Carcinoma\nTreatment"],"prefix":"10.1021","volume":"11","author":[{"given":"Jiangyu","family":"Li","sequence":"first","affiliation":[{"name":"Nantong University , , ,","place":["Nantong, China, 226019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Du","sequence":"additional","affiliation":[{"name":"Nantong University , , ,","place":["Nantong, China, 226019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehao","family":"Mao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nantong University , , ,","place":["Nantong, China, 226001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyu","family":"Guan","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Nantong University , , ,","place":["Nantong, China, 226001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Nantong University , , ,","place":["Nantong, China, 226019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9058-2643","authenticated-orcid":true,"given":"Tianqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Western Sydney University , , , ,","place":["Penrith, NSW, Australia, 2751"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4959-9790","authenticated-orcid":true,"given":"Qiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Nantong University , , ,","place":["Nantong, China, 226019"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"1","key":"2026090307191729000_cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat.\nRev. Dis. Primers"},{"issue":"2","key":"2026090307191729000_cit2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"Ca-Cancer\nJ. Clin."},{"issue":"1","key":"2026090307191729000_cit3","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2017.00031","article-title":"Current and Future\nTreatment of Hepatocellular Carcinoma: An Updated Comprehensive Review","volume":"6","author":"Daher","year":"2018","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"1","key":"2026090307191729000_cit4","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i1.101","article-title":"Role of\nradiotherapy in the management of hepatocellular carcinoma: A systematic\nreview","volume":"7","author":"Kalogeridi","year":"2015","journal-title":"World J. Hepatol."},{"issue":"23","key":"2026090307191729000_cit5","doi-asserted-by":"publisher","DOI":"10.3390\/polym14235249","article-title":"Recent Advances in Stimuli-Responsive\nDoxorubicin Delivery Systems for Liver Cancer Therapy","volume":"14","author":"Radu","year":"2022","journal-title":"Polymers"},{"issue":"10","key":"2026090307191729000_cit6","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.1111\/cas.15068","article-title":"Reactive oxygen species\nin cancer: Current findings\nand future directions","volume":"112","author":"Nakamura","year":"2021","journal-title":"Cancer Sci."},{"issue":"5","key":"2026090307191729000_cit7","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9050374","article-title":"The Double-Faced\nRole of Nitric Oxide and Reactive Oxygen Species in Solid Tumors","volume":"9","author":"Mijatovic\u0301","year":"2020","journal-title":"Antioxidants"},{"key":"2026090307191729000_cit8","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.jiec.2020.11.026","article-title":"Nitric oxide and\nreactive oxygen species-releasing polylactic acid monolith for enhanced\nphotothermal therapy of osteosarcoma","volume":"94","author":"Lee","year":"2021","journal-title":"J. Ind.\nEng. Chem."},{"key":"2026090307191729000_cit9","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.jcis.2025.01.149","article-title":"Hypoxia-Targeted-Therapy:\nMussel-inspired hollow polydopamine nanocarrier containing MoS2 nanozyme\nand tirapazamine with anti-angiogenesis property for synergistic tumor\ntherapy","volume":"685","author":"Demissie","year":"2025","journal-title":"J. Colloid Interface Sci."},{"issue":"7","key":"2026090307191729000_cit10","doi-asserted-by":"publisher","first-page":"5650","DOI":"10.1021\/acsabm.1c00452","article-title":"Biomimetic Nanoreactor for Cancer\nEradication via Win\u2013Win Cooperation between Starvation\/Photo\/Chemodynamic\nTherapies","volume":"4","author":"Ciou","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"2026090307191729000_cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2026.103520","article-title":"Glutathione\/pH-responsive\ndisulfide-bridged\nsilica nanocarrier for synergistic chemo\/gas\/chemodynamic therapy","volume":"53","author":"Demissie","year":"2026","journal-title":"Mater. Today Chem."},{"issue":"1","key":"2026090307191729000_cit12","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-026-00419-2","article-title":"Reactive oxygen\nspecies in health and disease","volume":"7","author":"Ren","year":"2026","journal-title":"Mol. Biomed."},{"issue":"2","key":"2026090307191729000_cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.celld.2026.100009","article-title":"Reactive oxygen species\nin cell signaling and cell death: A redox perspective on metabolic\nand inflammatory disorders","volume":"2","author":"K","year":"2026","journal-title":"Cell Death"},{"issue":"18","key":"2026090307191729000_cit14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810574","article-title":"Reactive Nitrogen\nSpecies and Male Reproduction: Physiological and Pathological Aspects","volume":"23","author":"Dutta","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"2026090307191729000_cit15","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1021\/acsnano.9b05493","article-title":"Surface Charge\nSwitchable Supramolecular Nanocarriers for Nitric Oxide Synergistic\nPhotodynamic Eradication of Biofilms","volume":"14","author":"Hu","year":"2020","journal-title":"ACS Nano"},{"issue":"65","key":"2026090307191729000_cit16","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202201966","article-title":"Detection of Reactive\nOxygen and Nitrogen Species by Upconversion\nNanoparticle-Based Near-Infrared Nanoprobes: Recent Progress and Perspectives","volume":"28","author":"Yu","year":"2022","journal-title":"Chem. \u2013 Eur. 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Cell Biol."},{"issue":"23","key":"2026090307191729000_cit31","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26237198","article-title":"The Phosphorylated\nForm of the Histone H2AX (\u03b3H2AX) in the Brain from Embryonic\nLife to Old Age","volume":"26","author":"Merighi","year":"2021","journal-title":"Molecules"},{"issue":"4","key":"2026090307191729000_cit32","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/leu.2010.6","article-title":"\u03b3H2AX: a sensitive molecular\nmarker of DNA damage and repair","volume":"24","author":"Mah","year":"2010","journal-title":"Leukemia"},{"key":"2026090307191729000_cit33","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.actbio.2023.04.014","article-title":"A tumor-specific ROS\nself-supply enhanced cascade-responsive\nprodrug activation nanosystem for amplified chemotherapy against multidrug-resistant\ntumors","volume":"164","author":"Wang","year":"2023","journal-title":"Acta Biomater."},{"key":"2026090307191729000_cit34","doi-asserted-by":"publisher","DOI":"10.1093\/narcan\/zcae013","article-title":"XPA tumor variant leads to defects\nin NER that sensitize cells to cisplatin","volume":"6","author":"Blee","year":"2024","journal-title":"NAR\nCancer"},{"issue":"7959","key":"2026090307191729000_cit35","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41586-023-05959-z","article-title":"Lesion recognition\nby XPC, TFIIH and XPA in DNA excision repair","volume":"617","author":"Kim","year":"2023","journal-title":"Nature"},{"issue":"3","key":"2026090307191729000_cit36","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.bbrc.2019.05.050","article-title":"Structural\ncharacterization of the redefined DNA-binding domain of human XPA","volume":"514","author":"Lian","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c04069","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/34\/51215\/66914693\/acsomega.6c04069.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/34\/51215\/66914693\/acsomega.6c04069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:19:26Z","timestamp":1788434366000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/34\/51215\/5278608\/Synergistic-ROS-RNS-Mediated-Chemotherapy-via-M1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":36,"journal-issue":{"issue":"34","published-online":{"date-parts":[[2026,8,20]]},"published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c04069","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]}}}