{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:07:21Z","timestamp":1788876441456,"version":"build-2803163510"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["PVCET3179-2022"],"award-info":[{"award-number":["PVCET3179-2022"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["306335\/2023-9"],"award-info":[{"award-number":["306335\/2023-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["445615\/2024-9"],"award-info":[{"award-number":["445615\/2024-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["PVCET3179-2022"],"award-info":[{"award-number":["PVCET3179-2022"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda??o de Amparo ? i Pesquisa e ao Desenvolvimento Cient?fico e Tecnol?gico do Maranh?o","doi-asserted-by":"publisher","award":["PVCET3179-2022"],"award-info":[{"award-number":["PVCET3179-2022"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The search for sustainable and effective bioactive compounds from plant sources has intensified due to their potential applications in both healthcare and vector control. In this study, a thermoresponsive nanogel based on Pluronic F127 and Carbopol 974P was developed to incorporate the essential oil of Duguetia stelechantha (EODs; essential oil of D. stelechantha), aiming to improve its physicochemical stability and evaluate its biological activity in a nanostructured delivery system. The optimized formulation containing 1% (w\/w) EODs (nGDs) exhibited suitable physicochemical stability and pronounced thermoresponsive behavior, with a reversible sol\u2013gel transition occurring between 19 and 26 \u00b0C. Rheological analysis revealed increased viscosity and enhanced structural organization upon oil incorporation, while FTIR and DLS results confirmed the successful encapsulation of EODs and its influence on intermolecular interactions and nanostructural dynamics. Biological assays demonstrated that free EODs exhibited higher immediate leishmanicidal activity against Leishmania amazonensis promastigotes, whereas nGDs showed a time-dependent response, suggesting a possible modulation of essential oil availability within the nanogel matrix. Morphological analysis confirmed significant parasite damage following treatment. Additionally, nGDs exhibited strong larvicidal activity against Aedes aegypti, with LC50 and LC90 values of 97.7 \u00b1 6.4 and 177.7 \u00b1 18.3 \u03bcg\/mL, respectively. Overall, the developed thermoresponsive nanogel provides a stable platform for incorporating EODs and may contribute to modulating its biological response, although specific release and temperature-dependent biological assays are still required to confirm the functional role of the sol\u2013gel transition. This system represents a promising eco-friendly platform for dual antiparasitic therapy and vector control applications.<\/jats:p>","DOI":"10.1021\/acsomega.6c04271","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:36:39Z","timestamp":1788262599000},"page":"52796-52809","source":"Crossref","is-referenced-by-count":0,"title":["Thermoresponsive\nNanogel Incorporating\n                    <i>Duguetia stelechantha<\/i>\n                    Essential Oil: Biological Activity\nagainst\n                    <i>Leishmania<\/i>\n                    and\n                    <i>Aedes aegypti<\/i>\n                    Larvae"],"prefix":"10.1021","volume":"11","author":[{"given":"Raiene Lisboa","family":"Rocha","sequence":"first","affiliation":[{"name":"Federal University of Maranha\u0303o (UFMA) , , ,","place":["Sa\u0303o Lui\u0301s, Brazil, 65080-805"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0591-7817","authenticated-orcid":true,"given":"Arthur Girardi Francalin","family":"Laureano","sequence":"additional","affiliation":[{"name":"State University of Maringa\u0301 (DAB\/UEM) , , ,","place":["Maringa\u0301, Brazil, 87020-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thai\u0301ssa Gabrielle","family":"Corre\u0302a","sequence":"additional","affiliation":[{"name":"Federal University of Maranha\u0303o (UFMA) , , ,","place":["Sa\u0303o Lui\u0301s, Brazil, 65080-805"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Pires Souza","sequence":"additional","affiliation":[{"name":"Federal University of Amazonas (UFAM) , , ,","place":["Manaus, Brazil, 69080-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson Ferreira","family":"Sepulveda","sequence":"additional","affiliation":[{"name":"Federal University of Sa\u0303o Paulo (UNIFESP) , , , ,","place":["Sa\u0303o Paulo, SP, Brazil, 04021-001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agatha Maria","family":"Pelosine","sequence":"additional","affiliation":[{"name":"Federal University of Sa\u0303o Paulo (UNIFESP) , , , ,","place":["Sa\u0303o Paulo, SP, Brazil, 04021-001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-9742","authenticated-orcid":true,"given":"Clenilma","family":"Marques Branda\u0303o","sequence":"additional","affiliation":[{"name":"Federal Institute of Maranha\u0303o (IFMA) , , ,","place":["Sa\u0303o Lui\u0301s, Brazil, 65075-441"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Braga","sequence":"additional","affiliation":[{"name":"University College (COLUN), Federal University of Maranha\u0303o (UFMA) , ,","place":["Sa\u0303o Lui\u0301s, Brazil, 65080-805"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alexandre","family":"Holanda","sequence":"additional","affiliation":[{"name":"Federal University of Maranha\u0303o , , Bom Jesus Campus , , ,","place":["Imperatriz, MA, Brazil, 65915-060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Ste\u0301fanie Sara Lopes","family":"Lera-Nonose","sequence":"additional","affiliation":[{"name":"State University of Maringa\u0301 (DAB\/UEM) , , ,","place":["Maringa\u0301, Brazil, 87020-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Ribeiro","family":"de Araujo","sequence":"additional","affiliation":[{"name":"Federal University of Sa\u0303o Paulo (UNIFESP) , , , ,","place":["Sa\u0303o Paulo, SP, Brazil, 04021-001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanoel Vilac\u0327a","family":"Costa","sequence":"additional","affiliation":[{"name":"Federal University of Amazonas (UFAM) , , ,","place":["Manaus, Brazil, 69080-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Sonchini","family":"Gonc\u0327alves","sequence":"additional","affiliation":[{"name":"Federal University of Parana\u0301 (UFPR) , , , ,","place":["Palotina, PR, Brazil, 85950-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"2026090809111638500_cit1","unstructured":"World Health Organization.\n          . 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Pharmacother."},{"key":"2026090809111638500_cit4","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The Global Distribution\nand Burden of Dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"2026090809111638500_cit5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005625","article-title":"Contemporary\nStatus of Insecticide\nResistance in the Major Aedes Vectors of Arboviruses Infecting Humans","volume":"11","author":"Moyes","year":"2017","journal-title":"Nat. Commun."},{"key":"2026090809111638500_cit6","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1016\/S0140-6736(15)00417-1","article-title":"Averting a Malaria Disaster:\nWill Insecticide Resistance Derail Malaria\nControl?","volume":"387","author":"Hemingway","year":"2016","journal-title":"Lancet"},{"key":"2026090809111638500_cit7","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1590\/S0034-89102004000500002","article-title":"Suscetibilidade de larvas de Aedes\naegypti ao inseticida temefo\u0301s no Distrito Federal","volume":"38","author":"Carvalho","year":"2004","journal-title":"Rev. Saude Publica"},{"key":"2026090809111638500_cit8","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.1007\/s00436-015-4586-9","article-title":"Research in\nMosquito Control: Current Challenges for a Greener Future","volume":"114","author":"Benelli","year":"2015","journal-title":"Parasitol. Res."},{"key":"2026090809111638500_cit9","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1146\/annurev-ento-011019-025010","article-title":"Botanical\nInsecticides in the Twenty-First Century - Resolving Old Issues and\nBuilding New Prospects","volume":"65","author":"Isman","year":"2020","journal-title":"Annu. Rev. Entomol."},{"key":"2026090809111638500_cit10","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.fct.2007.09.106","article-title":"Biological Effects\nof Essential Oils \u2013 A Review","volume":"46","author":"Bakkali","year":"2008","journal-title":"Food Chem.\nToxicol."},{"key":"2026090809111638500_cit11","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ijfoodmicro.2004.03.022","article-title":"Essential\nOils: Their Antibacterial Properties and Potential Applications in\nFoods \u2013 A Review","volume":"94","author":"Burt","year":"2004","journal-title":"Int. J. Food Microbiol."},{"key":"2026090809111638500_cit12","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.3390\/ph6121451","article-title":"Effect of\nEssential Oils on Pathogenic Bacteria","volume":"6","author":"Nazzaro","year":"2013","journal-title":"Pharmaceuticals"},{"key":"2026090809111638500_cit13","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1159\/000092858","article-title":"Activity of the Essential\nOil from Chenopodium ambrosioides Grown\nin Cuba against Leishmania amazonensis","volume":"52","author":"Monzote","year":"2006","journal-title":"Chemotherapy"},{"key":"2026090809111638500_cit14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1590\/S0036-46652007000400012","article-title":"Combined Effect\nof the Essential Oil from Chenopodium ambrosioides and Antileishmanial\nDrugs on Promastigotes of Leishmania amazonensis","volume":"49","author":"Monzote","year":"2007","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"2026090809111638500_cit15","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.parint.2011.03.004","article-title":"In\nVitro Antileishmanial Activity and Cytotoxicity of Essential Oil from\nLippia sidoides Cham","volume":"60","author":"de Medeiros","year":"2011","journal-title":"Parasitol. Int."},{"key":"2026090809111638500_cit16","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0197-2018","article-title":"Different\nSusceptibilities of Aedes\naegypti and Aedes albopictus Larvae to Plant-Derived Products","volume":"52","author":"Rodrigues","year":"2019","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"2026090809111638500_cit17","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.indcrop.2018.02.072","article-title":"Beyond Mosquitoes: Essential Oils\nAgainst Arthropods","volume":"117","author":"Benelli","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"2026090809111638500_cit18","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jbiotec.2016.07.005","article-title":"Essential Oil Nanoemulsions\nas Antimicrobial Agents\nin Food","volume":"233","author":"Donsi","year":"2011","journal-title":"J. Biotechnol."},{"key":"2026090809111638500_cit19","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12050431","article-title":"Encapsulation\nof Essential Oils via Nanoprecipitation Process: Overview, Progress,\nChallenges and Prospects","volume":"12","author":"Lammari","year":"2020","journal-title":"Pharmaceutics"},{"key":"2026090809111638500_cit20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11095-006-9132-0","article-title":"Micellar\nNanocarriers: Pharmaceutical Perspectives","volume":"24","author":"Torchilin","year":"2007","journal-title":"Pharm.\nRes."},{"key":"2026090809111638500_cit21","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1126\/science.1095833","article-title":"Drug Delivery Systems:\nEntering the Mainstream","volume":"303","author":"Allen","year":"2004","journal-title":"Science"},{"key":"2026090809111638500_cit22","doi-asserted-by":"publisher","first-page":"311","DOI":"10.17516\/1997-1389-0305","article-title":"Nanotechnology-Based\nDelivery Systems: Highlights in Agricultural Applications","volume":"12","author":"de Oliveira","year":"2019","journal-title":"J. Sib. Fed. Univ. Biol."},{"key":"2026090809111638500_cit23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0939-6411(00)00090-4","article-title":"Hydrogels in Pharmaceutical\nFormulations","volume":"50","author":"Peppas","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"2026090809111638500_cit24","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1016\/j.polymer.2008.01.027","article-title":"Hydrogels in Drug\nDelivery: Progress and Challenges","volume":"49","author":"Hoare","year":"2008","journal-title":"Polymer"},{"key":"2026090809111638500_cit25","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.progpolymsci.2008.01.002","article-title":"The Development\nof Microgels\/Nanogels for Drug Delivery Applications","volume":"33","author":"Oh","year":"2008","journal-title":"Prog. Polym. Sci."},{"key":"2026090809111638500_cit26","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/jbm.820060609","article-title":"Artificial\nSkin I: Preparation and Properties of Pluronic F-127 Gels for Treatment\nof Burns","volume":"6","author":"Schmolka","year":"1972","journal-title":"J. Biomed. Mater. Res."},{"key":"2026090809111638500_cit27","doi-asserted-by":"crossref","unstructured":"Kabanov, A. V.; Alakhov, V. Y.\n          Pluronic Block\nCopolymers in Drug Delivery: From Micellar Nanocontainers to Biological\nResponse Modifiers\n          Crit. Rev. Ther. Drug Carrier\nSyst.\n          2002; Vol. 19.","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v19.i1.10"},{"key":"2026090809111638500_cit28","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.addr.2012.09.024","article-title":"Environment-Sensitive Hydrogels for Drug Delivery","volume":"64","author":"Qiu","year":"2012","journal-title":"Adv. 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Crops Prod."},{"key":"2026090809111638500_cit32","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jbiotec.2016.07.005","article-title":"Essential oil nanoemulsions\nas antimicrobial agents\nin food","volume":"233","author":"Donsi","year":"2016","journal-title":"J. Biotechnol."},{"key":"2026090809111638500_cit33","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24142539","article-title":"Encapsulation of Essential Oils for\nthe Development of Biosourced Pesticides with Controlled Release:\nA Review","volume":"24","author":"Maes","year":"2019","journal-title":"Molecules"},{"key":"2026090809111638500_cit34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11095-006-9132-0","article-title":"Micellar\nnanocarriers: pharmaceutical perspectives","volume":"24","author":"Torchilin","year":"2006","journal-title":"Pharm.\nRes."},{"key":"2026090809111638500_cit35","volume-title":"Identification of\nEssential Oil Components by Gas Chromatography\/Mass Spectrometry","author":"Adams","year":"2007","edition":"4"},{"key":"2026090809111638500_cit36","doi-asserted-by":"publisher","DOI":"10.3390\/polym17030379","article-title":"Nanotechnological\nFormulation Incorporating Pectis brevipedunculata (Asteraceae) Essential\nOil: An Ecofriendly Approach for Leishmanicidal and Anti-Inflammatory\nTherapy","volume":"17","author":"Marques","year":"2025","journal-title":"Polymers"},{"key":"2026090809111638500_cit37","unstructured":"Age\u0302ncia Nacional de Vigila\u0302ncia Sanita\u0301ria (ANVISA).\n          . 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Visualized\nExp."},{"key":"2026090809111638500_cit43","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/mrc.1270070907","article-title":"13C-NMR-Spektren von Monoterpenen","volume":"7","author":"Bohlmann","year":"1975","journal-title":"Org. Magn. Reson."},{"key":"2026090809111638500_cit44","doi-asserted-by":"publisher","first-page":"725","DOI":"10.4014\/jmb.2310.10018","article-title":"Production\nof Mono-Hydroxylated Derivatives of Terpinen-4-ol by Bacterial CYP102A1\nEnzymes","volume":"33","author":"Kim","year":"2023","journal-title":"J. Microbiol. Biotechnol."},{"key":"2026090809111638500_cit45","doi-asserted-by":"publisher","DOI":"10.1093\/jisesa\/iev071","article-title":"Contact Toxicity and Repellency of the Main Components\nFrom the Essential Oil of Clausena anisum-olens Against Two Stored\nProduct Insects","volume":"15","author":"You","year":"2015","journal-title":"J. Insect Sci."},{"key":"2026090809111638500_cit46","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.720816","article-title":"Insecticidal Terpenes From the Essential Oils of Artemisia nakaii\nand Their Inhibitory Effects on Acetylcholinesterase","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Plant Sci."},{"key":"2026090809111638500_cit47","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1248\/cpb.42.138","article-title":"Constituents\nof Sindora sumatrana MIQ. I. Isolation and NMR Spectral Analysis of\nSesquiterpenes from the Dried Pods","volume":"42","author":"Heymann","year":"1994","journal-title":"Chem. Pharm.\nBull."},{"key":"2026090809111638500_cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11290-x","article-title":"Orthogonal\nmonoterpenoid biosynthesis in yeast constructed\non an isomeric substrate","volume":"10","author":"Ignea","year":"2019","journal-title":"Nat. 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