{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:25:12Z","timestamp":1786465512294,"version":"build-2736575974"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/05155-8"],"award-info":[{"award-number":["2015\/05155-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","award":["2025TR1577"],"award-info":[{"award-number":["2025TR1577"]}],"id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Salicylic acid is widely used in pharmaceutical and cosmetic applications, where reliable solubility data are critical for optimizing crystallization-based purification processes. While literature reports values for neat solvents, comprehensive measurements in binary water\u2013alcohol mixtures over the full composition range remain scarce. In this work, the mole fraction solubility of salicylic acid was experimentally determined in the binary mixtures of water + methanol, water + ethanol, and water +2-propanol over the entire solvent composition range at temperatures from 283.2 to 323.2 K at atmospheric pressure using a gravimetric method. The experimental data were analyzed using analytical solutions of groups (ASOG), PC-SAFT, and PSRK thermodynamic models to describe the solid\u2013liquid equilibrium behavior. PC-SAFT showed the best overall performance, yielding the lowest deviations, followed by PSRK and ASOG. The solubility increases monotonically with temperature in all systems, indicating an endothermic dissolution process. In mixed solvents, the solubility decreases sharply with an increasing water mole fraction, supporting the antisolvent effect of water. This behavior is associated with solvent polarity and specific solute\u2013solvent interactions. Alcohols act as effective cosolvents, increasing solubility as the solvent polarity decreases. The new data sets fill important gaps in the literature and provide a consistent basis for thermodynamic modeling, supporting the improved design of crystallization and separation processes involving salicylic acid.<\/jats:p>","DOI":"10.1021\/acsomega.6c04286","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:06:55Z","timestamp":1785128815000},"page":"46583-46594","source":"Crossref","is-referenced-by-count":0,"title":["Solubility Behavior\nof Salicylic Acid in Aqueous Alcohol\nMixtures: Interplay of Temperature, Solvent Composition, and Thermodynamic\nModeling"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8255-4511","authenticated-orcid":true,"given":"Alessandro C.","family":"Galva\u0303o","sequence":"first","affiliation":[{"name":"Santa Catarina State University\u2500UDESC , , , ,","place":["Pinhalzinho, Santa Catarina, Brazil, 89870-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme A.","family":"Mariane","sequence":"additional","affiliation":[{"name":"Santa Catarina State University\u2500UDESC , , , ,","place":["Pinhalzinho, Santa Catarina, Brazil, 89870-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Bordignon","sequence":"additional","affiliation":[{"name":"Santa Catarina State University\u2500UDESC , , , ,","place":["Pinhalzinho, Santa Catarina, Brazil, 89870-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor G.","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Santa Catarina State University\u2500UDESC , , , ,","place":["Pinhalzinho, Santa Catarina, Brazil, 89870-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4687-5297","authenticated-orcid":true,"given":"Pedro F.","family":"Arce","sequence":"additional","affiliation":[{"name":"University of Sa\u0303o Paulo\u2500USP , , , ,","place":["Lorena, Sa\u0303o Paulo, Brazil, 12602-810"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weber S.","family":"Robazza","sequence":"additional","affiliation":[{"name":"Santa Catarina State University\u2500UDESC , , , ,","place":["Pinhalzinho, Santa Catarina, Brazil, 89870-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"issue":"1","key":"2026081110191805500_cit1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s11094-024-03115-z","article-title":"Pharmacological\nProperties of Acetylsalicylic\nAcid and Its Complex with Glycyrrhizic Acid as a Promising Dosage\nForm","volume":"58","author":"Khisamutdinova","year":"2024","journal-title":"Pharm. Chem. J."},{"key":"2026081110191805500_cit2","doi-asserted-by":"publisher","first-page":"455","DOI":"10.2147\/CCID.S84765","article-title":"Salicylic\nAcid as a Peeling Agent: A Comprehensive Review","volume":"8","author":"Arif","year":"2015","journal-title":"Clin., Cosmet. Invest. Dermatol."},{"issue":"1","key":"2026081110191805500_cit3","doi-asserted-by":"publisher","first-page":"S428","DOI":"10.1016\/j.fct.2007.09.053","article-title":"Fragrance Material Review on Methyl Salicylate","volume":"45","author":"Lapczynski","year":"2007","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"2026081110191805500_cit4","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1021\/je7004962","article-title":"Solubility of Salicylic Acid in Water,\nEthanol, Carbon\nTetrachloride, Ethyl Acetate, and Xylene","volume":"53","author":"Shalmashi","year":"2008","journal-title":"J.\nChem. Eng. 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Thermophys."},{"issue":"10","key":"2026081110191805500_cit14","doi-asserted-by":"publisher","first-page":"4855","DOI":"10.1021\/acs.jced.0c00443","article-title":"Solubility of Salicylic Acid, Salicylamide,\nand Fenofibrate\nin Organic Solvents at Low Temperatures","volume":"65","author":"Sadeghi","year":"2020","journal-title":"J.\nChem. Eng. Data"},{"key":"2026081110191805500_cit15","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jct.2012.09.006","article-title":"Solubility\nof Salicylic Acid in Pure Alcohols at Different Temperatures","volume":"57","author":"Lim","year":"2013","journal-title":"J. Chem. Thermodyn."},{"issue":"3","key":"2026081110191805500_cit16","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/jps.21497","article-title":"Thermodynamics of Cosolvent Action:\nPhenacetin, Salicylic\nAcid and Probenecid","volume":"98","author":"Pen\u0303a","year":"2009","journal-title":"J. Pharm. Sci."},{"issue":"6","key":"2026081110191805500_cit17","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1021\/je990134w","article-title":"Solubility\nof 2-Hydroxybenzoic Acid in Select Organic Solvents at 298.15 K","volume":"44","author":"De Fina","year":"1999","journal-title":"J. Chem. Eng. Data"},{"issue":"11","key":"2026081110191805500_cit18","doi-asserted-by":"publisher","first-page":"3303","DOI":"10.1021\/je300980k","article-title":"Solubility\nof 2-Hydroxybenzoic Acid in Water, 1-Propanol, 2-Propanol, and 2-Propanone\nat (298.2 to 338.2) K and Their Aqueous Binary Mixtures at 298.2 K","volume":"57","author":"Fakhree","year":"2012","journal-title":"J. Chem. Eng. 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Sci."},{"key":"2026081110191805500_cit25","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.molliq.2017.09.060","article-title":"Experimental\nStudy and Thermodynamic Modeling of Xylitol and Sorbitol Solubility\nin Mixtures of Methanol and Ethanol at Different Temperatures","volume":"248","author":"Galva\u0303o","year":"2017","journal-title":"J. Mol. Liq."},{"key":"2026081110191805500_cit26","doi-asserted-by":"publisher","first-page":"114358","DOI":"10.1016\/j.fluid.2025.114358","article-title":"Solubility of Xylitol\nin Mixtures of Water and Methanol\nor Ethanol: Experimental Measurements and Thermodynamic Modeling","volume":"594","author":"Galva\u0303o","year":"2025","journal-title":"Fluid Phase Equilib."},{"key":"2026081110191805500_cit27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0040-6031(02)00091-6","article-title":"Calculation of Vapor Pressure Curves\nfor Hydroxy Benzoic Acid Derivatives Using Thermogravimetry","volume":"392\u2013393","author":"Chatterjee","year":"2002","journal-title":"Thermochim. 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Jpn."},{"issue":"4","key":"2026081110191805500_cit31","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1021\/ie0003887","article-title":"Perturbed-Chain SAFT:\nAn Equation of State Based on\na Perturbation Theory for Chain Molecules","volume":"40","author":"Gross","year":"2001","journal-title":"Ind.\nEng. Chem. Res."},{"issue":"22","key":"2026081110191805500_cit32","doi-asserted-by":"publisher","first-page":"5510","DOI":"10.1021\/ie010954d","article-title":"Application of the Perturbed-Chain SAFT Equation of\nState to Associating Systems","volume":"41","author":"Gross","year":"2002","journal-title":"Ind. Eng. Chem.\nRes."},{"issue":"8","key":"2026081110191805500_cit33","doi-asserted-by":"publisher","first-page":"2917","DOI":"10.1021\/ie970781l","article-title":"Using Molecular\nOrbital Calculations to Describe the\nPhase Behavior of Cross-Associating Mixtures","volume":"37","author":"Wolbach","year":"1998","journal-title":"Ind. Eng. Chem. 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