{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:02:28Z","timestamp":1785250948432,"version":"3.55.0"},"reference-count":26,"publisher":"American Chemical Society (ACS)","issue":"29","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20232BAB216135"],"award-info":[{"award-number":["20232BAB216135"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20242BAB21036"],"award-info":[{"award-number":["20242BAB21036"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ortho-C\u2013H alkenylation of aromatic ketones is a key transformation for bioactive molecules and functional materials, but all existing methods rely on scarce noble metals, hindering industrial applications. Herein, we report the first manganese-catalyzed ortho-C\u2013H alkenylation of aromatic ketones with commercial acrylates. Using MnBr(CO)5 as the precatalyst, the reaction proceeds under mild aqueous conditions with broad substrate scope, scalable to 10 mmol, and allows tunable mono\/bis-alkenylation via acrylate stoichiometry. Mechanistic studies support an electrophilic C\u2013H metalation pathway, and the products can be readily derivatized to isoquinoline frameworks. This work provides a sustainable alternative and enables manganese catalysis with weakly coordinating directing groups.<\/jats:p>","DOI":"10.1021\/acsomega.6c04363","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:55:57Z","timestamp":1784127357000},"page":"44318-44325","source":"Crossref","is-referenced-by-count":0,"title":["Manganese-Catalyzed\n                    <i>Ortho<\/i>\n                    -C\u2013H\nAlkenylation of Aromatic Ketones"],"prefix":"10.1021","volume":"11","author":[{"given":"Xue","family":"Wang","sequence":"first","affiliation":[{"name":"Ganzhou Polytechnic College , , , ,","place":["Ganzhou, Jiangxi Province, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Huang","sequence":"additional","affiliation":[{"name":"Gannan Medical University , , ,","place":["Ganzhou, Jiangxi Province, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Gannan Medical University , , ,","place":["Ganzhou, Jiangxi Province, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehong","family":"Zou","sequence":"additional","affiliation":[{"name":"Ganzhou Polytechnic College , , , ,","place":["Ganzhou, Jiangxi Province, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Nie","sequence":"additional","affiliation":[{"name":"Ganzhou Polytechnic College , , , ,","place":["Ganzhou, Jiangxi Province, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-5491","authenticated-orcid":true,"given":"Jinquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gannan Medical University , , ,","place":["Ganzhou, Jiangxi Province, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Chen","sequence":"additional","affiliation":[{"name":"Ganzhou People\u2019s Hospital , , ,","place":["Ganzhou, Jiangxi Province, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7951-9233","authenticated-orcid":true,"given":"Ziyan","family":"Meng","sequence":"additional","affiliation":[{"name":"Ganzhou Polytechnic College , , , ,","place":["Ganzhou, Jiangxi Province, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2026072810093796900_cit1","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1126\/science.1169975","article-title":"Palladium-Catalyzed C7-Selective C-H Arylation of Pyrazolo[1,5-a]pyrimidines","volume":"323","author":"Phipps","year":"2009","journal-title":"Science"},{"key":"2026072810093796900_cit2","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1002\/anie.200500468","article-title":"Palladium-Catalyzed\nIntermolecular Alkenylation of Indoles by Solvent-Controlled Regioselective\nC-H Functionalization","volume":"44","author":"Grimster","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026072810093796900_cit3","first-page":"8787","article-title":"Ligand-Controlled\nRegiodivergent\nC-H Arylation of Pyrazolo[1,5-a]pyrimidines","volume":"54","author":"Phipps","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026072810093796900_cit4","doi-asserted-by":"publisher","first-page":"6144","DOI":"10.1021\/ol202580e","article-title":"Ruthenium-Catalyzed Ortho-Alkenylation of Aromatic\nKetones with Alkenes by C-H Bond Activation","volume":"13","author":"Padala","year":"2011","journal-title":"Org. Lett."},{"key":"2026072810093796900_cit5","doi-asserted-by":"publisher","first-page":"20218","DOI":"10.1021\/ja205294y","article-title":"Theoretical\nAnalysis of the Mechanism of Palladium(II)\nAcetate-Catalyzed Oxidative Heck Coupling of Electron-Deficient Arenes\nwith Alkenes: Effects of the Pyridine-Type Ancillary Ligand and Origins\nof the meta-Regioselectivity","volume":"133","author":"Zhang","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"2026072810093796900_cit6","doi-asserted-by":"publisher","first-page":"151471","DOI":"10.1016\/j.tetlet.2019.151471","article-title":"Controlling\nReactivity in the Fujiwara\u2013Moritani Reaction: Examining Solvent\nEffects and the Addition of 1,3-Dicarbonyl Ligands on the Oxidative\nCoupling of Electron Rich Arenes and Acrylates","volume":"61","author":"Jones","year":"2020","journal-title":"Tetrahedron Lett."},{"key":"2026072810093796900_cit7","doi-asserted-by":"publisher","first-page":"8709","DOI":"10.1021\/acscatal.8b02639","article-title":"Iridium-Catalyzed\nOxidative Heteroarylation of Arenes\nand Alkenes: Overcoming the Restriction to Specific Substrates","volume":"8","author":"Tan","year":"2018","journal-title":"ACS Catal."},{"key":"2026072810093796900_cit8","doi-asserted-by":"publisher","first-page":"5496","DOI":"10.1021\/acs.orglett.6b02698","article-title":"Electronic Nature of Ketone Directing\nGroup as a Key To Control C-2 vs C-4 Alkenylation of Indoles","volume":"18","author":"Lanke","year":"2016","journal-title":"Org. 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Soc."},{"key":"2026072810093796900_cit12","first-page":"9876","article-title":"Recent Advances\nin Transition-Metal-Catalyzed\nC-H Functionalization","volume":"120","author":"Chen","year":"2020","journal-title":"Chem. Rev."},{"key":"2026072810093796900_cit13","doi-asserted-by":"publisher","first-page":"4495","DOI":"10.1021\/acs.orglett.8b01770","article-title":"Manganese-Catalyzed\northo-C\u2013H Amidation of Weakly Coordinating\nAromatic Ketones","volume":"20","author":"Kong","year":"2018","journal-title":"Org. Lett."},{"key":"2026072810093796900_cit14","doi-asserted-by":"publisher","first-page":"6961","DOI":"10.1021\/acs.orglett.9b02554","article-title":"Manganese-Catalyzed Aromatic C\u2013H\nAllylation\nof Ketones","volume":"21","author":"Ali","year":"2019","journal-title":"Org. 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Chem."},{"key":"2026072810093796900_cit21","first-page":"567","article-title":"Stereoselective\nC-H Functionalization\nfor the Synthesis of Complex Molecules","volume":"14","author":"Brown","year":"2022","journal-title":"Nat.\nChem."},{"key":"2026072810093796900_cit22","first-page":"12345","article-title":"Electrochemical\nC-H Activation: A\nSustainable Approach to Organic Synthesis","volume":"13","author":"Yang","year":"2023","journal-title":"ACS\nCatal."},{"key":"2026072810093796900_cit23","first-page":"3456","article-title":"Photoredox-Catalyzed\nC-H Functionalization","volume":"49","author":"Liu","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"2026072810093796900_cit24","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1021\/acs.chemrev.8b00507","article-title":"3d Transition\nMetals for C-H Activation","volume":"119","author":"Gandeepan","year":"2019","journal-title":"Chem. 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