{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:06:50Z","timestamp":1788876410407,"version":"build-2803163510"},"reference-count":96,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The current trend in antiepileptic drug (AED) development entails finding and creating safer, more effective technologies as the world continues to source AEDs, thereby creating a larger carbon footprint through the batch-process method of manufacturing AEDs, along with potential resource limitations and\/or supply chain constraints on batch-manufactured products. This review will evaluate the change in AED manufacturing from the batch-process method to the continuous-flow process and the advantages associated with integrating environmentally friendly chemical methods into continuous-flow manufacturing processes to create AEDs and the new generation of AEDs with reduced waste. The review will examine examples of recent advances in continuous-flow processing of major molecules, including pregabalin, levetiracetam, lacosamide, and brivaracetam. In addition, the review will discuss the obstacles preventing a complete transition to an automated, environmentally friendly, and continuous-flow process for producing AEDs.<\/jats:p>","DOI":"10.1021\/acsomega.6c04439","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:26:13Z","timestamp":1788215173000},"page":"52312-52331","source":"Crossref","is-referenced-by-count":0,"title":["Continuous-Flow\nSynthesis of Antiepileptic Drugs:\nProcess Intensification, Sustainability Metrics, and Scalable Manufacturing"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5800-3587","authenticated-orcid":true,"given":"Amit","family":"Upadhyay","sequence":"first","affiliation":[{"name":"Mahayogi Gorakhnath University Gorakhpur , , Arogya Dham, Sonbarsa , , ,","place":["Gorakhpur, Uttar Pradesh, India, 273007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3771-6227","authenticated-orcid":true,"given":"Alka","family":"Raj Pandey","sequence":"additional","affiliation":[{"name":"Lloyd Institute of Management & Technology , Plot No. 11, Knowledge Park-II , , ,","place":["Greater Noida, Uttar Pradesh, India, 201306"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini","family":"Mishra","sequence":"additional","affiliation":[{"name":"University College Dublin , , Belfield, ,","place":["Dublin, Ireland, D04 V1W8"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-3926","authenticated-orcid":true,"given":"Shashank","family":"Tewari","sequence":"additional","affiliation":[{"name":"Manipal Academy of Higher Education , , , ,","place":["Manipal, Karnataka, India, 576104"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"issue":"3","key":"2026090809085546800_cit1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.70044","article-title":"Dynamics of Neuronal and Astrocytic Energy Molecules in Epilepsy","volume":"169","author":"Furukawa","year":"2025","journal-title":"J. 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