{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:10:36Z","timestamp":1790093436956,"version":"4.0.1"},"reference-count":97,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016107","name":"Science and Technology Department of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["XZ202401JD0012"],"award-info":[{"award-number":["XZ202401JD0012"]}],"id":[{"id":"10.13039\/501100016107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1801000"],"award-info":[{"award-number":["2023YFD1801000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011501","name":"Qinghai Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2023-NK-135"],"award-info":[{"award-number":["2023-NK-135"]}],"id":[{"id":"10.13039\/501100011501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ24C180001"],"award-info":[{"award-number":["LZ24C180001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Zika virus (ZIKV), a mosquito-borne flavivirus, has emerged as a public health concern. Although asymptomatic or mild febrile illness in adults, ZIKV infection can lead to severe outcomes in pregnant women, including fetal microcephaly and congenital Zika syndrome. A hallmark of ZIKV pathogenesis is the virus-induced remodeling of the endoplasmic reticulum into specialized replication organelles (ROs), which function as spatially organized hubs that actively couple viral RNA synthesis with the host translation machinery. These specialized ROs enhance viral genome amplification, prioritizes viral mRNA translation, and minimizes the cytosolic exposure of immunostimulatory viral double-stranded RNA intermediates. This review explores how this spatial coupling underlies the unique tropism of ZIKV towards neural progenitor cells, a characteristic that sets it apart from other neurotropic flaviviruses. In particular, ZIKV adaptations that simultaneously promote viral replication and disrupt host neurogenesis are critically discussed.<\/jats:p>","DOI":"10.1021\/acsomega.6c04495","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:02:06Z","timestamp":1788890526000},"page":"54793-54803","source":"Crossref","is-referenced-by-count":0,"title":["Spatial Coupling\nof Viral RNA Translation and Replication\nin Zika Infection"],"prefix":"10.1021","volume":"11","author":[{"given":"Guanghui","family":"Zheng","sequence":"first","affiliation":[{"name":"Qinghai University , , , ,","place":["Xining, Qinghai Province, China, 810016"]},{"name":"College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University , , ,","place":["Hangzhou, China, 311300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University , , ,","place":["Hangzhou, China, 311300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedong","family":"He","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University , , ,","place":["Hangzhou, China, 311300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Tao","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital , ,","place":["Lanzhou, China, 730030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ministry of Science and Technology , , ,","place":["Shanghai, China, 200025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luping","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University , , ,","place":["Hangzhou, China, 311300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mianmian","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University , , ,","place":["Hangzhou, China, 311300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4975-4615","authenticated-orcid":true,"given":"Pengfei","family":"Cai","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute , , , ,","place":["Brisbane, Queensland, Australia, 4006"]},{"name":"The University of Queensland , , ,","place":["Brisbane, Australia, 4072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-4586","authenticated-orcid":true,"given":"William C.","family":"Cho","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital , , Kowloon, SAR,","place":["Hong Kong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-9978","authenticated-orcid":true,"given":"Yadong","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University , , ,","place":["Hangzhou, China, 311300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Qinghai University , , , ,","place":["Xining, Qinghai Province, China, 810016"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"30","key":"2026092210583809100_cit1","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.46234\/ccdcw2025.169","article-title":"The First Imported\nCase of Zika Virus Infection - Shandong Province, China, 2025","volume":"7","author":"Shu","year":"2025","journal-title":"China CDC Wkly."},{"key":"2026092210583809100_cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.702048","article-title":"Inhibition of Tryptophan Catabolism Is Associated With\nNeuroprotection During Zika Virus Infection","volume":"12","author":"Marim","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"2026092210583809100_cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56669-4","article-title":"Low vector\ncompetence in sylvatic mosquitoes limits Zika virus to initiate an\nenzootic cycle in South America","volume":"9","author":"Fernandes","year":"2019","journal-title":"Sci. Rep."},{"issue":"6","key":"2026092210583809100_cit4","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12061177","article-title":"Predicting Efficacy\nof a Purified Inactivated Zika\nVirus Vaccine in Flavivirus-Nai\u0308ve Humans Using an Immunological\nCorrelate of Protection in Non-Human Primates","volume":"12","author":"Acosta","year":"2024","journal-title":"Microorganisms"},{"key":"2026092210583809100_cit5","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.virol.2020.01.015","article-title":"Zika virus-spread,\nepidemiology, genome, transmission cycle, clinical manifestation,\nassociated challenges, vaccine and antiviral drug development","volume":"543","author":"Pielnaa","year":"2020","journal-title":"Virology"},{"issue":"1","key":"2026092210583809100_cit6","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-016-0623-2","article-title":"Zika Virus on a Spreading Spree:\nwhat we now know that\nwas unknown in the 1950\u2019s","volume":"13","author":"Basu","year":"2016","journal-title":"Virol. J."},{"issue":"6365","key":"2026092210583809100_cit7","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1126\/science.aam7120","article-title":"A single\nmutation in the prM protein of Zika virus\ncontributes to fetal microcephaly","volume":"358","author":"Yuan","year":"2017","journal-title":"Science"},{"issue":"7","key":"2026092210583809100_cit8","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1056\/NEJMp1600297","article-title":"Zika Virus in the Americas--Yet Another Arbovirus Threat","volume":"374","author":"Fauci","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2026092210583809100_cit9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.meegid.2019.01.018","article-title":"ZIKA\nvirus entry mechanisms in human cells","volume":"69","author":"Agrelli","year":"2019","journal-title":"Infect.\nGenet. Evol."},{"issue":"1","key":"2026092210583809100_cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43665-6","article-title":"Zika virus remodelled ER membranes contain proviral\nfactors involved in redox and methylation pathways","volume":"14","author":"Denolly","year":"2023","journal-title":"Nat. Commun."},{"issue":"5","key":"2026092210583809100_cit11","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02375-19","article-title":"Zika Virus NS2A-Mediated Virion Assembly","volume":"10","author":"Zhang","year":"2019","journal-title":"mBio"},{"issue":"10","key":"2026092210583809100_cit12","doi-asserted-by":"publisher","first-page":"4731","DOI":"10.1128\/JVI.00002-08","article-title":"Role of nonstructural protein NS2A in flavivirus assembly","volume":"82","author":"Leung","year":"2008","journal-title":"J. Virol."},{"issue":"8","key":"2026092210583809100_cit13","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12740","article-title":"Zika virus induced\ncellular remodelling","volume":"19","author":"Rossignol","year":"2017","journal-title":"Cell. Microbiol."},{"issue":"9","key":"2026092210583809100_cit14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010329","article-title":"Arbovirus-vector\nprotein interactomics identifies Loquacious as a co-factor for dengue\nvirus replication in Aedes mosquitoes","volume":"18","author":"Besson","year":"2022","journal-title":"PLoS\nPathog."},{"issue":"9","key":"2026092210583809100_cit15","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70605","article-title":"A Pyrido-Quinoxaline Derivative That Downregulates\nReticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika\nVirus","volume":"97","author":"Plicanti","year":"2025","journal-title":"J. Med. Virol."},{"issue":"4","key":"2026092210583809100_cit16","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.chom.2009.03.007","article-title":"Composition and three-dimensional architecture of the\ndengue virus replication and assembly sites","volume":"5","author":"Welsch","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"1","key":"2026092210583809100_cit17","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev-virology-100114-055007","article-title":"Flaviviridae Replication Organelles:\nOh, What a Tangled\nWeb We Weave","volume":"2","author":"Paul","year":"2015","journal-title":"Annu. Rev. Virol."},{"issue":"7","key":"2026092210583809100_cit18","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.3390\/v6072826","article-title":"Membranous\nreplication factories induced by plus-strand\nRNA viruses","volume":"6","author":"Romero-Brey","year":"2014","journal-title":"Viruses"},{"issue":"6","key":"2026092210583809100_cit19","doi-asserted-by":"publisher","DOI":"10.3390\/v13060956","article-title":"Molecular Insights\ninto the Flavivirus Replication Complex","volume":"13","author":"van den Elsen","year":"2021","journal-title":"Viruses"},{"issue":"9","key":"2026092210583809100_cit20","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1016\/j.celrep.2017.02.014","article-title":"Ultrastructural\nCharacterization of Zika Virus Replication\nFactories","volume":"18","author":"Cortese","year":"2017","journal-title":"Cell Rep."},{"issue":"3","key":"2026092210583809100_cit21","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nrmicro.2017.170","article-title":"Rewiring cellular\nnetworks by members of the Flaviviridae family","volume":"16","author":"Neufeldt","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"2026092210583809100_cit22","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-020-0618-6","article-title":"Endoplasmic reticulum:\na focal point of Zika virus infection","volume":"27","author":"Ropidi","year":"2020","journal-title":"J. Biomed.\nSci."},{"key":"2026092210583809100_cit23","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1201640","article-title":"Validation\nof flavivirus\ninfectious clones carrying fluorescent markers for antiviral drug\nscreening and replication studies","volume":"14","author":"Cherkashchenko","year":"2023","journal-title":"Front. Microbiol."},{"issue":"3","key":"2026092210583809100_cit24","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02113-24","article-title":"The Japanese encephalitis\nvirus NS1 protein concentrates ER membranes\nin a cytoskeleton-independent manner to facilitate viral replication","volume":"99","author":"Xie","year":"2025","journal-title":"J. Virol."},{"issue":"4","key":"2026092210583809100_cit25","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1128\/JVI.01249-13","article-title":"Cellular vimentin regulates construction of dengue\nvirus replication complexes through interaction with NS4A protein","volume":"88","author":"Teo","year":"2014","journal-title":"J. Virol."},{"issue":"36","key":"2026092210583809100_cit26","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305093","article-title":"Flavivirus\nConcentrates Host ER in Main Replication Compartments\nto Facilitate Replication","volume":"10","author":"Ci","year":"2023","journal-title":"Adv. Sci."},{"key":"2026092210583809100_cit27","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.94347.3","article-title":"Zika\nvirus remodels and hijacks IGF2BP2 ribonucleoprotein\ncomplex to promote viral replication organelle biogenesis","volume":"13","author":"Mazeaud","year":"2024","journal-title":"eLife"},{"issue":"2","key":"2026092210583809100_cit28","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70194","article-title":"Dengue Virus\nReplicative-Form dsRNA Is Recognized by Both RIG-I and MDA5 to Activate\nInnate Immunity","volume":"97","author":"Ye","year":"2025","journal-title":"J. Med. Virol."},{"issue":"3","key":"2026092210583809100_cit29","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8030148","article-title":"Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication\nand Assembly Complexes","volume":"8","author":"Rothan","year":"2019","journal-title":"Pathogens"},{"key":"2026092210583809100_cit30","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.coviro.2014.09.020","article-title":"Coupling\nof replication and assembly\nin flaviviruses","volume":"9","author":"Apte-Sengupta","year":"2014","journal-title":"Curr. Opin. Virol."},{"issue":"11","key":"2026092210583809100_cit31","doi-asserted-by":"publisher","first-page":"4939","DOI":"10.1007\/s00018-021-03834-6","article-title":"Compartmentalized replication\norganelle of flavivirus at the ER and\nthe factors involved","volume":"78","author":"Ci","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"issue":"24","key":"2026092210583809100_cit32","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00596-21","article-title":"Genome-Wide CRISPR Screen Identifies\nRACK1 as a Critical Host Factor for Flavivirus Replication","volume":"95","author":"Shue","year":"2021","journal-title":"J. Virol."},{"issue":"9","key":"2026092210583809100_cit33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004978","article-title":"Nonstructural Proteins\nAre Preferential Positive Selection Targets in Zika Virus and Related\nFlaviviruses","volume":"10","author":"Sironi","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"20","key":"2026092210583809100_cit34","doi-asserted-by":"publisher","first-page":"10438","DOI":"10.1128\/JVI.00986-10","article-title":"The Endoplasmic\nReticulum Provides the Membrane Platform for Biogenesis of the Flavivirus\nReplication Complex","volume":"84","author":"Gillespie","year":"2010","journal-title":"J. Virol."},{"issue":"6346","key":"2026092210583809100_cit35","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1126\/science.aam9243","article-title":"Neurodevelopmental\nprotein Musashi-1 interacts\nwith the Zika genome and promotes viral replication","volume":"357","author":"Chavali","year":"2017","journal-title":"Science"},{"issue":"6","key":"2026092210583809100_cit36","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41579-018-0003-6","article-title":"Autophagy\nduring viral infection\n- a double-edged sword","volume":"16","author":"Choi","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"issue":"4","key":"2026092210583809100_cit37","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.chom.2007.09.003","article-title":"Cholesterol manipulation by West\nNile virus perturbs the cellular immune response","volume":"2","author":"Mackenzie","year":"2007","journal-title":"Cell Host Microbe"},{"issue":"9","key":"2026092210583809100_cit38","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1128\/JVI.00118-14","article-title":"Ultrastructural characterization\nand three-dimensional\narchitecture of replication sites in dengue virus-infected mosquito\ncells","volume":"88","author":"Junjhon","year":"2014","journal-title":"J. Virol."},{"key":"2026092210583809100_cit39","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.48469","article-title":"The ER\nmembrane protein complex is\nrequired to ensure correct topology and stable expression of flavivirus\npolyproteins","volume":"8","author":"Ngo","year":"2019","journal-title":"eLife"},{"issue":"18","key":"2026092210583809100_cit40","doi-asserted-by":"publisher","first-page":"9789","DOI":"10.1093\/nar\/gkz686","article-title":"Circularization\nof flavivirus genomic RNA inhibits de novo translation initiation","volume":"47","author":"Sanford","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"16","key":"2026092210583809100_cit41","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1101\/gad.1444206","article-title":"A 5\u2032 RNA\nelement promotes dengue virus RNA synthesis\non a circular genome","volume":"20","author":"Filomatori","year":"2006","journal-title":"Genes Dev."},{"issue":"5","key":"2026092210583809100_cit42","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00934-23","article-title":"PKR-mediated\nstress response enhances dengue and Zika virus replication","volume":"14","author":"Ricciardi-Jorge","year":"2023","journal-title":"mBio"},{"issue":"1","key":"2026092210583809100_cit43","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02150-16","article-title":"Flavivirus Infection\nUncouples Translation Suppression from Cellular Stress Responses","volume":"8","author":"Roth","year":"2017","journal-title":"mBio"},{"key":"2026092210583809100_cit44","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14762","article-title":"Structure and function of the Zika\nvirus full-length NS5 protein","volume":"8","author":"Zhao","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"2026092210583809100_cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22846-1","article-title":"Structures of flavivirus\nRNA promoters suggest two binding modes with NS5 polymerase","volume":"12","author":"Lee","year":"2021","journal-title":"Nat. Commun."},{"issue":"8","key":"2026092210583809100_cit46","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1261\/rna.080342.124","article-title":"Structural and functional\ncharacterization of the SLA\u2019 structure at the 3\u2032 terminus\nof the Zika virus negative-strand intermediate","volume":"31","author":"Abram","year":"2025","journal-title":"RNA"},{"key":"2026092210583809100_cit47","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2018.00057","article-title":"Three-Dimensional Architecture and Biogenesis of Membrane Structures\nAssociated with Plant Virus Replication","volume":"9","author":"Jin","year":"2018","journal-title":"Front.\nPlant Sci."},{"issue":"2","key":"2026092210583809100_cit48","doi-asserted-by":"publisher","first-page":"32","DOI":"10.5501\/wjv.v2.i2.32","article-title":"Architecture\nand biogenesis of plus-strand RNA virus\nreplication factories","volume":"2","author":"Paul","year":"2013","journal-title":"World J. Virol."},{"issue":"17","key":"2026092210583809100_cit49","doi-asserted-by":"publisher","first-page":"8470","DOI":"10.1128\/JVI.00176-10","article-title":"Tick-Borne Encephalitis\nVirus Delays Interferon Induction and Hides Its Double-Stranded RNA\nin Intracellular Membrane Vesicles","volume":"84","author":"O\u0308verby","year":"2010","journal-title":"J. Virol."},{"issue":"6","key":"2026092210583809100_cit50","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.chom.2008.10.007","article-title":"A highly structured,\nnuclease-resistant, noncoding RNA produced by flaviviruses is required\nfor pathogenicity","volume":"4","author":"Pijlman","year":"2008","journal-title":"Cell Host Microbe"},{"key":"2026092210583809100_cit51","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.antiviral.2018.09.006","article-title":"Subgenomic flaviviral RNAs: What do we know after the\nfirst decade of research","volume":"159","author":"Slonchak","year":"2018","journal-title":"Antiviral Res."},{"key":"2026092210583809100_cit52","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01892","article-title":"RNA structures that\nresist degradation by Xrn1 produce a pathogenic Dengue virus RNA","volume":"3","author":"Chapman","year":"2014","journal-title":"eLife"},{"issue":"6257","key":"2026092210583809100_cit53","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1126\/science.aab3369","article-title":"Dengue\nsubgenomic RNA\nbinds TRIM25 to inhibit interferon expression for epidemiological\nfitness","volume":"350","author":"Manokaran","year":"2015","journal-title":"Science"},{"issue":"7","key":"2026092210583809100_cit54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004242","article-title":"G3BP1,\nG3BP2 and CAPRIN1 are required\nfor translation of interferon stimulated mRNAs and are targeted by\na dengue virus non-coding RNA","volume":"10","author":"Bidet","year":"2014","journal-title":"PLoS Pathog."},{"issue":"6316","key":"2026092210583809100_cit55","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1126\/science.aah3963","article-title":"Zika virus produces noncoding RNAs using a multi-pseudoknot\nstructure that confounds a cellular exonuclease","volume":"354","author":"Akiyama","year":"2016","journal-title":"Science"},{"issue":"44","key":"2026092210583809100_cit56","doi-asserted-by":"publisher","first-page":"16282","DOI":"10.1074\/jbc.RA119.009129","article-title":"Zika virus noncoding\nsfRNAs sequester multiple host-derived RNA-binding proteins and modulate\nmRNA decay and splicing during infection","volume":"294","author":"Michalski","year":"2019","journal-title":"J.\nBiol. Chem."},{"issue":"11","key":"2026092210583809100_cit57","doi-asserted-by":"publisher","first-page":"6469","DOI":"10.1128\/JVI.03456-12","article-title":"Three-Dimensional Architecture\nof\nTick-Borne Encephalitis Virus Replication Sites and Trafficking of\nthe Replicated RNA","volume":"87","author":"Miorin","year":"2013","journal-title":"J. Virol."},{"issue":"3","key":"2026092210583809100_cit58","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13030240","article-title":"Viral Infections,\nAre They a Trigger and Risk Factor of Alzheimer\u2019s Disease?","volume":"13","author":"Rippee-Brooks","year":"2024","journal-title":"Pathogens"},{"issue":"1","key":"2026092210583809100_cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36838-w","article-title":"Zika virus RNA structure\ncontrols its unique neurotropism by bipartite binding to Musashi-1","volume":"14","author":"Chen","year":"2023","journal-title":"Nat. Commun."},{"key":"2026092210583809100_cit60","doi-asserted-by":"crossref","unstructured":"Eldin, P.; Bernard, E.; V\u00e5gb\u00f8, C. B.; George, L.; Ajiro, M.; Hagiwara, M.; Slupphaug, G.; Briant, L.\n          Zika virus reprograms the host\ntRNA epitranscriptome to adapt translation to A-ending codon bias\n          bioRxiv\n          2025\n          10.1101\/2025.06.03.657606.","DOI":"10.1101\/2025.06.03.657606"},{"issue":"4","key":"2026092210583809100_cit61","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1261\/rna.049825.115","article-title":"Post-transcriptional\nmodifications\nto tRNA--a response to the genetic code degeneracy","volume":"21","author":"Hou","year":"2015","journal-title":"RNA"},{"issue":"3","key":"2026092210583809100_cit62","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9030158","article-title":"Crosstalk\nbetween RNA Metabolism and Cellular Stress Responses during Zika Virus\nReplication","volume":"9","author":"Oyarzu\u0301n-Arrau","year":"2020","journal-title":"Pathogens"},{"issue":"23","key":"2026092210583809100_cit63","doi-asserted-by":"publisher","first-page":"13821","DOI":"10.1128\/JVI.02505-14","article-title":"Overlapping and Distinct Molecular\nDeterminants Dictating the Antiviral Activities of TRIM56 against\nFlaviviruses and Coronavirus","volume":"88","author":"Liu","year":"2014","journal-title":"J. Virol."},{"issue":"6","key":"2026092210583809100_cit64","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/s41594-023-00990-0","article-title":"Molecular basis of the TRAP complex\nfunction in ER protein biogenesis","volume":"30","author":"Jaskolowski","year":"2023","journal-title":"Nat. Struct.\nMol. Biol."},{"issue":"3","key":"2026092210583809100_cit65","doi-asserted-by":"publisher","first-page":"162","DOI":"10.24920\/004393","article-title":"Polypyrimidine Tract-Binding Protein\nEnhances Zika Virus Translation by Binding to the 5\u2019UTR of\nInternal Ribosomal Entry Site","volume":"39","author":"Moliduer","year":"2024","journal-title":"Chin. Med. Sci.\nJ."},{"issue":"6","key":"2026092210583809100_cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102189","article-title":"The human neural cell atlas of Zika\nvirus infection in developing brain tissue","volume":"6","author":"Stokes","year":"2025","journal-title":"Cell Rep. Med."},{"issue":"10","key":"2026092210583809100_cit67","doi-asserted-by":"publisher","DOI":"10.3390\/v12101177","article-title":"Disruption\nof Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific\nAttenuated Viral Replication","volume":"12","author":"Sparks","year":"2020","journal-title":"Viruses"},{"issue":"1","key":"2026092210583809100_cit68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011070","article-title":"Nuclear\naccumulation of host transcripts during Zika\nVirus Infection","volume":"19","author":"Leon","year":"2023","journal-title":"PLoS Pathog."},{"issue":"7","key":"2026092210583809100_cit69","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005775","article-title":"Zika virus inhibits\neIF2\u03b1-dependent stress granule assembly","volume":"11","author":"Amorim","year":"2017","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"6","key":"2026092210583809100_cit70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012355","article-title":"The NS2B-PP1\u03b1-eIF2\u03b1\naxis: Inhibiting stress granule formation and Boosting Zika virus\nreplication","volume":"20","author":"Wu","year":"2024","journal-title":"PLoS Pathog."},{"issue":"3","key":"2026092210583809100_cit71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006295","article-title":"Correction:\nG3BP1, G3BP2 and CAPRIN1\nAre Required for Translation of Interferon Stimulated mRNAs and Are\nTargeted by a Dengue Virus Non-coding RNA","volume":"13","author":"Bidet","year":"2017","journal-title":"PLoS\nPathog."},{"issue":"7","key":"2026092210583809100_cit72","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1016\/j.cell.2018.11.028","article-title":"Comparative Flavivirus-Host\nProtein Interaction Mapping Reveals Mechanisms of Dengue and Zika\nVirus Pathogenesis","volume":"175","author":"Shah","year":"2018","journal-title":"Cell"},{"issue":"7722","key":"2026092210583809100_cit73","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/s41586-018-0484-5","article-title":"An orthogonal\nproteomic survey uncovers novel Zika\nvirus host factors","volume":"561","author":"Scaturro","year":"2018","journal-title":"Nature"},{"issue":"12","key":"2026092210583809100_cit74","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00520-19","article-title":"Zika Virus Subverts\nStress Granules To Promote and\nRestrict Viral Gene Expression","volume":"93","author":"Bonenfant","year":"2019","journal-title":"J. Virol."},{"issue":"16","key":"2026092210583809100_cit75","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00474-17","article-title":"Zika Virus\nHijacks\nStress Granule Proteins and Modulates the Host Stress Response","volume":"91","author":"Hou","year":"2017","journal-title":"J. Virol."},{"issue":"3","key":"2026092210583809100_cit76","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00361-21","article-title":"Zika Virus Induces an Atypical Tripartite\nUnfolded Protein Response with Sustained Sensor and Transient Effector\nActivation and a Blunted BiP Response","volume":"6","author":"Mufrrih","year":"2021","journal-title":"mSphere"},{"key":"2026092210583809100_cit77","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00094","article-title":"The Unfolded\nProtein Response: A Key Player in Zika Virus-Associated Congenital\nMicrocephaly","volume":"13","author":"Alfano","year":"2019","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"2026092210583809100_cit78","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1311-5","article-title":"ZIKV infection activates the IRE1-XBP1 and ATF6 pathways\nof unfolded protein response in neural cells","volume":"15","author":"Tan","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"2026092210583809100_cit79","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41593-017-0038-4","article-title":"Stress-induced unfolded protein response contributes\nto Zika virus-associated microcephaly","volume":"21","author":"Gladwyn-Ng","year":"2018","journal-title":"Nat.\nNeurosci."},{"key":"2026092210583809100_cit80","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00709","article-title":"Translational\nControl in Stem Cells","volume":"9","author":"Tahmasebi","year":"2019","journal-title":"Front. Genet."},{"issue":"7","key":"2026092210583809100_cit81","doi-asserted-by":"publisher","DOI":"10.3390\/v14071418","article-title":"Transcriptional and\nTranslational Dynamics of Zika\nand Dengue Virus Infection","volume":"14","author":"Singh","year":"2022","journal-title":"Viruses"},{"issue":"18","key":"2026092210583809100_cit82","doi-asserted-by":"publisher","first-page":"11128","DOI":"10.1093\/nar\/gkae507","article-title":"Zika virus non-coding\nRNAs antagonize antiviral responses by PKR-mediated translational\narrest","volume":"52","author":"Pallare\u0301s","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"2026092210583809100_cit83","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.stem.2016.04.014","article-title":"Zika Virus Depletes\nNeural Progenitors\nin Human Cerebral Organoids through Activation of the Innate Immune\nReceptor TLR3","volume":"19","author":"Dang","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"5","key":"2026092210583809100_cit84","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.stem.2016.07.019","article-title":"Zika\nVirus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human\nFetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy","volume":"19","author":"Liang","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"6","key":"2026092210583809100_cit85","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.chom.2016.05.009","article-title":"Zika Virus\nTargets Human STAT2 to Inhibit Type I Interferon Signaling","volume":"19","author":"Grant","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"20","key":"2026092210583809100_cit86","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika Virus and Birth\nDefects--Reviewing the Evidence for Causality","volume":"374","author":"Rasmussen","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2026092210583809100_cit87","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ebiom.2016.07.018","article-title":"Comparative Analysis\nBetween Flaviviruses\nReveals Specific Neural Stem Cell Tropism for Zika Virus in the Mouse\nDeveloping Neocortex","volume":"10","author":"Brault","year":"2016","journal-title":"EBioMedicine"},{"issue":"5","key":"2026092210583809100_cit88","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.stem.2016.03.012","article-title":"Expression\nAnalysis Highlights AXL\nas a Candidate Zika Virus Entry Receptor in Neural Stem Cells","volume":"18","author":"Nowakowski","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"2","key":"2026092210583809100_cit89","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.celrep.2016.12.045","article-title":"Axl Mediates ZIKA Virus\nEntry in Human Glial Cells and Modulates Innate Immune Responses","volume":"18","author":"Meertens","year":"2017","journal-title":"Cell Rep."},{"issue":"6287","key":"2026092210583809100_cit90","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1126\/science.aaf6116","article-title":"Zika virus\nimpairs growth in human\nneurospheres and brain organoids","volume":"352","author":"Garcez","year":"2016","journal-title":"Science"},{"issue":"1","key":"2026092210583809100_cit91","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.stem.2016.04.017","article-title":"Zika Virus\nDisrupts Neural Progenitor Development and Leads to Microcephaly in\nMice","volume":"19","author":"Li","year":"2016","journal-title":"Cell Stem Cell"},{"key":"2026092210583809100_cit92","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.virol.2016.11.002","article-title":"Cytoarchitecture\nof Zika virus infection in human neuroblastoma and Aedes albopictus\ncell lines","volume":"501","author":"Offerdahl","year":"2017","journal-title":"Virology"},{"issue":"49","key":"2026092210583809100_cit93","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2205013119","article-title":"The RNA\npolymerase of cytoplasmically replicating Zika virus binds with chromatin\nDNA in nuclei and regulates host gene transcription","volume":"119","author":"Li","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"2026092210583809100_cit94","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56927-2","article-title":"Zika virus\nNS1 drives tunneling nanotube formation for mitochondrial transfer\nand stealth transmission in trophoblasts","volume":"16","author":"Michita","year":"2025","journal-title":"Nat.\nCommun."},{"issue":"12","key":"2026092210583809100_cit95","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01085-23","article-title":"Visualizing the\nvirus world inside the cell by cryo-electron\ntomography","volume":"98","author":"Zhou","year":"2024","journal-title":"J. Virol."},{"issue":"1","key":"2026092210583809100_cit96","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-68483-4","article-title":"Cryo-electron tomography\nreveals coupled flavivirus\nreplication, budding and maturation","volume":"17","author":"Dahmane","year":"2026","journal-title":"Nat. Commun."},{"issue":"12","key":"2026092210583809100_cit97","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1038\/s41592-019-0403-1","article-title":"Deep learning\nfor cellular image analysis","volume":"16","author":"Moen","year":"2019","journal-title":"Nat. Methods"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c04495","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/37\/54793\/68451893\/acsomega.6c04495.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/37\/54793\/68451893\/acsomega.6c04495.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:44:14Z","timestamp":1790091854000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/37\/54793\/5426571\/Spatial-Coupling-of-Viral-RNA-Translation-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":97,"journal-issue":{"issue":"37","published-online":{"date-parts":[[2026,9,8]]},"published-print":{"date-parts":[[2026,9,22]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c04495","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]}}}