{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:56:53Z","timestamp":1791302213493,"version":"4.1.0"},"reference-count":72,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014434","name":"Narodowa Agencja Wymiany Akademickiej","doi-asserted-by":"publisher","award":["PN\/BIT\/2024\/1\/00027\/U\/00001"],"award-info":[{"award-number":["PN\/BIT\/2024\/1\/00027\/U\/00001"]}],"id":[{"id":"10.13039\/501100014434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2017\/26\/M\/NZ7\/01048"],"award-info":[{"award-number":["2017\/26\/M\/NZ7\/01048"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multiple lines of evidence highlight the impact of the resolution of inflammation (RoI) on mitigating the inflammatory response and restoring homeostasis in the brain. Recently, the significance of formyl peptide receptor 2 (FPR2) in this process has been emphasized due to its remarkable ability to interact with a wide range of ligands, including specialized proresolving mediators (SPMs). Although these endogenous molecules, such as lipoxin A4 (LXA4), exhibit beneficial effects, their unfavorable pharmacokinetic properties result in rapid chemical inactivation. Hence, in the present study, we examined the proresolving and anti-inflammatory properties of LXA4 and two potent FPR2 agonists, namely, compounds CMC23 and MR-39. For this purpose, we conducted time-dependent behavioral and biochemical studies in selected brain areas of adult male rats by using a systemic immunoactivation model. We reported that LXA4 and CMC23 abolished behavioral disturbances evoked by lipopolysaccharide (LPS) administration; however, only CMC23 exhibited long-lasting beneficial properties on these impairments. In the biochemical part of our study, endogenous LXA4 showed beneficial effects but mostly 1 h after i.c.v. administration. The strong and prolonged proresolving potency of CMC23 was evidenced by the attenuation of proinflammatory cytokine release (IL-1\u03b2, IL-6, TNF-\u03b1) in both examined structures. Moreover, the proresolving effect of MR-39 administration was evident only in the biochemical part of the experiments. These findings provide new in vivo evidence that ureidopropanamide FPR2 agonists, especially CMC23, exert protective and anti-inflammatory actions; thus, FPR2 may be proposed as a promising target for RoI improvement.<\/jats:p>","DOI":"10.1021\/acsomega.6c04547","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:02:01Z","timestamp":1789988521000},"page":"59425-59437","source":"Crossref","is-referenced-by-count":0,"title":["Treatment with\nUreidopropanamide Formyl Peptide Receptor\n2 Agonists Attenuates Brain Changes Induced by Systemic Lipopolysaccharide\nAdministration in Rats"],"prefix":"10.1021","volume":"11","author":[{"given":"Kinga","family":"Tylek","sequence":"first","affiliation":[{"name":"Polish Academy of Sciences , , 12 Sme\u0328tna St. , ,","place":["Krako\u0301w, Poland, 31-343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Kamin\u0301ska","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences , , 12 Sme\u0328tna St. , ,","place":["Krako\u0301w, Poland, 31-343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Trojan","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences , , 12 Sme\u0328tna St. , ,","place":["Krako\u0301w, Poland, 31-343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Frydrych","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences , , 12 Sme\u0328tna St. , ,","place":["Krako\u0301w, Poland, 31-343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Les\u0301kiewicz","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences , , 12 Sme\u0328tna St. , ,","place":["Krako\u0301w, Poland, 31-343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Regulska","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences , , 12 Sme\u0328tna St. , ,","place":["Krako\u0301w, Poland, 31-343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Curzytek-Malicka","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences , , 12 Sme\u0328tna St. , ,","place":["Krako\u0301w, Poland, 31-343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Wydra-Kolarska","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences , , 12 Sme\u0328tna St. , ,","place":["Krako\u0301w, Poland, 31-343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8401-2815","authenticated-orcid":true,"given":"Marcello","family":"Leopoldo","sequence":"additional","affiliation":[{"name":"University of Bari , , Via Orabona 4 , ,","place":["Bari, Italy, 70125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2443-1174","authenticated-orcid":true,"given":"Enza","family":"Lacivita","sequence":"additional","affiliation":[{"name":"University of Bari , , Via Orabona 4 , ,","place":["Bari, Italy, 70125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3109-0040","authenticated-orcid":true,"given":"Agnieszka","family":"Basta-Kaim","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences , , 12 Sme\u0328tna St. , ,","place":["Krako\u0301w, Poland, 31-343"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"issue":"7503","key":"2026100610472777800_cit1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving\nlipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"2026100610472777800_cit2","doi-asserted-by":"publisher","first-page":"107879","DOI":"10.1016\/j.pharmthera.2021.107879","article-title":"Resolution of Inflammation:\nAn Organizing Principle in Biology and Medicine","volume":"227","author":"Panigrahy","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"2026100610472777800_cit3","doi-asserted-by":"publisher","first-page":"229","DOI":"10.2174\/1570159X17666191019170244","article-title":"The Contribution of Formyl Peptide Receptor Dysfunction\nto the Course of Neuroinflammation: A Potential Role in the Brain\nPathology","volume":"18","author":"Trojan","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"2026100610472777800_cit4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/3267172","article-title":"Resolution of Inflammation in Neurodegenerative\nDiseases: The Role of Resolvins","volume":"2020","author":"Chamani","year":"2020","journal-title":"Mediators Inflammation"},{"issue":"1","key":"2026100610472777800_cit5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/embj.201386609","article-title":"The Resolution of Neuroinflammation\nin Neurodegeneration:\nLeukocyte Recruitment via the Choroid Plexus","volume":"33","author":"Schwartz","year":"2014","journal-title":"EMBO J."},{"issue":"5","key":"2026100610472777800_cit6","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/emmm.201202382","article-title":"Resolution of Inflammation: An Integrated\nView","volume":"5","author":"Ortega-Go\u0301mez","year":"2013","journal-title":"EMBO Mol. 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Rep."},{"issue":"10","key":"2026100610472777800_cit42","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1111\/cns.13906","article-title":"Effects of Intraperitoneal\nInjection of Lipopolysaccharide-induced\nPeripheral Inflammation on Dopamine Neuron Damage in Rat Midbrain","volume":"28","author":"Yang","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"2026100610472777800_cit43","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.bcp.2016.05.008","article-title":"Beneficial\nImpact of Intracerebroventricular Fractalkine Administration on Behavioral\nand Biochemical Changes Induced by Prenatal Stress in Adult Rats:\nPossible Role of NLRP3 Inflammasome Pathway","volume":"113","author":"S\u0301lusarczyk","year":"2016","journal-title":"Biochem. 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Neuropsychopharmacol."},{"issue":"1","key":"2026100610472777800_cit45","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active Behaviors\nin the Rat Forced\nSwimming Test Differentially Produced by Serotonergic and Noradrenergic\nAntidepressants","volume":"121","author":"Detke","year":"1995","journal-title":"Psychopharmacology"},{"issue":"8","key":"2026100610472777800_cit46","doi-asserted-by":"publisher","first-page":"5365","DOI":"10.1007\/s12035-018-1458-1","article-title":"Role of Chronic\nAdministration of\nAntidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response\nin the Brain of Adult Offspring Rats: Involvement of the NLRP3 Inflammasome-Related\nPathway","volume":"56","author":"Trojan","year":"2019","journal-title":"Mol. 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