{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:06:54Z","timestamp":1788876414733,"version":"build-2803163510"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016003","name":"Istanbul ?niversitesi-Cerrahpasa","doi-asserted-by":"publisher","award":["FYL-2024-37579"],"award-info":[{"award-number":["FYL-2024-37579"]}],"id":[{"id":"10.13039\/501100016003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Traumatic injuries and uncontrolled, intense bleeding caused by surgery remain among today\u2019s leading medical problems. Traumatic wounds are not only observed on the skin but also result from internal organ ruptures caused by explosions and firearms. At this point, severe hemorrhaging can lead to hypothermia, hemorrhagic shock, organ failure, and even death due to the loss of more than 40% of blood volume. Therefore, it is crucial to halt bleeding rapidly. In this study, an alginate derivative that supports platelet aggregation and a hyaluronic acid derivative that adheres to wet tissues and induces angiogenesis, thereby promoting vascularization, have been prepared. The derivatives of alginate and hyaluronic acid were subjected to free radical photopolymerization, allowing them to cross-link in the presence of visible light. The study aims to introduce a new biomaterial featuring sodium alginate and hyaluronic acid groups that demonstrates good mechanical strength, a high swelling capacity to stabilize bleeding in the environment, and effective hemostatic properties. The chemical characterization of biopolymers was analyzed using FTIR and NMR techniques. The mechanical properties, swelling behavior, and degradation profiles of visible light cross-linked hybrid hydrogels were systematically characterized. The biocompatibility of the produced hydrogels was also evaluated using MTT and scratch wound healing tests. In addition, hemolysis and blood coagulation tests were performed to investigate the hemocompatibility and hemostatic potential of visible light cross-linked hybrid hydrogels.<\/jats:p>","DOI":"10.1021\/acsomega.6c04561","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:36:04Z","timestamp":1788266164000},"page":"52855-52866","source":"Crossref","is-referenced-by-count":0,"title":["Development of\nDual-Cross-Linked AlgMA\/HAMA Hybrid\nHydrogels for Traumatic Wound Healing"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7532-216X","authenticated-orcid":true,"given":"Simay Y.","family":"Rivas Rodriguez","sequence":"first","affiliation":[{"name":"Istanbul University-Cerrahpasa , , ,","place":["Istanbul, Turkey, 34320"]},{"name":"Eskisehir Technical University , , ,","place":["Eskisehir, Turkey, 26555"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alime","family":"Sar\u0131kaya","sequence":"additional","affiliation":[{"name":"Bezmialem Vak\u0131f University , , ,","place":["Istanbul, Turkey, 34093"]},{"name":"Bezmialem Vakif University Experimental Application and Research Center Cell Culture Laboratory , ,","place":["Istanbul, Turkey, 34093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Su","sequence":"additional","affiliation":[{"name":"Istanbul University , , ,","place":["Istanbul, Turkey, 34134"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-1265","authenticated-orcid":true,"given":"Cemal","family":"O\u0308zerog\u0306lu","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa , , ,","place":["Istanbul, Turkey, 34320"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"2026090809094059100_cit1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202100475","article-title":"Progress in\nHydrogels for Skin Wound Repair","volume":"22","author":"Qi","year":"2022","journal-title":"Macromol. 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Healthcare Mater."},{"key":"2026090809094059100_cit5","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkab019","article-title":"Hemostatic materials\nin wound care","volume":"9","author":"Yu","year":"2021","journal-title":"Burns Trauma"},{"issue":"2","key":"2026090809094059100_cit6","doi-asserted-by":"publisher","DOI":"10.3390\/ma17020278","article-title":"Designing Composite Stimuli-Responsive\nHydrogels for\nWound Healing Applications: The State-of-the-Art and Recent Discoveries","volume":"17","author":"Michalicha","year":"2024","journal-title":"Materials"},{"issue":"3","key":"2026090809094059100_cit7","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1080\/09205063.2023.2289247","article-title":"The efficient\nrole of sodium alginate-based biodegradable dressings for skin wound\nhealing application: a systematic review","volume":"35","author":"da Silva","year":"2024","journal-title":"J.\nBiomater. Sci., Polym. Ed."},{"issue":"4","key":"2026090809094059100_cit8","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1021\/bm3019856","article-title":"Synthesis\nand characterization of hybrid hyaluronic acid-gelatin hydrogels","volume":"14","author":"Camci-Unal","year":"2013","journal-title":"Biomacromolecules"},{"issue":"9","key":"2026090809094059100_cit9","doi-asserted-by":"publisher","DOI":"10.1002\/app.53559","article-title":"Polymer in hemostasis\nand follow-up wound healing","volume":"140","author":"Sasmal","year":"2023","journal-title":"J. Appl. Polymer\nSci."},{"key":"2026090809094059100_cit10","doi-asserted-by":"publisher","first-page":"7148","DOI":"10.1039\/D2TB00591C","article-title":"Bioactive hydrogels based on polysaccharides\nand peptides for soft tissue wound management","volume":"10","author":"Wu","year":"2022","journal-title":"J. Mater. Chem. 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Macromol."},{"key":"2026090809094059100_cit32","doi-asserted-by":"publisher","DOI":"10.3390\/gels11040234","article-title":"Applications\nof Hydrogels in Emergency\nTherapy","volume":"11","author":"Chelu","year":"2025","journal-title":"Gels"},{"key":"2026090809094059100_cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123244","article-title":"Hyaluronic\nacid\/alginate-based biomimetic hydrogel membranes for accelerated\ndiabetic wound repair","volume":"643","author":"Khaliq","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"8","key":"2026090809094059100_cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127612","article-title":"Self-healing hydrogels based on biological\nmacromolecules in wound healing: A review","volume":"253","author":"Yang","year":"2023","journal-title":"Int.\nJ. Biol. Macromol."},{"key":"2026090809094059100_cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.131506","article-title":"Remodeling\nmicroenvironment based on MOFs-Hydrogel\nhybrid system for improving diabetic wound healing","volume":"427","author":"Yang","year":"2022","journal-title":"Chem. Eng. J."},{"issue":"11","key":"2026090809094059100_cit36","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1080\/00914037.2023.2235875","article-title":"Photocrosslinked methacrylated\npectin and methacrylated hyaluronic acid wound dressing loaded with\noleuropein as bioactive agent","volume":"73","author":"Moran Bozer","year":"2024","journal-title":"Int. J. Polym.\nMater. Polym. Biomater."},{"key":"2026090809094059100_cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122565","article-title":"Efficient delivery\nof VEGF-A mRNA for promoting diabetic wound healing via ionizable\nlipid nanoparticles","volume":"632","author":"Wenhui","year":"2023","journal-title":"Int. J. Pharm."},{"key":"2026090809094059100_cit38","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.700","article-title":"Biomimetic Triplet Messenger RNA\nFormulation in MXene Hydrogel Microneedles for Wound Healing","volume":"6","author":"Wang","year":"2025","journal-title":"Aggregate"},{"key":"2026090809094059100_cit39","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0167-7799(90)90139-O","article-title":"Alginate as immobilization\nmatrix for cells","volume":"8","author":"Smidsrod","year":"1990","journal-title":"Trends Biotechnol."},{"issue":"2","key":"2026090809094059100_cit40","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1021\/acsomega.5c03076","article-title":"Preclinical Evaluation of Colisorb:\nSurfactant-Free\nHydrophilic Gelatin Sponge with Rapid Clotting and Enhanced Absorbency\nwithout Mechanical Compression","volume":"11","author":"Hassan","year":"2026","journal-title":"ACS Omega"},{"key":"2026090809094059100_cit41","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8120215","article-title":"Control of Blood Coagulation\nby Hemocompatible Material Surfaces\u2500A Review","volume":"8","author":"Kuchinka","year":"2021","journal-title":"Bioengineering"},{"issue":"45","key":"2026090809094059100_cit42","doi-asserted-by":"publisher","first-page":"61503","DOI":"10.1021\/acsami.4c07108","article-title":"Emerging Frontiers in In Situ Forming\nHydrogels for\nEnhanced Hemostasis and Accelerated Wound Healing","volume":"16","author":"Sarkhel","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"4","key":"2026090809094059100_cit43","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1080\/15583724.2017.1315433","article-title":"Hyaluronic Acid-Based\nBiomaterials: A Versatile and Smart Approach to Tissue Regeneration\nand Treating Traumatic, Surgical, and Chronic Wounds","volume":"57","author":"Hussain","year":"2017","journal-title":"Polym. Rev."},{"key":"2026090809094059100_cit44","doi-asserted-by":"publisher","DOI":"10.3390\/gels8020109","article-title":"Application of Alginate-Based\nHydrogels\nin Hemostasis","volume":"8","author":"Xie","year":"2022","journal-title":"Gels"},{"issue":"Part 1","key":"2026090809094059100_cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.129141","article-title":"Development of alginate\nmacroporous hydrogels using sacrificial CaCO3 particles for enhanced\nhemostasis","volume":"259","author":"Wang","year":"2024","journal-title":"Inter. J. Biol. 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