{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:09:08Z","timestamp":1790698148704,"version":"4.1.0"},"reference-count":73,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo","doi-asserted-by":"publisher","award":["2022\/02992-0"],"award-info":[{"award-number":["2022\/02992-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Microbial biostimulants, bioinputs based on microorganisms, have emerged as an alternative to increase crop yield and quality while reducing the environmental impact. Particularly, the plant growth-promoting bacterium Pseudomonas fluorescens exhibits high potential for application in this field due to its production of a range of specialized metabolites (SMs). Research in this area mainly focuses on the use of active bacterial cells, whose efficacy depends on the success of host colonization. In this regard, we evaluated the treatment effect of two bioinputs from P. fluorescens ATCC_13525 (with active and inactive bacterial cells) on Micro-Tom tomato growth, productivity, nutrient accumulation, and metabolism. The bioinput with active bacterial cells promoted a few beneficial effects on the plant, the main one being associated with an increase in the calcium (Ca) concentration in fruits through foliar application. The cell-free bioinput primarily promoted an increase in leaf area, root biomass, and phosphorus (P) and molybdenum (Mo) concentrations in fruits. Specifically, its application by the foliar method exhibited a balance between the Brix degree and the maintenance of productivity. Untargeted metabolomic analysis of tomato leaves treated with this method indicated modulation of phenolamides and glycerophospholipids. On the other hand, an increase in the abundance of tryptophan and the indole lycoperodine-1 occurred when the treatment was carried out via soil. The results highlight that the cell-free formulation modulates plant responses and enhances plant performance in certain aspects under the evaluated application conditions, suggesting an important biostimulant effect of the metabolites present in the cell-free microbial culture for growth promotion and improvement in fruit quality. Notably, the findings demonstrate that microbial metabolites alone can drive significant plant responses, opening new perspectives for next-generation bioinputs in sustainable agriculture.<\/jats:p>","DOI":"10.1021\/acsomega.6c04589","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:01:44Z","timestamp":1789394504000},"page":"57072-57084","source":"Crossref","is-referenced-by-count":0,"title":["Integrative Metabolomic\nand Agronomic Analyses Reveal\nthe Impact of\n                    <i>Pseudomonas fluorescens<\/i>\n                    -Based Bioinputs on the Micro-Tom Tomato (\n                    <i>Solanum lycopersicum<\/i>\n                    ) Model System"],"prefix":"10.1021","volume":"11","author":[{"given":"Stephanie Nemesio","family":"da Silva","sequence":"first","affiliation":[{"name":"University of Campinas , , , ,","place":["Campinas, Sa\u0303o Paulo, Brazil, 13083-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Alberto","family":"Repke","sequence":"additional","affiliation":[{"name":"Rovensa Next , , ,","place":["Hortola\u0302ndia, Sa\u0303o Paulo, Brazil, 13186-904"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u0301zaro Eustaquio","family":"Pereira Peres","sequence":"additional","affiliation":[{"name":"University of Sa\u0303o Paulo , , , ,","place":["Piracicaba, Sa\u0303o Paulo, Brazil, 13418-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Aranda Peres","sequence":"additional","affiliation":[{"name":"University of Sa\u0303o Paulo , , , ,","place":["Piracicaba, Sa\u0303o Paulo, Brazil, 13418-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Costa Santos Rocha","sequence":"additional","affiliation":[{"name":"Rovensa Next , , ,","place":["Hortola\u0302ndia, Sa\u0303o Paulo, Brazil, 13186-904"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo da Cruz","family":"Centeno","sequence":"additional","affiliation":[{"name":"Federal University of ABC , , , ,","place":["Sa\u0303o Bernardo do Campo, Sa\u0303o Paulo, Brazil, 09606-045"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johana","family":"Rincones Pe\u0301rez","sequence":"additional","affiliation":[{"name":"Rovensa Next , , ,","place":["Hortola\u0302ndia, Sa\u0303o Paulo, Brazil, 13186-904"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taicia Pacheco","family":"Fill","sequence":"additional","affiliation":[{"name":"University of Campinas , , , ,","place":["Campinas, Sa\u0303o Paulo, Brazil, 13083-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"issue":"3","key":"2026092911084913300_cit1","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00344-023-11144-3","article-title":"Biostimulants: The Futuristic Sustainable\nApproach for Alleviating Crop Productivity and Abiotic Stress Tolerance","volume":"43","author":"Johnson","year":"2024","journal-title":"J. Plant Growth Regul"},{"key":"2026092911084913300_cit2","unstructured":"Mordor Intelligence. Biostimulants Market Size\n          https:\/\/www.mordorintelligence.com\/industry-reports\/global-plant-biostimulant-market-industry."},{"key":"2026092911084913300_cit3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fpls.2016.02049","article-title":"Biostimulants in\nPlant Science: A Global Perspective","volume":"7","author":"Yakhin","year":"2017","journal-title":"Front.\nPlant Sci"},{"key":"2026092911084913300_cit4","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fpls.2020.00040","article-title":"Editorial: Biostimulants\nin Agriculture","volume":"11","author":"Rouphael","year":"2020","journal-title":"Front.\nPlant Sci"},{"issue":"5","key":"2026092911084913300_cit5","doi-asserted-by":"publisher","first-page":"2856","DOI":"10.3390\/su13052856","article-title":"Bacterial\nPlant Biostimulants: A\nSustainable Way towards Improving Growth, Productivity, and Health\nof Crops","volume":"13","author":"Hamid","year":"2021","journal-title":"Sustainability"},{"issue":"2","key":"2026092911084913300_cit6","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.tim.2024.11.005","article-title":"Pseudomonas Fluorescens. 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Plant Sci"},{"issue":"4","key":"2026092911084913300_cit28","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s13213-010-0117-1","article-title":"Soil Beneficial Bacteria\nand Their Role in Plant Growth Promotion: A Review","volume":"60","author":"Hayat","year":"2010","journal-title":"Ann Microbiol"},{"key":"2026092911084913300_cit29","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.soilbio.2018.12.012","article-title":"Current\nOpinion and Perspectives on the Methods for\nTracking and Monitoring Plant Growth\u2013promoting Bacteria","volume":"130","author":"Rilling","year":"2019","journal-title":"Soil Biol. Biochem"},{"issue":"6","key":"2026092911084913300_cit30","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.3390\/plants10061145","article-title":"Effect of\nIndividual,\nSimultaneous and Sequential Inoculation of Pseudomonas Fluorescens and Meloidogyne Incognita on Growth, Biochemical, Enzymatic and\nNonenzymatic Antioxidants of Tomato (Solanum Lycopersicum L.)","volume":"10","author":"Noureldeen","year":"2021","journal-title":"Plants"},{"key":"2026092911084913300_cit31","doi-asserted-by":"publisher","first-page":"128306","DOI":"10.1016\/j.micres.2025.128306","article-title":"Pseudomonas Fluorescens P34 Colonization Impacts Expression Changes in\nWheat Roots, Reshapes\nRhizosphere Microbial Communities and Promotes Wheat Plant Growth","volume":"301","author":"Ai","year":"2025","journal-title":"Microbiol. 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Res. Microb.\nSci"},{"issue":"1\u20133","key":"2026092911084913300_cit48","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.pmpp.2007.09.008","article-title":"Costs and Trade-Offs\nAssociated with Induced Resistance","volume":"71","author":"Walters","year":"2007","journal-title":"Physiol.\nMol. Plant Pathol"},{"issue":"4","key":"2026092911084913300_cit49","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1007\/s42729-020-00233-x","article-title":"Pseudomonas Fluorescens and Azospirillum\nBrasilense Increase Yield and Fruit Quality of Tomato Under Field\nConditions","volume":"20","author":"Pe\u0301rez-Rodriguez","year":"2020","journal-title":"J. Soil Sci. 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