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Microwave hyperthermia, which enables noninvasive and localized thermal regulation, is attracting increasing attention as an externally triggered drug delivery strategy. In the present study, we developed an efficient method for controlling the complexation of polysaccharide nanogels or their cross-linked hydrogels and proteins. Our strategy is to use highly controlled microwave irradiation with precisely regulated frequency and power. We found that programmable microwave power delivery with temperature feedback enabled rapid and reproducible thermal processing under the tested conditions. This offers a potential strategy for protein\u2013biomaterial processing. The use of renewable polysaccharide-based nanogels, together with microwave-assisted process intensification, may provide a useful strategy for protein\u2013biomaterial processing.<\/jats:p>","DOI":"10.1021\/acsomega.6c04598","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:11:03Z","timestamp":1788401463000},"page":"54088-54096","source":"Crossref","is-referenced-by-count":0,"title":["Single-Frequency\nMicrowave-Assisted Nanogel\u2013Protein\nComplexation for Hybrid Biomaterial Fabrication"],"prefix":"10.1021","volume":"11","author":[{"given":"Yunting","family":"Ma","sequence":"first","affiliation":[{"name":"Kyoto University , , Katsura, Nishikyo-ku , ,","place":["Kyoto, Japan, 615-8510"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Takaya","sequence":"additional","affiliation":[{"name":"Teikyo University of Science , , 2-2-1 Senju-Sakuragi , , ,","place":["Adachi-ku, Tokyo, Japan, 120-0045"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Kyoto University , , Katsura, Nishikyo-ku , ,","place":["Kyoto, Japan, 615-8510"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Akiyoshi","sequence":"additional","affiliation":[{"name":"Kyoto University , , Katsura, Nishikyo-ku , ,","place":["Kyoto, Japan, 615-8510"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-5347","authenticated-orcid":true,"given":"Yoshihiro","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Kyoto University , , Katsura, Nishikyo-ku , ,","place":["Kyoto, Japan, 615-8510"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"2026091510082068900_cit1","volume-title":"Industrial Microwave\nHeating","author":"Metaxas","year":"1983"},{"issue":"2","key":"2026091510082068900_cit2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s11947-008-0136-0","article-title":"Non-Uniform Temperature\nDistribution during Microwave\nHeating of Food Materials\u2500a Review","volume":"3","author":"Vadivambal","year":"2010","journal-title":"Food\nBioprocess Technol."},{"issue":"3","key":"2026091510082068900_cit3","doi-asserted-by":"publisher","first-page":"202612","DOI":"10.70401\/bmeh.2026.0024","article-title":"Engineering Biomaterials\nfor Microwave Medicine: Physicochemical\nMechanisms and Emerging Biomedical Applications","volume":"4","author":"Song","year":"2024","journal-title":"BME Horizon"},{"issue":"9","key":"2026091510082068900_cit4","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1021\/ol025789s","article-title":"Microwave-Accelerated\nRuthenium-Catalyzed\nOlefin Metathesis","volume":"4","author":"Mayo","year":"2002","journal-title":"Org. 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