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This Review systematically surveys emerging detection strategies based on optical techniques, biosensing platforms, visual detection, and intracellular imaging. The underlying principles and performance advantages of these novel approaches are delineated, and their prospective applications in cell identification and drug screening are discussed. Finally, future directions are envisioned to encompass multimodal integration and intelligent, artificial intelligence-driven development, aiming to provide a reference for advancing the precision detection of telomerase activity.<\/jats:p>","DOI":"10.1021\/acsomega.6c04780","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:01:45Z","timestamp":1787245305000},"page":"50626-50646","source":"Crossref","is-referenced-by-count":0,"title":["Research Progress\non Telomerase Activity Assays: From\nTraditional Methods to Novel Technologies"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1649-8280","authenticated-orcid":true,"given":"Shuang","family":"He","sequence":"first","affiliation":[{"name":"Affiliated Hospital of North Sichuan Medical College , , ,","place":["Nanchong, China, 637000"]},{"name":"Cangxi People\u2019s Hospital , ,","place":["Cangxi, China, 628400"]},{"name":"North Sichuan Medical College , , ,","place":["Nanchong, China, 637000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of North Sichuan Medical College , , ,","place":["Nanchong, China, 637000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Cheng","sequence":"additional","affiliation":[{"name":"North Sichuan Medical College , , ,","place":["Nanchong, China, 637000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of North Sichuan Medical College , , ,","place":["Nanchong, China, 637000"]},{"name":"North Sichuan Medical College , , ,","place":["Nanchong, China, 637000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5143-5838","authenticated-orcid":true,"given":"Xiaowu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of North Sichuan Medical College , , ,","place":["Nanchong, China, 637000"]},{"name":"North Sichuan Medical College , , ,","place":["Nanchong, China, 637000"]},{"name":"North Sichuan Medical College , , ,","place":["Nanchong, China, 637000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"6274","key":"2026090307192095500_cit1","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/345458a0","article-title":"Telomeres shorten during ageing of\nhuman fibroblasts","volume":"345","author":"Harley","year":"1990","journal-title":"Nature"},{"issue":"5","key":"2026090307192095500_cit2","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1039\/c0cs00134a","article-title":"Chemistry\nin human telomere biology: structure, function and targeting of telomere\nDNA\/RNA","volume":"40","author":"Xu","year":"2011","journal-title":"Chem. 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