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Donepezil-loaded liquid crystalline nanodispersions (LCNs) were produced by sonication and exhibited encapsulation efficiencies of 91.3\u201397.9%, with the OA-containing formulation (LCN-2) displaying a smaller particle size (183.0 \u00b1 1.5 nm), lower polydispersity (0.183 \u00b1 0.006), and improved colloidal stability over 90 days. NMR (1H NMR, 1D NOESY\/ROESY and DOSY), molecular docking, and molecular dynamics simulations consistently demonstrated hydrophobic ion-pair formation between donepezil and oleic acid. These molecular interactions reduced drug mobility within the lipid domains, resulting in anomalous release behavior (n = 0.79), more sustained in vitro release, and an approximately 45% higher steady-state skin flux than the control donepezil solution. Overall, hydrophobic ion-pair formation with oleic acid represents an effective strategy to modulate drug release and enhance the transdermal performance of liquid crystalline nanodispersions for donepezil delivery.<\/jats:p>","DOI":"10.1021\/acsomega.6c04903","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:45:23Z","timestamp":1784328323000},"page":"49938-49953","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of Donepezil\nRelease Through Hydrophobic\nIon- Pairing with Oleic Acid in Liquid Crystalline Nanodispersions\nfor Transdermal Delivery"],"prefix":"10.1021","volume":"11","author":[{"given":"Priscila","family":"Pires da Silva","sequence":"first","affiliation":[{"name":"Federal University of Ouro Preto, UFOP , , , ,","place":["Ouro Preto, Minas Gerais, Brazil, 35400-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor 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