{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:46:10Z","timestamp":1792784770700,"version":"4.5.0"},"reference-count":54,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002980","name":"Dalian University of Technology","doi-asserted-by":"publisher","award":["82232022"],"award-info":[{"award-number":["82232022"]}],"id":[{"id":"10.13039\/501100002980","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002980","name":"Dalian University of Technology","doi-asserted-by":"publisher","award":["DUT22LAB404"],"award-info":[{"award-number":["DUT22LAB404"]}],"id":[{"id":"10.13039\/501100002980","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002980","name":"Dalian University of Technology","doi-asserted-by":"publisher","award":["DUT22RC(3)096"],"award-info":[{"award-number":["DUT22RC(3)096"]}],"id":[{"id":"10.13039\/501100002980","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002980","name":"Dalian University of Technology","doi-asserted-by":"publisher","award":["DUT24RC(3)013"],"award-info":[{"award-number":["DUT24RC(3)013"]}],"id":[{"id":"10.13039\/501100002980","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Microfluidics Technology Co., LTD","award":["12010285"],"award-info":[{"award-number":["12010285"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["52205184"],"award-info":[{"award-number":["52205184"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The rapid and nondestructive detachment of cells from culture surfaces is critical for obtaining high-quality cell populations in tissue engineering applications. Thermoresponsive coatings, such as poly(N-isopropylacrylamide) (PNIPAM), enable enzyme-free cell release; however, their practical utility is often constrained by inherently slow detachment kinetics. Here, we report a hybrid strategy that synergistically integrates surface acoustic wave (SAW) stimulation with a PNIPAM-based coating to markedly accelerate cell detachment. Under optimized conditions, this system achieves a cell detachment efficiency of up to 96% while reducing the detachment time from 39 to 9 min\u2500corresponding to a 76.9% decrease\u2500without compromising postdetachment cell viability (&amp;gt;95%). Morphological analyses and comparative studies indicate that SAW stimulation promotes rapid cell release by inducing cell-shape remodeling in concert with interfacial weakening on the PNIPAM substrate. Overall, this combined acoustic\u2013thermoresponsive platform offers an efficient, enzyme-free approach for rapid cell harvesting while preserving excellent cell viability and structural integrity.<\/jats:p>","DOI":"10.1021\/acsomega.6c04926","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:01:22Z","timestamp":1790460082000},"page":"59198-59209","source":"Crossref","is-referenced-by-count":0,"title":["SAW Accelerates\nNon-Destructive Cell Detachment from\nThermoresponsive Surfaces"],"prefix":"10.1021","volume":"11","author":[{"given":"Zhiyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]},{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanting","family":"Wang","sequence":"additional","affiliation":[{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zepeng","family":"Bao","sequence":"additional","affiliation":[{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]},{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasnain","family":"Kakakhail","sequence":"additional","affiliation":[{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]},{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Ma","sequence":"additional","affiliation":[{"name":"Dalian Minzu University , , ,","place":["Dalian, China, 116600"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Sichuan Micron Biotechnology Co., Ltd , ,","place":["Chengdu, China, 610219"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Sichuan Microfluidic Technology Co., Ltd. , ,","place":["Chengdu, China, 610219"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghe","family":"Yin","sequence":"additional","affiliation":[{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]},{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]},{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Jin","sequence":"additional","affiliation":[{"name":"Dalian Minzu University , , ,","place":["Dalian, China, 116600"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jining","family":"Sun","sequence":"additional","affiliation":[{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]},{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sichuan Micron Biotechnology Co., Ltd , ,","place":["Chengdu, China, 610219"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4975-6821","authenticated-orcid":true,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]},{"name":"Dalian University of Technology , , ,","place":["Dalian, China, 116024"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"issue":"7","key":"2026100610491470200_cit1","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.jacc.2016.05.055","article-title":"Cardiac tissue engineering: lost\nin translation or ready for translation?","volume":"68","author":"Bayes-Genis","year":"2016","journal-title":"J.\nAm. Coll Cardiol"},{"issue":"17","key":"2026100610491470200_cit2","doi-asserted-by":"publisher","first-page":"25771","DOI":"10.1021\/acsomega.6c00860","article-title":"Synthesis\nand characterization of regenerated cellulose coated with a silk fibroin\/hydroxyapatite\nscaffold for enhanced adhesion and proliferation of preosteoblast\ncells","volume":"11","author":"Khongchum","year":"2026","journal-title":"ACS Omega"},{"issue":"1","key":"2026100610491470200_cit3","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1021\/acsomega.5c05580","article-title":"Bioglass-Reinforced\nSpongin-Like Collagen Scaffolds for Osteoporotic Bone Tissue Engineering","volume":"11","author":"de Almeida Cruz","year":"2026","journal-title":"ACS Omega"},{"issue":"44","key":"2026100610491470200_cit4","doi-asserted-by":"publisher","first-page":"52703","DOI":"10.1021\/acsomega.5c06437","article-title":"Physical and\nChemical Modifications of Polymeric Surfaces to Enhance Epithelial\nCell Adhesion","volume":"10","author":"Santos","year":"2025","journal-title":"ACS Omega"},{"issue":"4","key":"2026100610491470200_cit5","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/(SICI)1097-4636(19990615)45:4&lt;355::AID-JBM10&gt;3.0.CO;2-7","article-title":"Decrease in culture\ntemperature releases monolayer endothelial cell\nsheets together with deposited fibronectin matrix from temperature-responsive\nculture surfaces","volume":"45","author":"Kushida","year":"1999","journal-title":"J. Biomed. Mater. Res"},{"key":"2026100610491470200_cit6","doi-asserted-by":"publisher","first-page":"105109","DOI":"10.1016\/j.jprot.2024.105109","article-title":"Optimal\nconditions for carrying out trypsin digestions on complex proteomes:\nFrom bulk samples to single cells","volume":"297","author":"Mansuri","year":"2024","journal-title":"J. Proteomics"},{"issue":"14","key":"2026100610491470200_cit7","doi-asserted-by":"publisher","first-page":"9523","DOI":"10.1021\/acs.analchem.0c00478","article-title":"Proteomics Using Protease Alternatives\nto Trypsin Benefits from Sequential Digestion with Trypsin","volume":"92","author":"Dau","year":"2020","journal-title":"Anal. 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Proteome Res"},{"issue":"10","key":"2026100610491470200_cit9","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.1021\/acs.analchem.0c03931","article-title":"Simple and\nsensitive method for deep\nprofiling of host cell proteins in therapeutic antibodies by combining\nultra-Low trypsin concentration digestion, long chromatographic gradients,\nand boxCar mass spectrometry acquisition","volume":"93","author":"Nie","year":"2021","journal-title":"Anal.\nChem"},{"issue":"36","key":"2026100610491470200_cit10","doi-asserted-by":"publisher","first-page":"13649","DOI":"10.1021\/acs.analchem.3c02543","article-title":"Assessing\nthe role of trypsin in quantitative plasma and single-cell proteomics\ntoward clinical application","volume":"95","author":"Woessmann","year":"2023","journal-title":"Anal. 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Bioeng"},{"issue":"3","key":"2026100610491470200_cit13","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1007\/s12257-018-0491-2","article-title":"Effective and intact\ncell detachment\nfrom a clinically ubiquitous culture flask by combining ultrasonic\nwave exposure and diluted trypsin","volume":"24","author":"Tauchi","year":"2019","journal-title":"Biotechnol.\nBioprocess Eng"},{"issue":"1","key":"2026100610491470200_cit14","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ydbio.2013.06.010","article-title":"Fibronectin\nand integrin\nalpha 5 play requisite roles in cardiac morphogenesis","volume":"381","author":"Mittal","year":"2013","journal-title":"Dev. 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Mater. Interfaces"},{"issue":"21","key":"2026100610491470200_cit20","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.1039\/C6TB00823B","article-title":"Effects of\nthermosensitive poly(N-isopropylacrylamide) on blood coagulation","volume":"4","author":"Zhang","year":"2016","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"2026100610491470200_cit21","doi-asserted-by":"publisher","first-page":"6126","DOI":"10.1038\/s41598-020-63228-9","article-title":"Poly(N-isopropylacrylamide)\nbased thin microgel films for use in cell culture applications","volume":"10","author":"Sanzari","year":"2020","journal-title":"Sci. Rep"},{"issue":"8","key":"2026100610491470200_cit22","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1080\/10601326808051910","article-title":"Solution Properties\nof Poly(N-isopropylacrylamide)","volume":"2","author":"Heskins","year":"1968","journal-title":"J. Macromol.\nSci., Part A"},{"issue":"4","key":"2026100610491470200_cit23","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0142-9612(95)93257-E","article-title":"Mechanism\nof cell detachment from temperature-modulated, hydrophilic-hydrophobic\npolymer surfaces","volume":"16","author":"Okano","year":"1995","journal-title":"Biomaterials"},{"issue":"5","key":"2026100610491470200_cit24","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/cnma.201600056","article-title":"A Facile method for\npreparing temperature-responsive cell culture surfaces by using a\nthioxanthone photoinitiator immobilized on a polystyrene surface","volume":"2","author":"Fukumori","year":"2016","journal-title":"ChemNanoMat"},{"issue":"3","key":"2026100610491470200_cit25","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.jbiosc.2020.11.003","article-title":"Detachment of RAW264.7 macrophages from a culture dish\nusing ultrasound excited by a Langevin transducer","volume":"131","author":"Kuriyama","year":"2021","journal-title":"J. Biosci. Bioeng"},{"issue":"1","key":"2026100610491470200_cit26","doi-asserted-by":"publisher","first-page":"9468","DOI":"10.1038\/s41598-020-66375-1","article-title":"Detachment of cell\nsheets from clinically ubiquitous cell culture vessels by ultrasonic\nvibration","volume":"10","author":"Imashiro","year":"2020","journal-title":"Sci. Rep"},{"issue":"49","key":"2026100610491470200_cit27","doi-asserted-by":"publisher","first-page":"26203","DOI":"10.1021\/acs.langmuir.4c03701","article-title":"Surface acoustic waves-enabled shielding fluid layers inhibit bacterial\nadhesion","volume":"40","author":"Sun","year":"2024","journal-title":"Langmuir"},{"key":"2026100610491470200_cit28","doi-asserted-by":"publisher","first-page":"156485","DOI":"10.1016\/j.cej.2024.156485","article-title":"SAW-driven directional\nclearance of bacteria on submerged surfaces","volume":"499","author":"Zhang","year":"2024","journal-title":"Chem. Eng. J"},{"issue":"11","key":"2026100610491470200_cit29","doi-asserted-by":"publisher","first-page":"4304","DOI":"10.1063\/1.1660920","article-title":"Ultrasonic\nhysteresis absorption in polymers","volume":"43","author":"Hartmann","year":"1972","journal-title":"J. Appl.\nPhys"},{"key":"2026100610491470200_cit30","doi-asserted-by":"publisher","first-page":"111624","DOI":"10.1016\/j.sna.2019.111624","article-title":"Computational and experimental analysis of droplet transportation\/jetting\nbehaviours driven by thin film surface acoustic waves","volume":"299","author":"Biroun","year":"2019","journal-title":"Sens Actuators, A"},{"issue":"3","key":"2026100610491470200_cit31","doi-asserted-by":"publisher","first-page":"035009","DOI":"10.1088\/2399-6528\/abda13","article-title":"Water droplet\nmotion under the influence of Surface Acoustic Waves (SAW)","volume":"5","author":"Insepov","year":"2021","journal-title":"J. Phys. Commun"},{"issue":"2","key":"2026100610491470200_cit32","doi-asserted-by":"publisher","first-page":"024102","DOI":"10.1063\/1.3049128","article-title":"Transmitting high power rf acoustic\nradiation via fluid couplants into superstrates for microfluidics","volume":"94","author":"Hodgson","year":"2009","journal-title":"Appl. Phys. Lett"},{"issue":"7","key":"2026100610491470200_cit33","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1039\/D0LC01293A","article-title":"Focused surface\nacoustic wave locally removes cells from culture surface","volume":"21","author":"Inui","year":"2021","journal-title":"Lab Chip"},{"issue":"6","key":"2026100610491470200_cit34","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1073\/pnas.1524813113","article-title":"Three-dimensional\nmanipulation of single cells using surface acoustic waves","volume":"113","author":"Guo","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"24","key":"2026100610491470200_cit35","doi-asserted-by":"publisher","first-page":"1902326","DOI":"10.1002\/advs.201902326","article-title":"Cell Adhesion, morphology,\nand metabolism variation via acoustic exposure within microfluidic\ncell handling systems","volume":"6","author":"Devendran","year":"2019","journal-title":"Adv. Sci"},{"issue":"11","key":"2026100610491470200_cit36","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/s42254-025-00874-w","article-title":"Mechanobiology across\ntimescales","volume":"7","author":"Cheng","year":"2025","journal-title":"Nat. Rev. Phys"},{"issue":"8","key":"2026100610491470200_cit37","doi-asserted-by":"publisher","first-page":"jcs239186","DOI":"10.1242\/jcs.239186","article-title":"FAK regulates\nactin polymerization\nduring sperm capacitation via the ERK2\/GEF-H1\/RhoA signaling pathway","volume":"133","author":"Salgado-Lucio","year":"2020","journal-title":"J. Cell Sci"},{"issue":"4","key":"2026100610491470200_cit38","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.jhep.2021.05.018","article-title":"Focal\nadhesion kinase (FAK) promotes cholangiocarcinoma development and\nprogression via YAP activation","volume":"75","author":"Song","year":"2021","journal-title":"J. Hepatol"},{"issue":"5","key":"2026100610491470200_cit39","doi-asserted-by":"publisher","first-page":"101061","DOI":"10.1016\/j.gendis.2023.06.030","article-title":"Mechanism\nand application of feedback loops formed by mechanotransduction and\nhistone modifications","volume":"11","author":"Sun","year":"2024","journal-title":"Genes Dis"},{"issue":"330","key":"2026100610491470200_cit40","doi-asserted-by":"publisher","first-page":"ra57","DOI":"10.1126\/scisignal.2004838","article-title":"A FAK-Cas-Rac-lamellipodin\nsignaling module transduces extracellular matrix stiffness into mechanosensitive\ncell cycling","volume":"7","author":"Bae","year":"2014","journal-title":"Sci. Signal"},{"issue":"10","key":"2026100610491470200_cit41","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax1909","article-title":"Nanoscale integrin\ncluster dynamics controls cellular mechanosensing via FAKY397 phosphorylation","volume":"6","author":"Cheng","year":"2020","journal-title":"Sci. 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Eng"},{"issue":"7999","key":"2026100610491470200_cit44","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/s41586-023-06991-9","article-title":"Matrix viscoelasticity promotes liver cancer progression\nin the pre-cirrhotic liver","volume":"626","author":"Fan","year":"2024","journal-title":"Nature"},{"issue":"1","key":"2026100610491470200_cit45","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.stem.2020.09.012","article-title":"Volumetric\nCompression Induces Intracellular Crowding\nto Control Intestinal Organoid Growth via Wnt\/\u03b2-Catenin Signaling","volume":"28","author":"Li","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"6","key":"2026100610491470200_cit46","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.cell.2017.10.008","article-title":"Force triggers YAP nuclear\nentry by regulating\ntransport across nuclear pores","volume":"171","author":"Elosegui-Artola","year":"2017","journal-title":"Cell"},{"issue":"6","key":"2026100610491470200_cit47","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1038\/s41556-022-00927-7","article-title":"Mechanical force application to the nucleus regulates\nnucleocytoplasmic transport","volume":"24","author":"Andreu","year":"2022","journal-title":"Nat. Cell Biol"},{"issue":"6","key":"2026100610491470200_cit48","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1007\/s12551-025-01379-7","article-title":"Magneto-mechanics\nin mechanobiology: enabling remote force transmission to cells and\nextracellular matrix","volume":"17","author":"Garcia-Gonzalez","year":"2025","journal-title":"Biophys. Rev"},{"issue":"6","key":"2026100610491470200_cit49","doi-asserted-by":"publisher","first-page":"4180","DOI":"10.1121\/10.0005197","article-title":"Acoustic streaming induced by MHz-frequency ultrasound\nextends the volume limit of cell suspension culture","volume":"149","author":"Oyama","year":"2021","journal-title":"J. Acoust. Soc. 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