{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:52:56Z","timestamp":1789487576007,"version":"build-2803163510"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007613","name":"Ankara Universitesi","doi-asserted-by":"publisher","award":["TSA-2023-2745"],"award-info":[{"award-number":["TSA-2023-2745"]}],"id":[{"id":"10.13039\/100007613","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neratinib (NER) is an irreversible tyrosine kinase inhibitor employed in the therapy of HER2-positive breast cancer. In the present research, the electrochemical oxidation of NER at a boron-doped diamond electrode (BDDE) was surveyed with particular emphasis on the act of surfactant-mediated interfacial influences. Cyclic and differential pulse voltammetry were used to characterize the oxidation behavior of NER and to establish an analytical approach for its determination. Among the explored anionic, cationic, and nonionic surfactant species, Tween 20 produced the most proper electrochemical reply, obviously augmenting the anodic peak current and improving signal stability. Electrochemical impedance spectroscopy (EIS) further represented that Tween 20 considerably revised the electrolyte\/BDDE interface, increasing the charge-transfer resistance of the ferri\/ferrocyanide redox probe from 510 to 1822 \u03a9. Importantly, this increment in interfacial resistance comprised concurrently with enhancement of the NER voltammetric response, indicating that Tween 20 does not act through a nonspecific acceleration of electron-transfer kinetics. Conversely, the monitored signal enhancement is consistent with affirmative NER\u2013surfactant interplays and a modified interfacial microenvironment that assists the electrochemical accessibility of NER. Scan-rate and pH-dependent investigations defined that NER undergoes an irreversible, predominantly diffusion-controlled oxidation involving proton-coupled electron transfer. Under the optimized experimental conditions at pH 7.02 containing 100 \u03bcM Tween 20, the DPV signal was linear the NER concentration between 0.03\u20131.50 \u03bcM (16.7\u2013836 ng mL\u20131). The limits of detection and quantification were 5.09 nM (2.84 ng mL\u20131) and 15.16 nM (8.44 ng mL\u20131), respectively. Overall, the outcomes demonstrate that the analytical enhancement of NER at BDDE originates from surfactant-mediated, analyte-specific interfacial impacts and ensure a mechanistic basis for its sensitive voltammetric determination.<\/jats:p>","DOI":"10.1021\/acsomega.6c05232","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:51:26Z","timestamp":1788439886000},"page":"54221-54233","source":"Crossref","is-referenced-by-count":0,"title":["Electrochemical\nBehavior of Neratinib at a Boron-Doped\nDiamond Electrode: Role of Tween 20 in Interfacial Signal Enhancement"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1407-622X","authenticated-orcid":true,"given":"Gu\u0308lsu\u0308m Ece","family":"Meraki","sequence":"first","affiliation":[{"name":"Ankara University , , ,","place":["Ankara, Turkiye, 06560"]},{"name":"Ankara University , , ,","place":["Ankara, Turkiye, 06110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9763-2925","authenticated-orcid":true,"given":"Hu\u0308lya","family":"Silah","sequence":"additional","affiliation":[{"name":"Bilecik Seyh Edebali University , , ,","place":["Bilecik, Turkiye, 11100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-4913","authenticated-orcid":true,"given":"Bengi","family":"Uslu","sequence":"additional","affiliation":[{"name":"Ankara University , , ,","place":["Ankara, Turkiye, 06560"]},{"name":"Ankara University , , Yapracik , Etimesgut, ,","place":["Ankara, Turkiye, 06790"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"issue":"1130","key":"2026091510083179800_cit1","doi-asserted-by":"publisher","first-page":"20211033","DOI":"10.1259\/bjr.20211033","article-title":"Understanding breast cancer as a global health concern","volume":"95","author":"Wilkinson","year":"2022","journal-title":"Br. J. Radiol."},{"issue":"17","key":"2026091510083179800_cit2","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.3390\/cancers13174287","article-title":"Breast Cancer-Epidemiology, Risk Factors, Classification,\nPrognostic Markers, and Current Treatment Strategies-An Updated Review","volume":"13","author":"\u0141ukasiewicz","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"2026091510083179800_cit3","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/annonc\/mds284","article-title":"Safety and efficacy of neratinib\n(HKI-272) plus vinorelbine\nin the treatment of patients with ErbB2-positive metastatic breast\ncancer pretreated with anti-HER2 therapy","volume":"24","author":"Awada","year":"2013","journal-title":"Ann.\nOncol."},{"key":"2026091510083179800_cit4","doi-asserted-by":"publisher","first-page":"289","DOI":"10.2147\/BTT.S3479","article-title":"HER2 breast cancer\ntherapies: A review","volume":"3","author":"Murphy","year":"2009","journal-title":"Biologics:\nTargets and Therapy"},{"key":"2026091510083179800_cit5","doi-asserted-by":"publisher","first-page":"148092","DOI":"10.1016\/j.electacta.2025.148092","article-title":"Synergistic Role of MoO3\u2013CTAB Nanostructures in\nBoosting Electrochemical Immunosensing of HER2","volume":"549","author":"Sarsenbayeva","year":"2026","journal-title":"Electrochim. Acta"},{"issue":"14","key":"2026091510083179800_cit6","doi-asserted-by":"publisher","first-page":"3305","DOI":"10.3390\/cancers14143305","article-title":"Targeted Therapeutic\nOptions and Future Perspectives\nfor HER2-Positive Breast Cancer","volume":"14","author":"Ferrando-Di\u0301ez","year":"2022","journal-title":"Cancers"},{"issue":"2","key":"2026091510083179800_cit7","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s10549-021-06217-4","article-title":"Neratinib plus capecitabine\nsustains health-related quality of life in patients with HER2-positive\nmetastatic breast cancer and \u2265 2 prior HER2-directed regimens","volume":"188","author":"Moy","year":"2021","journal-title":"Breast Cancer Res. Tr"},{"key":"2026091510083179800_cit8","first-page":"1392","article-title":"Development of an UPLC-MS\/MS validated\nmethod for determination and\npharmacokinetic study of neratinib in rat plasma","volume":"37","author":"Huang","year":"2018","journal-title":"Lat. Am. J. Pharm."},{"issue":"2","key":"2026091510083179800_cit9","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/bio.3160","article-title":"An eco-friendly direct spectrofluorimetric\nmethod for the determination of irreversible tyrosine kinase inhibitors,\nneratinib and pelitinib: application to stability studies","volume":"32","author":"Maher","year":"2017","journal-title":"Luminescence"},{"issue":"9","key":"2026091510083179800_cit10","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5416","article-title":"Hybrid\nsolid-phase extraction to overcome interference due to phospholipids\nfor determination of neratinib in human plasma using UPLC-MS\/MS","volume":"36","author":"Shah","year":"2022","journal-title":"Biomed. Chromatogr."},{"key":"2026091510083179800_cit11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.17159\/0379-4350\/2015\/V68A14","article-title":"Ultra performance liquid chromatography\ntandem mass spectrometric method development and validation for determination\nof neratinib in human plasma","volume":"68","author":"Wani","year":"2015","journal-title":"S. Afr. J. Chem."},{"key":"2026091510083179800_cit12","doi-asserted-by":"publisher","first-page":"101490","DOI":"10.1016\/j.rechem.2024.101490","article-title":"EGFR as therapeutic target to develop new generation\ntyrosine kinase inhibitors against breast cancer: A critical review","volume":"7","author":"Mariam Raju","year":"2024","journal-title":"Results Chem."},{"key":"2026091510083179800_cit13","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.3390\/s25072339","article-title":"Boron-Doped\nDiamond Electrodes for Toxins Sensing in\nEnvironmental Samples A Review","volume":"25","author":"Mijajlovic\u0301","year":"2025","journal-title":"Sensors"},{"key":"2026091510083179800_cit14","doi-asserted-by":"publisher","first-page":"181723","DOI":"10.1016\/j.jallcom.2025.181723","article-title":"Advances in boron-doped diamond electrodes: Fabrication,\nelectrochemical properties, and applications","volume":"1036","author":"Jaiswal","year":"2025","journal-title":"J. Alloys Compd."},{"key":"2026091510083179800_cit15","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1002\/celc.201801877","article-title":"Environmental Applications\nof Boron Doped Diamond Electrode: 2. Soil Remediation and Sensing\nApplications","volume":"6","author":"Trellu","year":"2019","journal-title":"ChemElectroChem"},{"key":"2026091510083179800_cit16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.diamond.2016.05.007","article-title":"Sensitive\ndetermination of anticancer drug imatinib in spiked human urine samples\nby differential pulse voltammetry on anodically pretreated boron-doped\ndiamond electrode","volume":"68","author":"Brycht","year":"2016","journal-title":"Diamond Relat. Mater."},{"key":"2026091510083179800_cit17","doi-asserted-by":"publisher","DOI":"10.1002\/elan.202400121","article-title":"Electrochemical determination of ibuprofen by batch-injection\nanalysis using a BORON-doped ultrananocrystalline diamond electrode","volume":"37","author":"Carolyne Prete","year":"2024","journal-title":"Electroanalysis"},{"key":"2026091510083179800_cit18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00706-022-03020-9","article-title":"Application of boron-doped diamond\nelectrode for rapid and sensitive voltammetric detection of vildagliptin\nin anionic surfactant medium","volume":"154","author":"Altunkaynak","year":"2023","journal-title":"Monatshefte fu\u0308r\nChemie - Chemical Monthly"},{"issue":"12","key":"2026091510083179800_cit19","doi-asserted-by":"publisher","first-page":"H780","DOI":"10.1149\/2.0671412jes","article-title":"Voltammetric Determination\nof an Antihypertensive Agent Phentolamine at BDDE in the Presence\nof Surfactants","volume":"161","author":"Satsangee","year":"2014","journal-title":"J. Electrochem. Soc."},{"issue":"1","key":"2026091510083179800_cit20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.cis.2005.09.004","article-title":"Beneficial\nrole of surfactants in\nelectrochemistry and in the modification of electrodes","volume":"119","author":"Vittal","year":"2006","journal-title":"Adv. Colloid Interface Sci."},{"issue":"17","key":"2026091510083179800_cit21","doi-asserted-by":"publisher","first-page":"5339","DOI":"10.3390\/molecules26175339","article-title":"A Surfactant Concentration Model\nfor the Systematic Determination\nof the Critical Micellar Concentration and the Transition Width","volume":"26","author":"Al-Soufi","year":"2021","journal-title":"Molecules"},{"issue":"21","key":"2026091510083179800_cit22","doi-asserted-by":"publisher","first-page":"5745","DOI":"10.1021\/acs.langmuir.0c00420","article-title":"Surfactant Self-Assembling\nand Critical Micelle Concentration: One\nApproach Fits All?","volume":"36","author":"Perinelli","year":"2020","journal-title":"Langmuir"},{"issue":"13\u201314","key":"2026091510083179800_cit23","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1002\/elps.8145","article-title":"Determination\nof Critical Micelle Concentration of\nIonic and Non-Ionic Surfactants by Streaming Potential Measurements","volume":"46","author":"Chenyakin","year":"2025","journal-title":"Electrophoresis"},{"key":"2026091510083179800_cit24","doi-asserted-by":"publisher","first-page":"124279","DOI":"10.1016\/j.molliq.2024.124279","article-title":"An investigation on\nthe hydrophobic binding stability of Azithromycin to the hydrocarbon\nchains of Tween: Based on micellization thermodynamics","volume":"398","author":"Liang","year":"2024","journal-title":"J. Mol. Liq."},{"key":"2026091510083179800_cit25","doi-asserted-by":"publisher","first-page":"461212","DOI":"10.1016\/j.chroma.2020.461212","article-title":"Understanding polysorbate-compound\ninteractions within the CMC region","volume":"1623","author":"Waters","year":"2020","journal-title":"J. Chromatogr.\nA"},{"key":"2026091510083179800_cit26","doi-asserted-by":"publisher","first-page":"114296","DOI":"10.1016\/j.jelechem.2020.114296","article-title":"A chemometric investigation on the\ninfluence of the nature and concentration of supporting electrolyte\non charging currents in electrochemistry","volume":"871","author":"Ahmadpour","year":"2020","journal-title":"J.\nElectroanal. Chem."},{"key":"2026091510083179800_cit27","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1080\/00032719.2024.2318653","article-title":"Voltammetric Determination\nof Metrafenone Using an Iridium Oxide Nanoparticle \u2013 Ionic\nLiquid Nanocomposite Modified Glassy Carbon Electrode","volume":"58","author":"Celik","year":"2024","journal-title":"Anal. Lett."},{"issue":"4","key":"2026091510083179800_cit28","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jpha.2017.03.002","article-title":"Electrochemical\ndetermination of an anti-hyperlipidimic\ndrug pitavastatin at electrochemical sensor based on electrochemically\npre-treated polymer film modified GCE","volume":"7","author":"Pandit","year":"2017","journal-title":"J. Pharm.\nAnal."},{"key":"2026091510083179800_cit29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jelechem.2018.09.006","article-title":"The effect\nof the supporting electrolyte\non the voltammetric determination of the veterinary drug nitroxinil","volume":"827","author":"Sipa","year":"2018","journal-title":"J. Electroanal. Chem."},{"key":"2026091510083179800_cit201","doi-asserted-by":"publisher","first-page":"D1265","DOI":"10.1093\/nar\/gkad976","article-title":"DrugBank\n6.0: the DrugBank Knowledgebase for 2024","volume":"52","author":"Knox","year":"2024","journal-title":"Nucleic\nAcids Res."},{"key":"2026091510083179800_cit30","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1002\/elan.200603840","article-title":"Electroanalytical\nDetermination of Lidocaine in Pharmaceutical Preparations Using Boron-Doped\nDiamond Electrodes","volume":"19","author":"Oliveira","year":"2007","journal-title":"Electroanalysis"},{"issue":"1","key":"2026091510083179800_cit31","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/S0022-0728(99)00478-7","article-title":"Electrochemical\nstudy of mefexamide\nat glassy-carbon electrodes and its determination in urine by differential\npulse voltammetry","volume":"481","author":"Bermejo","year":"2000","journal-title":"J. Electroanal. Chem."},{"key":"2026091510083179800_cit32","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/1521-4109(200201)14:2&lt;122::AID-ELAN122&gt;3.0.CO;2-1","article-title":"Electrochemical Behavior\nof Formoterol Fumarate and Its Determination in Capsules for Inhalation\nand Human Serum using Differential-Pulse and Square-Wave Voltammetry","volume":"14","author":"Demircigil","year":"2002","journal-title":"Electroanalysis"},{"issue":"2","key":"2026091510083179800_cit33","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0039-9140(03)00248-0","article-title":"Voltammetric\ninvestigation of Tamsulosin","volume":"61","author":"Ozkan","year":"2003","journal-title":"Talanta"},{"key":"2026091510083179800_cit34","doi-asserted-by":"publisher","first-page":"097501","DOI":"10.1149\/1945-7111\/adfeeb","article-title":"In Silico, Electrochemical,\nand Spectroscopic Approaches on the Interaction of Nabumetone with\nDouble-Stranded DNA","volume":"172","author":"Khan","year":"2025","journal-title":"J. Electrochem. Soc."},{"key":"2026091510083179800_cit35","doi-asserted-by":"publisher","first-page":"117651","DOI":"10.1016\/j.jelechem.2023.117651","article-title":"Decoration of Bi2O3NPs-AgNPs-ErGO\nas a first electrochemical nanosensor\nfor sensitive determination of nelarabine in pharmaceutical dosage\nform and human serum samples","volume":"944","author":"Kabir","year":"2023","journal-title":"J. Electroanal.\nChem."},{"key":"2026091510083179800_cit200","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1080\/00032710701298453","article-title":"Electroanalytical\ncharacterization of verapamil and its voltammetric determination in\npharmaceuticals and human serum","volume":"40","author":"Demircan","year":"2007","journal-title":"Analytical\nLetters"},{"issue":"1","key":"2026091510083179800_cit36","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s44371-025-00231-x","article-title":"Green metric-based RP-HPLC method development and validation\nwith force degradation study of neratinib using QbD approach","volume":"2","author":"Sawant","year":"2025","journal-title":"Discover Chemistry"},{"issue":"14","key":"2026091510083179800_cit37","doi-asserted-by":"publisher","first-page":"10076","DOI":"10.1021\/acs.analchem.0c01887","article-title":"AGREE& #xe5f8;Analytical GREEnness\nMetric Approach and Software","volume":"92","author":"Pena-Pereira","year":"2020","journal-title":"Anal. Chem."},{"key":"2026091510083179800_cit38","doi-asserted-by":"publisher","first-page":"116553","DOI":"10.1016\/j.trac.2022.116553","article-title":"AGREEprep\n\u2013 Analytical Greenness Metric for Sample Preparation","volume":"149","author":"Wojnowski","year":"2022","journal-title":"TrAC, Trends Anal. Chem."},{"key":"2026091510083179800_cit39","doi-asserted-by":"publisher","first-page":"100126","DOI":"10.1016\/j.greeac.2024.100126","article-title":"A total scoring\nsystem\nand software for complex modified GAPI (ComplexMoGAPI) application\nin the assessment of method greenness","volume":"10","author":"Mansour","year":"2024","journal-title":"Green\nAnal. Chem"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c05232","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/36\/54221\/68145008\/acsomega.6c05232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/36\/54221\/68145008\/acsomega.6c05232.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:43:06Z","timestamp":1789483386000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/36\/54221\/5399912\/Electrochemical-Behavior-of-Neratinib-at-a-Boron"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":41,"journal-issue":{"issue":"36","published-online":{"date-parts":[[2026,9,1]]},"published-print":{"date-parts":[[2026,9,15]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c05232","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}