{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:45:12Z","timestamp":1791924312761,"version":"4.3.4"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003758","name":"Funda??o de Amparo ? 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The formulation showed high apparent active-material recovery after centrifugation and filtration, as estimated by HPLC-PDA. DLS analysis indicated a polydisperse colloidal profile, with an apparent mean hydrodynamic diameter of approximately 406.5 nm and a number-weighted smaller population centered at approximately 12.1 nm. FTIR data were consistent with formulation-related changes in the vibrational environment of the hydrophobic active materials, while AFM and SEM provided complementary morphological information on deposited or dried samples. Together, these data support an interpretative F127-based self-assembly model, without establishing a fully uniform colloidal population or a definitively resolved internal micellar architecture. In vitro cytotoxicity assays using GM07492A human lung fibroblasts indicated low basal cytotoxicity under dark conditions, whereas light exposure produced concentration-dependent viability reductions at higher formulation concentrations. Antileishmanial assays against Leishmania amazonensis promastigotes revealed a marked light-associated response, mainly in formulations containing the brachydin-enriched fraction. FB showed the highest potency under light exposure, with a formulation-based IC50 of 18.63 \u03bcg mL\u20131, whereas FBC showed an IC50 decrease from 72.74 to 34.33 \u03bcg mL\u20131. Thus, although FBC was not more potent than FB, it combined light-associated antileishmanial activity, high apparent active-material recovery, and favorable macroscopic formulation behavior. Because FB and FBC contain a brachydin-enriched fraction rather than purified individual brachydins, the biological responses should be interpreted as preliminary formulation-level effects. Further studies involving direct reactive oxygen species measurements, intracellular amastigote assays, formal selectivity analysis, fraction standardization, and long-term colloidal stability evaluation are still required before therapeutic efficacy can be inferred.<\/jats:p>","DOI":"10.1021\/acsomega.6c05278","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:01:42Z","timestamp":1790870502000},"page":"61032-61051","source":"Crossref","is-referenced-by-count":0,"title":["Pluronic F127 Micelles\nCo-encapsulating a Brachydin-Enriched\nFraction and Curcumin: A Self-assembled Platform for Light-assisted\nAntileishmanial Activity"],"prefix":"10.1021","volume":"11","author":[{"given":"Ingrid Maria Ribeiro","family":"de Lima","sequence":"first","affiliation":[{"name":"Federal University of Maranha\u0303o , , ,","place":["Sa\u0303o Lui\u0301s, Brazil, 65080-805"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Santana","family":"Figueredo","sequence":"additional","affiliation":[{"name":"Federal University of Maranha\u0303o , , ,","place":["Sa\u0303o Lui\u0301s, Brazil, 65080-805"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucilene Amorim","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Maranha\u0303o , , ,","place":["Sa\u0303o Lui\u0301s, Brazil, 65080-805"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8210-2016","authenticated-orcid":true,"given":"Luciana Magalha\u0303es Rebelo","family":"Alencar","sequence":"additional","affiliation":[{"name":"Federal University of Maranha\u0303o , , ,","place":["Sa\u0303o Lui\u0301s, Brazil, 65080-805"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3578-1869","authenticated-orcid":true,"given":"Cla\u0301udia Quintino","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Federal University of Maranha\u0303o , , ,","place":["Sa\u0303o Lui\u0301s, Brazil, 65080-805"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2701-6101","authenticated-orcid":true,"given":"Renato Sonchini","family":"Gonc\u0327alves","sequence":"additional","affiliation":[{"name":"Federal University of Parana\u0301 (UFPR) , , , ,","place":["Palotina, Parana, Brazil, 85950-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026101315092301700_cit1","unstructured":"World Health Organization.\n          \n          Global leishmaniasis surveillance: 2021\u20132022,\nassessing the impact of the covid-19 pandemic; World Health Organization, 2023; Technical\nReport 41."},{"issue":"8","key":"2026101315092301700_cit2","first-page":"1076","article-title":"Global,\nregional, and national burden of leishmaniasis, 1990\u20132019:\na systematic analysis for the global burden of disease study 2019","volume":"21","author":"Zheng","year":"2021","journal-title":"Lancet Infect. Dis."},{"issue":"10151","key":"2026101315092301700_cit3","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0140-6736(18)31204-2","article-title":"Croft, and Marleen\nBoelaert. Leishmaniasis","volume":"392","author":"Burza","year":"2018","journal-title":"Lancet"},{"issue":"3","key":"2026101315092301700_cit4","first-page":"51","article-title":"Recent developments\nand future prospects in the treatment of leishmaniasis","volume":"5","author":"Sundar","year":"2018","journal-title":"Ther. Adv. Infect. Dis."},{"key":"2026101315092301700_cit5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2147\/dddt.s146521","article-title":"Leishmaniasis in humans: drug or vaccine therapy?","volume":"12","author":"Ghorbani","year":"2017","journal-title":"Drug Des. Devel. Ther."},{"key":"2026101315092301700_cit6","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4899-2911-2","volume-title":"The flavonoids: advances\nin research since 1986","author":"Harborne","year":"1994"},{"key":"2026101315092301700_cit7","article-title":"Antileishmanial\nactivity of natural products and flavonoids","author":"Peixoto","year":"2019","journal-title":"J. Nat. Prod."},{"issue":"6","key":"2026101315092301700_cit8","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1021\/np401060j","article-title":"Dimeric\nFlavonoids from Arrabidaea brachypoda and Assessment of Their Anti-Trypanosoma\ncruzi Activity","volume":"77","author":"Rocha","year":"2014","journal-title":"J. Nat. 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