{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:07:05Z","timestamp":1788876425902,"version":"build-2803163510"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00335266"],"award-info":[{"award-number":["RS-2024-00335266"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To fundamentally address the limited tissue penetration of conventional fluorescence-based imaging, X-ray attenuation\u2013based imaging approaches have been proposed. In this study, mesoporous tin oxide (SnO2) nanoparticles (NPs) with a diameter of approximately 70 nm were synthesized and functionalized with PAp7T8 and HER2apt28 aptamers, which target pancreatic and breast cancer cells, respectively. The synthesized SnO2 NPs exhibit greater X-ray attenuation than any of the tested metal oxide NPs in the tens of keV energy range corresponding to plain X-ray imaging. The surface-conjugated aptamers enable selective binding of the NPs to cancer cells, leading to efficient cellular uptake and internalization. In a model X-ray imaging experiment, as little as 5 mg of the SnO2 NPs placed beneath 3 cm-thick biological tissues is distinctly identified with high contrast. Overall, the excellent X-ray attenuation capabilities and target specificity of these aptamer-conjugated SnO2 NPs demonstrate their significant potential as a nanoplatform for the noninvasive imaging and diagnosis of deep-seated cancers.<\/jats:p>","DOI":"10.1021\/acsomega.6c05392","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:00:51Z","timestamp":1788177651000},"page":"53040-53049","source":"Crossref","is-referenced-by-count":0,"title":["Aptamer-Conjugated\nTin Oxide Nanoparticles for Noninvasive\nDetection of Cancer"],"prefix":"10.1021","volume":"11","author":[{"given":"Haneul","family":"Shin","sequence":"first","affiliation":[{"name":"Kookmin University , , ,","place":["Seoul, South Korea, 02707"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yul Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Kookmin University , , ,","place":["Seoul, South Korea, 02707"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungho","family":"Lee","sequence":"additional","affiliation":[{"name":"Kookmin University , , ,","place":["Seoul, South Korea, 02707"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dain","family":"Kim","sequence":"additional","affiliation":[{"name":"Kookmin University , , ,","place":["Seoul, South Korea, 02707"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6296-2625","authenticated-orcid":true,"given":"Nohyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Kookmin University , , ,","place":["Seoul, South Korea, 02707"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyun","family":"Heo","sequence":"additional","affiliation":[{"name":"Kookmin University , , ,","place":["Seoul, South Korea, 02707"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1322-2713","authenticated-orcid":true,"given":"Sanggyu","family":"Yim","sequence":"additional","affiliation":[{"name":"Kookmin University , , ,","place":["Seoul, South Korea, 02707"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"2026090809084902300_cit1","doi-asserted-by":"publisher","first-page":"1706356","DOI":"10.1002\/adma.201706356","article-title":"Biocompatible\nSemiconductor Quantum Dots as Cancer Imaging Agents","volume":"30","author":"McHugh","year":"2018","journal-title":"Adv. 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