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The glasses were synthesized by melt-quenching technique and characterized by density, molar volume, FTIR, N4, XRD, radiopacity, in vitro test in SBF, mass loss, SEM-EDS cellular viability, cell migration assay, and antibacterial activity. The volumetric density and N4 increased, and the molar volume decreased, indicating that the addition of ZnO changed the structure of the materials. DTA analysis showed that Tg did not vary significantly, Tx increased due to the ZnO addition, and all samples presented good thermal stability. The radiopacity level of the glass samples was enhanced with ZnO addition. Also, analyses of mass loss and pH measurements shown an increase in the chemical stability of samples with ZnO contents. After immersion in SBF, the XRD diffractograms and FTIR spectra of glasses indicated the bioactivity of the CaNaB, 2.5% ZnO, and 5% ZnO samples by the presence of peaks and bands characteristic of HA formation. By cell viability analysis using RAW-264.7 murine macrophages, all glasses were shown to be noncytotoxic. Bioactive glasses compositions preserve the intrinsic migratory capacity of human fibroblasts. All glass samples showed antibacterial activity against Gram-positive and Gram-negative bacteria. The results indicate the potential of glass samples for bone tissue regeneration.<\/jats:p>","DOI":"10.1021\/acsomega.6c05452","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T14:01:37Z","timestamp":1786888897000},"page":"51553-51567","source":"Crossref","is-referenced-by-count":0,"title":["Influence of ZnO\nAddition on the Structural and Biological\nProperties of Borate Bioactive Glasses for Bone Tissue Regeneration"],"prefix":"10.1021","volume":"11","author":[{"given":"Tai\u0301s Silva","family":"Morais","sequence":"first","affiliation":[{"name":"Universidade Federal do Maranha\u0303o , , , ,","place":["Imperatriz, MA, Brazil, 65915-240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ota\u0301vio Ca\u0302ndido da","family":"Silva Neto","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranha\u0303o , , , ,","place":["Imperatriz, MA, Brazil, 65915-240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Nayane de","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranha\u0303o , , , ,","place":["Imperatriz, MA, Brazil, 65915-240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatielle Gomes","family":"Dias","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranha\u0303o , , , ,","place":["Imperatriz, MA, Brazil, 65915-240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Liberalino","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio Grande do Norte\u2500UERN , , , ,","place":["Mossoro\u0301, RN, Brazil, 59607-360"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria Raquel Queiroz","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio Grande do Norte\u2500UERN , , , ,","place":["Mossoro\u0301, RN, Brazil, 59607-360"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Mesquita Basto","family":"Maia","sequence":"additional","affiliation":[{"name":"Universidade Ceuma , Campus Imperatriz, Rua Bara\u0303o do Rio Branco, n\u00b0 100 , , ,","place":["Imperatriz, Ma, Brazil, 65903-093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aramys Silva","family":"Reis","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranha\u0303o , , , ,","place":["Imperatriz, MA, Brazil, 65915-240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Pereira","family":"Dutra","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranha\u0303o , , , ,","place":["Imperatriz, MA, Brazil, 65915-240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thales Allyrio Arau\u0301jo de Medeiros","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio Grande do Norte\u2500UERN , , , ,","place":["Mossoro\u0301, RN, Brazil, 59607-360"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alysson","family":"Steimacher","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranha\u0303o , , , ,","place":["Imperatriz, MA, Brazil, 65915-240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-9753","authenticated-orcid":true,"given":"Franciana","family":"Pedrochi","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranha\u0303o , , , ,","place":["Imperatriz, MA, Brazil, 65915-240"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"key":"2026090307185331100_cit1","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.biomaterials.2015.02.112","article-title":"Wound dressings\ncomposed of copper-doped borate bioactive glass microfibers stimulate\nangiogenesis and heal full-thickness skin defects in a rodent model","volume":"53","author":"Zhao","year":"2015","journal-title":"Biomaterials"},{"key":"2026090307185331100_cit2","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.jallcom.2018.01.099","article-title":"Fabrication\nand characterization of strontium-doped\nborate-based bioactive glass scaffolds for bone tissue engineering","volume":"743","author":"Yin","year":"2018","journal-title":"J. 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