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Physicochemical characterization showed improved thermal stability, tunable hydrophilicity, and a porous network suitable for loading and release. In vitro release studies demonstrated sustained cannabinoid delivery over 72 h, following first-order and Fu\u2013Kao kinetic models. The hydrogels exhibited selective antimicrobial activity against Staphylococcus aureus, while remaining inactive toward Escherichia coli. Cytocompatibility assays with human skin fibroblasts confirmed noncytotoxic behavior over 7 days for all hydrogel formulations tested. These results highlight that cyclodextrin\u2013cannabinoid-loaded agar\/xanthan hydrogels are promising biocompatible platforms for controlled delivery with antimicrobial activity, suitable for tissue engineering applications.<\/jats:p>","DOI":"10.1021\/acsomega.6c05484","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:07:52Z","timestamp":1785128872000},"page":"46955-46971","source":"Crossref","is-referenced-by-count":2,"title":["Biocompatible Cyclodextrin\u2013Cannabinoid\nAgar\u2013Xanthan\nGum Hydrogels for Controlled Delivery and Antimicrobial Soft-Tissue\nBiomedical Applications"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8704-1539","authenticated-orcid":true,"given":"Camilo","family":"Zamora-Ledezma","sequence":"first","affiliation":[{"name":"Universidad Alfonso X el Sabio (UAX) , . 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