{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:07:38Z","timestamp":1790698058886,"version":"4.1.0"},"reference-count":67,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ferroptosis-induced renal fibrosis is a key driver of chronic kidney disease (CKD) progression, yet effective therapies remain limited. This study investigates the therapeutic potential of quercetin (QCT), a bioflavonoid derived from Ginkgo biloba fruit peel, in mitigating ferroptosis-associated renal fibrosis. Network pharmacology identified HMOX1 and PTGS2 as core candidate genes associated with the therapeutic response to QCT in renal fibrosis. In a unilateral ureteral obstruction (UUO)-induced CKD mouse model, QCT treatment attenuated tubular injury, improved renal function, and reduced fibrosis markers such as fibronectin, Col1a1, and \u03b1-SMA. Mechanistically, QCT suppressed ferroptosis and epithelial\u2013mesenchymal transition (EMT) by downregulating HMOX1. Further analysis revealed that PRDM9, a histone methyltransferase and transcription factor, drives HMOX1 expression through both transcriptional activation and H3K4me3-mediated epigenetic modification. Knockdown of PRDM9 reduced HMOX1 expression and alleviated fibrosis. These findings highlight a novel epigenetic mechanism underlying ferroptosis-induced renal fibrosis and position QCT as a promising therapeutic candidate for CKD.<\/jats:p>","DOI":"10.1021\/acsomega.6c05732","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:01:55Z","timestamp":1789556515000},"page":"57378-57393","source":"Crossref","is-referenced-by-count":0,"title":["Quercetin Alleviates\nFerroptosis-Induced Renal Fibrosis\nby Modulating the PRDM9\/HMOX1\/PTGS2 Axis"],"prefix":"10.1021","volume":"11","author":[{"given":"Qiongqiong","family":"Zhu","sequence":"first","affiliation":[{"name":"Yueqing Hospital of Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, Peoples R China, 325600"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Chen","sequence":"additional","affiliation":[{"name":"Yueqing Hospital of Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, Peoples R China, 325600"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxian","family":"Yu","sequence":"additional","affiliation":[{"name":"Yueqing Hospital of Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, Peoples R China, 325600"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Ye","sequence":"additional","affiliation":[{"name":"Yueqing Hospital of Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, Peoples R China, 325600"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9597-7253","authenticated-orcid":true,"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"Yueqing Hospital of Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, Peoples R China, 325600"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"10523","key":"2026092911084952000_cit1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/S0140-6736(25)01942-7","article-title":"Chronic kidney disease","volume":"407","author":"Herrington","year":"2026","journal-title":"Lancet"},{"key":"2026092911084952000_cit2","doi-asserted-by":"publisher","first-page":"113947","DOI":"10.1016\/j.biopha.2022.113947","article-title":"Empagliflozin reduces kidney fibrosis and improves\nkidney function by alternative macrophage activation in rats with\n5\/6-nephrectomy","volume":"156","author":"Lu","year":"2022","journal-title":"Biomed. 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