{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:08:39Z","timestamp":1790698119914,"version":"4.1.0"},"reference-count":33,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008279","name":"Ludong University","doi-asserted-by":"publisher","award":["ly2014041"],"award-info":[{"award-number":["ly2014041"]}],"id":[{"id":"10.13039\/501100008279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MC116"],"award-info":[{"award-number":["ZR2022MC116"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong provincial education system government sponsored study abroad program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As a highly hazardous heavy metal, mercury ion (Hg2+) poses a serious threat to human health through the intake of polluted aquatic products and water. Accordingly, the development of a simple, sensitive, and efficient method for Hg2+ detection is of significant importance. Herein, a novel silver nanoparticle (Qu-CD-AgNPs) was successfully synthesized using an inclusion complex of Qu and \u03b2-cyclodextrin, which forms an Ag\u2013Hg alloy upon interaction with Hg2+, markedly enhancing its oxidase-like activity to oxidize 3,3\u2032,5,5\u2032-tetramethylbenzidine (TMB), generating a Hg2+ concentration-dependent color change. On this basis, a colorimetric detection platform for Hg2+ was fabricated by integrating the hydrogel-based Qu-CD-AgNPs + TMB system and a self-developed RGB-values-analysis app for portable equipment. Under the optimized conditions, the platform shows a linear range between 3 and 100 \u03bcM and a detection limit as low as 0.023 \u03bcM, as well as excellent selectivity and anti-interference performance. This work promises a broad application prospect in water-quality monitoring and the inspection of aquatic products.<\/jats:p>","DOI":"10.1021\/acsomega.6c05867","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:01:56Z","timestamp":1789542116000},"page":"57656-57664","source":"Crossref","is-referenced-by-count":0,"title":["Portable-Equipment-Assisted\nColorimetric Hydrogel\nKits Based on Quercetin-Reducing Silver Nanoparticles for Hg2+ Tests in Aquatic Products"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9738-5438","authenticated-orcid":true,"given":"Qinghao","family":"Ge","sequence":"first","affiliation":[{"name":"Ludong University , , No. 186, Hongqi Middle Road, Zhifu District , ,","place":["Yantai, China, 264025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzhuo","family":"Zheng","sequence":"additional","affiliation":[{"name":"Ludong University , , No. 186, Hongqi Middle Road, Zhifu District , ,","place":["Yantai, China, 264025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Hou","sequence":"additional","affiliation":[{"name":"Ludong University , , No. 186, Hongqi Middle Road, Zhifu District , ,","place":["Yantai, China, 264025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Ludong University , , No. 186, Hongqi Middle Road, Zhifu District , ,","place":["Yantai, China, 264025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Ludong University , , No. 186, Hongqi Middle Road, Zhifu District , ,","place":["Yantai, China, 264025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Han","sequence":"additional","affiliation":[{"name":"Jining University , , No. 1 Xingtan Road, New District , ,","place":["Qufu, China, 273155"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Ding","sequence":"additional","affiliation":[{"name":"Ludong University , , No. 186, Hongqi Middle Road, Zhifu District , ,","place":["Yantai, China, 264025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2213-8329","authenticated-orcid":true,"given":"Yang","family":"Pu","sequence":"additional","affiliation":[{"name":"Ludong University , , No. 186, Hongqi Middle Road, Zhifu District , ,","place":["Yantai, China, 264025"]},{"name":"Ludong University , , No. 186, Hongqi Middle Road, Zhifu District , ,","place":["Yantai, China, 264025"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"2026092911121312600_cit1","doi-asserted-by":"publisher","first-page":"111442","DOI":"10.1016\/j.jenvman.2020.111442","article-title":"Status and Environmental\nManagement of Soil Mercury Pollution in China: A review","volume":"277","author":"Liu","year":"2021","journal-title":"J. Environ. Manage."},{"issue":"1","key":"2026092911121312600_cit2","doi-asserted-by":"publisher","first-page":"460508","DOI":"10.1155\/2012\/460508","article-title":"Mercury\nToxicity and Treatment: a Review of the Literature","volume":"2012","author":"Bernhoft","year":"2012","journal-title":"J. Environ. Public Health"},{"key":"2026092911121312600_cit3","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.talanta.2012.07.052","article-title":"A Stable and Reproducible Nanosilver-Aggregation-4-Mercaptopyridine\nSurface-Enhanced Raman Scattering Probe for Rapid Determination of\nTrace Hg2+","volume":"99","author":"Li","year":"2012","journal-title":"Talanta"},{"key":"2026092911121312600_cit4","doi-asserted-by":"publisher","first-page":"214363","DOI":"10.1016\/j.ccr.2021.214363","article-title":"Silver Nanomaterials\nSensing of Mercury Ions in Aqueous Medium","volume":"456","author":"Lu","year":"2022","journal-title":"Coord.\nChem. Rev."},{"issue":"14","key":"2026092911121312600_cit5","doi-asserted-by":"publisher","first-page":"13062","DOI":"10.1021\/acsnano.3c04378","article-title":"Rational Design Strategies for Nanozymes","volume":"17","author":"Chen","year":"2023","journal-title":"ACS\nNano"},{"issue":"4","key":"2026092911121312600_cit6","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1007\/s00216-023-05090-y","article-title":"Portable Smartphone-Assisted\nHighly Sensitive Detection of Mercury Ions Based on Gold Nanoparticle-Modified\nNH2-UiO-66 Metal-Organic Framework","volume":"416","author":"Wang","year":"2024","journal-title":"Anal. Bioanal. Chem."},{"issue":"3","key":"2026092911121312600_cit7","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1039\/D5AN01167A","article-title":"A Portable Smartphone\nAssisted Multi-Color Colorimetric Sensor for the Detection of Mercury\nIons Based on the Peroxidase-Like Activity of Platinum Nanoparticles","volume":"151","author":"Wang","year":"2026","journal-title":"Analyst"},{"issue":"9","key":"2026092911121312600_cit8","doi-asserted-by":"publisher","first-page":"358","DOI":"10.3390\/chemosensors10090358","article-title":"Sustainable PVP-Capped Silver Nanoparticles\nas a Free-Standing Nanozyme Sensor for Visual and Spectrophotometric\nDetection of Hg2+ in Water Samples: A Green Analytical\nMethod","volume":"10","author":"Abdel-Lateef","year":"2022","journal-title":"Chemosensors"},{"issue":"2","key":"2026092911121312600_cit9","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.jksus.2019.10.015","article-title":"A Highly Sensitive\nColorimetric Sensor\nfor Hg2+ Detection Based on the Oxidative Enzyme Mimics-Like\nActivity of Hierarchical Porous Carbon@Chitosan-Modified Silver Nanoparticles","volume":"32","author":"Zhang","year":"2020","journal-title":"King. Saud. Univ. Sci."},{"issue":"1","key":"2026092911121312600_cit10","doi-asserted-by":"publisher","first-page":"6953","DOI":"10.1038\/s41598-022-10779-8","article-title":"Utilization\nof The Peroxidase-Like Activity of Silver Nanoparticles Nanozyme on\nO-phenylenediamine\/H2O2 System for Fluorescence\nDetection of Mercury (II) Ions","volume":"12","author":"Abdel-Lateef","year":"2022","journal-title":"Sci. Rep."},{"issue":"8","key":"2026092911121312600_cit11","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1007\/s00604-023-05921-w","article-title":"Silver Nanoparticles\nDeposited Carbon Microspheres Nanozyme with\nEnhanced Peroxidase-Like Catalysis for Colorimetric Detection of Hg2+in Seafood","volume":"190","author":"Zhang","year":"2023","journal-title":"Mikrochim. Acta"},{"issue":"9","key":"2026092911121312600_cit12","doi-asserted-by":"publisher","first-page":"4335","DOI":"10.1021\/acs.analchem.2c04548","article-title":"Ag Aerogel-Supported\nSingle-Atom Hg Nanozyme Enables Efficient Sers Monitoring of Enhanced\nOxidase-like Catalysis","volume":"95","author":"Liu","year":"2023","journal-title":"Anal. Chem."},{"issue":"2","key":"2026092911121312600_cit13","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.nanoms.2022.10.002","article-title":"Double Enzyme\nMimetic Activities of Multifunctional Ag Nanoparticle-Decorated\nCo3V2O8 Hollow Hexagonal Prismatic\nPencils for Application in Colorimetric Sensors and Disinfection","volume":"6","author":"Gao","year":"2024","journal-title":"Nano Mater. Sci."},{"key":"2026092911121312600_cit14","doi-asserted-by":"publisher","first-page":"111748","DOI":"10.1016\/j.microc.2024.111748","article-title":"Nanozymes in Environmental Remediation:\nA Bibliometric\nand Comprehensive Review of Their Oxidoreductase-Mimicking Capabilities","volume":"207","author":"Nagendran","year":"2024","journal-title":"Microchem. J."},{"issue":"20","key":"2026092911121312600_cit15","doi-asserted-by":"publisher","first-page":"8996","DOI":"10.7150\/thno.45413","article-title":"Silver Nanoparticles:\nSynthesis, Medical Applications and Biosafety","volume":"10","author":"Xu","year":"2020","journal-title":"Theranostics"},{"issue":"6","key":"2026092911121312600_cit16","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.3390\/molecules24061123","article-title":"Antioxidant Activities\nof Quercetin and Its Complexes for Medicinal Application","volume":"24","author":"Xu","year":"2019","journal-title":"Molecules"},{"key":"2026092911121312600_cit17","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bioactmat.2024.09.012","article-title":"Silver-quercetin-loaded Honeycomb-Like\nTi-Based Interface Combats Infection-Triggered Excessive Inflammation\nvia Specific Bactericidal and Macrophage Reprogramming","volume":"43","author":"Yang","year":"2025","journal-title":"Bioact. Mater."},{"issue":"12","key":"2026092911121312600_cit18","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.3390\/mi14122154","article-title":"Synthesis of Quercetin-Loaded\nSilver Nanoparticles\nand Assessing Their Anti-Bacterial Potential","volume":"14","author":"Sharma","year":"2023","journal-title":"Micromachines"},{"issue":"23","key":"2026092911121312600_cit19","doi-asserted-by":"publisher","first-page":"8140","DOI":"10.1007\/s10853-014-8523-6","article-title":"Fabrication\nof Cyclodextrin Nanosponges for Quercetin\nDelivery: Physicochemical Characterization, Photostability, and Antioxidant\nEffects","volume":"49","author":"Anandam","year":"2014","journal-title":"J. Mater. Sci."},{"issue":"12","key":"2026092911121312600_cit20","doi-asserted-by":"publisher","first-page":"13807","DOI":"10.1021\/acsanm.1c03189","article-title":"Ag-\u03b2-Cyclodextrin-Graphene\nOxide Ternary Nanostructures with Peroxidase-Mimicking Activity for\nHg2+ Detection","volume":"4","author":"Xing","year":"2021","journal-title":"ACS Appl. Nano Mater."},{"issue":"9","key":"2026092911121312600_cit21","doi-asserted-by":"publisher","first-page":"3538","DOI":"10.3390\/ma16093538","article-title":"Beta-Cyclodextrin\nNanosponges Inclusion Compounds Associated with Silver Nanoparticles\nto Increase the Antimicrobial Activity of Quercetin","volume":"16","author":"Salazar Sandoval","year":"2023","journal-title":"Materials"},{"key":"2026092911121312600_cit22","doi-asserted-by":"publisher","first-page":"215209","DOI":"10.1016\/j.ccr.2023.215209","article-title":"Applications of Single-Site\nIron Nanozymes in Biomedicine","volume":"490","author":"Han","year":"2023","journal-title":"Coord. Chem.\nRev."},{"issue":"9","key":"2026092911121312600_cit23","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nnano.2007.260","article-title":"Intrinsic\nPeroxidase-Like Activity of Ferromagnetic Nanoparticles","volume":"2","author":"Gao","year":"2007","journal-title":"Nat. Nanotechnol."},{"issue":"17","key":"2026092911121312600_cit24","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1021\/acs.accounts.3c00339","article-title":"Catalytic Signal Transduction Theory\nEnabled Virtual Screening of Nanomaterials for Medical Functions","volume":"56","author":"Gao","year":"2023","journal-title":"Acc. Chem. Res."},{"issue":"4","key":"2026092911121312600_cit25","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1021\/acssensors.2c02054","article-title":"Quercetin-mediated\nSilver Nanoparticle\nFormation for the Colorimetric Detection of Infectious Pathogens Coupled\nwith Loop-Mediated Isothermal Amplification","volume":"8","author":"Sivakumar","year":"2023","journal-title":"ACS Sens."},{"issue":"1","key":"2026092911121312600_cit26","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1021\/acs.analchem.9b05222","article-title":"A Heparinase\nSensor Based on a Ternary System of Hg2+-heparin-osmium\nNanoparticles","volume":"92","author":"He","year":"2020","journal-title":"Anal. Chem."},{"key":"2026092911121312600_cit27","doi-asserted-by":"publisher","first-page":"106882","DOI":"10.1016\/j.jece.2021.106882","article-title":"Highly sensitive B,\nN Co-doped Carbon\nDots for Fluorescent and Colorimetric Dual-Mode Detection of Mercury\nIons in Wastewater","volume":"9","author":"Fu","year":"2021","journal-title":"J. Environ. Chem. Eng."},{"key":"2026092911121312600_cit28","doi-asserted-by":"publisher","first-page":"104691","DOI":"10.1016\/j.algal.2026.104691","article-title":"A Powdery Biohybrid Nano-silver Sensor Based on Phycoerythrin\nand\nCarbon Nanotubes for Visual Detection of Hg2+ in Aquatic\nProducts","volume":"96","author":"Liu","year":"2026","journal-title":"Algal Res."},{"issue":"10","key":"2026092911121312600_cit29","doi-asserted-by":"publisher","first-page":"13761","DOI":"10.1021\/acsanm.2c00834","article-title":"Quercetagetin-stabilized Silver Nanoparticles for the\nOxidation of Morin","volume":"5","author":"Bulut","year":"2022","journal-title":"ACS Appl. Nano Mater."},{"issue":"1","key":"2026092911121312600_cit30","doi-asserted-by":"publisher","first-page":"11892","DOI":"10.1038\/s41598-025-96684-2","article-title":"Enhanced Urease\nInhibitory Activity of Quercetin via Conjugation with Silver Nanoparticles:\nSynthesis, Characterization, and DFT Study","volume":"15","author":"Asadi","year":"2025","journal-title":"Sci. Rep."},{"key":"2026092911121312600_cit31","doi-asserted-by":"publisher","first-page":"148973","DOI":"10.1016\/j.apsusc.2021.148973","article-title":"Hg2+-activated Oxidase-like\nActivity of Ag2S@graphene Oxide Nanozyme and Its Naked-eye\nMonitoring Hg2+ Application with Obvious Hyperchromic Effect","volume":"545","author":"Zhao","year":"2021","journal-title":"Appl. Surf. Sci."},{"issue":"22","key":"2026092911121312600_cit32","doi-asserted-by":"publisher","first-page":"6611","DOI":"10.1007\/s00216-022-04222-0","article-title":"Ag Nanozyme Strengthened by Folic\nAcid: Superior Peroxidase-Mimicking Activity and Application for Visual\nMonitoring of Dopamine","volume":"414","author":"Tang","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"2026092911121312600_cit33","doi-asserted-by":"publisher","first-page":"136200","DOI":"10.1016\/j.snb.2024.136200","article-title":"Cu@MOF Core-Shell\nAerogel: High Enzyme-Like\nActivity for Ultratrace Colorimetric Detection of Hg2+ Ions","volume":"417","author":"Li","year":"2024","journal-title":"Sensor. Actuator. B Chem."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c05867","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/38\/57656\/68526245\/acsomega.6c05867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/38\/57656\/68526245\/acsomega.6c05867.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:50:27Z","timestamp":1790697027000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/38\/57656\/5430934\/Portable-Equipment-Assisted-Colorimetric-Hydrogel"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":33,"journal-issue":{"issue":"38","published-online":{"date-parts":[[2026,9,16]]},"published-print":{"date-parts":[[2026,9,29]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c05867","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]}}}