{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:10:20Z","timestamp":1790698220928,"version":"4.1.0"},"reference-count":67,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f?r Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["FKZ:03Z22HN11"],"award-info":[{"award-number":["FKZ:03Z22HN11"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030902","name":"Martin-Luther-Universit?t Halle-Wittenberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030902","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metal-organic frameworks (MOFs) offer modular platforms for cancer nanomedicine, but how metal precursor chemistry and linker functionalization jointly regulate physicochemical properties and biological response remains insufficiently defined. Here, three Fe-based MOFs, Fe-BDC-1, Fe-BDC-2, and Fe-NH2-BDC, were synthesized by solvothermal routes using BDC or NH2-BDC linkers and Fe nitrate or Fe chloride precursors. XRD, FTIR, SEM, magnetic measurements, UV\u2013Vis diffuse reflectance, and photoluminescence analyses showed that Fe-BDC-1 and Fe-BDC-2 form closely related Fe-BDC frameworks, with FeCl3 promoting higher crystallinity and distinct particle assembly, whereas amino functionalization yields a structurally and optically distinct Fe-NH2-BDC phase with broadened visible-light absorption, lower band-gap energy, and enhanced emission. Biological activity was assessed in PC-3 prostate cancer cells and PNT1A normal prostate epithelial cells using WST-1 assays under magnet-free and magnet-exposed conditions, followed by DOX-combination testing and Annexin V\/PI flow cytometry. Fe-BDC-2 displayed pronounced intrinsic toxicity toward PC-3 cells, including near-complete viability loss at 150 \u03bcg\/mL after 48 h, while PNT1A cells showed comparatively lower sensitivity under selected conditions. Magnetic exposure further amplified cytotoxicity, particularly at higher doses and prolonged exposure. In WST-1 assays, Fe-NH2-BDC co-treatment with DOX produced the most consistent reduction in PC-3 metabolic viability under selected conditions. However, Annexin V\/PI analysis did not indicate enhanced apoptosis and instead revealed predominantly PI-positive membrane damage with mixed cell-death features. Magnetic exposure further amplified cytotoxicity, particularly at higher doses and prolonged exposure. In WST-1 assays, Fe-NH2-BDC co-treatment with DOXorubicin (DOX) produced the most consistent reduction in PC-3 metabolic viability under selected conditions. However, Annexin V\/PI analysis did not indicate enhanced apoptosis and instead revealed predominantly PI-positive membrane damage with mixed cell-death features. These findings identify linker functionalization and precursor selection as coupled design variables for tuning Fe-MOF structure, magnetoresponsive behavior, and chemotherapy-associated biological response. These findings identify linker functionalization and precursor selection as coupled design variables for tuning Fe-MOF structure, magnetoresponsive behavior, and chemotherapy-associated biological response.<\/jats:p>","DOI":"10.1021\/acsomega.6c05924","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:02:01Z","timestamp":1789520521000},"page":"57476-57490","source":"Crossref","is-referenced-by-count":0,"title":["Ligand Functionalization\nand Fe Precursor Selection\nModulated the Physicochemical Properties of Fe-MOFs and Their Biological\nResponse on Prostate Cancer and Normal Prostate Cells"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0463-4292","authenticated-orcid":true,"given":"Zehra","family":"Durmus","sequence":"first","affiliation":[{"name":"Martin Luther University Halle-Wittenberg , , ,","place":["Halle (Saale), Germany, 06120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem","family":"Kugu","sequence":"additional","affiliation":[{"name":"Gebze Technical University , , , ,","place":["Gebze, Kocaeli, Tu\u0308rkiye, 41400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihni Onur","family":"C\u0327al\u0131s\u0327kaner","sequence":"additional","affiliation":[{"name":"Biruni University , , ,","place":["Istanbul, Tu\u0308rkiye, 34015"]},{"name":"Biruni University , , ,","place":["Istanbul, Tu\u0308rkiye, 34015"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ko\u0308ferstein","sequence":"additional","affiliation":[{"name":"Martin Luther University Halle-Wittenberg , , ,","place":["Halle (Saale), Germany, 06120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus","family":"Lindenberg","sequence":"additional","affiliation":[{"name":"Martin Luther University Halle-Wittenberg , , ,","place":["Halle (Saale), Germany, 06120"]},{"name":"Martin Luther University Halle-Wittenberg , , ,","place":["Halle (Saale), Germany, 06120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-8345","authenticated-orcid":true,"given":"A. Wouter","family":"Maijenburg","sequence":"additional","affiliation":[{"name":"Martin Luther University Halle-Wittenberg , , ,","place":["Halle (Saale), Germany, 06120"]},{"name":"Martin Luther University Halle-Wittenberg , , ,","place":["Halle (Saale), Germany, 06120"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"2026092911123306500_cit1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.7150\/thno.80687","article-title":"Multifunctional\nmetal-organic framework (MOF)-based nanoplatforms for cancer therapy:\nfrom single to combination therapy","volume":"13","author":"Yang","year":"2023","journal-title":"Theranostics"},{"key":"2026092911123306500_cit2","doi-asserted-by":"publisher","first-page":"100139","DOI":"10.1016\/j.cinorg.2025.100139","article-title":"A comprehensive\nreview of metal-organic frameworks for biomedical applications: Practical\nchallenges and future potential","volume":"8","author":"Katke","year":"2026","journal-title":"Chem. Inorganic\nMater."},{"key":"2026092911123306500_cit3","doi-asserted-by":"publisher","first-page":"923","DOI":"10.70251\/HYJR2348.36923943","article-title":"Challenges\nIn the Clinical Translation of Metal Organic Frameworks: A Review","volume":"3","author":"Leung","year":"2025","journal-title":"Am. J. Stud. Res."},{"key":"2026092911123306500_cit4","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41578-023-00608-3","article-title":"Clinical translation\nof metal\u2013organic frameworks","volume":"8","author":"Tyagi","year":"2023","journal-title":"Nat. Rev.\nMater."},{"key":"2026092911123306500_cit5","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1039\/D5CC06724C","article-title":"Metal\u2013organic\nframeworks for natural medicines delivery: stimuli-responsive strategies\nand synergistic cancer therapy applications","volume":"62","author":"Mu","year":"2026","journal-title":"Chem. 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