{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:06:41Z","timestamp":1788876401825,"version":"build-2803163510"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["IRG-22-144-60"],"award-info":[{"award-number":["IRG-22-144-60"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006034","name":"University of Southern California","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100006034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007042","name":"Loker Hydrocarbon Research Institute, University of Southern California","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100007042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>C\u2013S bond formation via hydrogen atom transfer (HAT) remains underdeveloped despite the importance of thioethers in organic synthesis, materials science, and medicinal chemistry. Herein, we report a mild, rapid, and operationally simple method for the direct \u03b1-C(sp3)\u2013S bond formation in ethers using alkyl or aryl thiosulfonates as sulfur sources and (4-methoxyphenyl)(4-(trifluoromethyl)phenyl)methanone as the diaryl ketone catalyst. The reaction proceeds at room temperature under a 390 nm irradiation, delivering a broad range of thioethers in the absence of metals or stoichiometric oxidants. The method exhibits excellent functional group tolerance, predictable regioselectivity favoring the most hydridic C\u2013H bonds, and compatibility with various cyclic and acyclic ethers and amides. Preliminary mechanistic studies support a radical pathway consistent with a well-established photoexcited ketone-mediated HAT followed by radical addition to the thiosulfonate. This approach expands the toolkit for redox-neutral C(sp3)\u2013S bond construction.<\/jats:p>","DOI":"10.1021\/acsomega.6c06146","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:02:07Z","timestamp":1788177727000},"page":"53258-53264","source":"Crossref","is-referenced-by-count":0,"title":["Metal-Free Photoinduced\nHydrogen Atom Transfer for\nDirect Thiolation of Hydridic \u03b1-C(sp3)\u2013H\nof Ethers"],"prefix":"10.1021","volume":"11","author":[{"given":"Alexander","family":"Karr","sequence":"first","affiliation":[{"name":"University of Southern California , , 837 Bloom Walk , , ,","place":["Los Angeles, California, United States, 90089-1661"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5153-4131","authenticated-orcid":true,"given":"Elias","family":"Picazo","sequence":"additional","affiliation":[{"name":"University of Southern California , , 837 Bloom Walk , , ,","place":["Los Angeles, California, United States, 90089-1661"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"2026090809073873200_cit1","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1021\/ar200194b","article-title":"Innate and Guided\nC\u2013H Functionalization Logic","volume":"45","author":"Bru\u0308ckl","year":"2012","journal-title":"Acc. 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