{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:13:32Z","timestamp":1788437612714,"version":"build-2803163510"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective: This study aimed to engineer and characterize GelMA hydrogels and dual-cross-linked GelMA\u2013alginate hydrogels as tunable delivery platforms for antimicrobial peptides (AMPs; Histatin-5, GK-17, and INLK), and to evaluate their physicochemical properties, release kinetics, cytocompatibility, and antibiofilm efficacy against Candida albicans. Methods: Hydrogels with varying GelMA concentrations (5%, 7.5%, and 10%), with or without alginate, were fabricated and characterized in terms of microstructure, rheological and mechanical properties, swelling, degradation, and AMP release kinetics. Cytocompatibility was assessed using human gingival fibroblasts, and antimicrobial activity was evaluated through colony-forming unit counts, metabolic activity assays, biomass quantification, and confocal microscopy. Results: All hydrogels exhibited suitable moldability, pseudoplastic behavior, and structural stability. Increasing GelMA concentration and alginate incorporation enhanced mechanical properties: G10 displayed a higher compressive modulus (12,437.39 \u00b1 565.33 Pa; p &amp;lt; 0.0001) compared with the other GelMA-only groups, while G7.5A showed the highest value overall (18,090.45 \u00b1 2324.12 Pa; p &amp;lt; 0.0001). Sustained peptide release was observed over 48 h, with faster release from lower GelMA concentrations; G5 released 20.46% of Histatin-5-FAM after 48 h (p &amp;lt; 0.006). All formulations showed high cytocompatibility, with viability exceeding 100% at 24 h, indicating a stimulatory effect on fibroblast metabolic activity rather than mere absence of cytotoxicity. Hydrogels loaded with INLK or GK-17 significantly reduced C. albicans biofilm viability, biomass, and metabolic activity, whereas unloaded hydrogels showed no antifungal effect. G5-INLK reduced biofilm viability by approximately 1.6 log (p &amp;lt; 0.006) among the GelMA 5% groups, G7.5-INLK and G7.5-GK-17 reduced it by approximately 2 log (p &amp;lt; 0.0001), and G10-INLK produced a 0.9\u20131.2 log reduction. Conclusion: GelMA-based hydrogels provide a tunable and biocompatible platform for controlled AMP delivery, enabling effective disruption of C. albicans biofilms. This approach represents a promising strategy for the localized treatment of C. albicans-associated oral biofilm infections.<\/jats:p>","DOI":"10.1021\/acsomega.6c06773","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:02:28Z","timestamp":1786726948000},"page":"51951-51963","source":"Crossref","is-referenced-by-count":0,"title":["GelMA-Based Hydrogels\nfor Controlled Delivery of Antimicrobial\nPeptides against\n                    <i>Candida albicans<\/i>\n                    Biofilm"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-7258","authenticated-orcid":true,"given":"Beatriz","family":"Ribeiro Ribas","sequence":"first","affiliation":[{"name":"Sa\u0303o Paulo State University , , , ,","place":["Araraquara, Sa\u0303o Paulo, Brazil, 4800-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8360-1839","authenticated-orcid":true,"given":"Xavier L.","family":"Tabil","sequence":"additional","affiliation":[{"name":"University of Saskatchewan , , , ,","place":["Saskatoon, Saskatchewan, Canada, S7N 5A2"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongbiao","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Saskatchewan , , , ,","place":["Saskatoon, Saskatchewan, Canada, S7N 5A2"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-3658","authenticated-orcid":true,"given":"Walter Luiz","family":"Siqueira","sequence":"additional","affiliation":[{"name":"University of Saskatchewan , , , ,","place":["Saskatoon, Saskatchewan, Canada, S7N 5A2"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Buozi Moffa","sequence":"additional","affiliation":[{"name":"University Center , , , ,","place":["Sa\u0303o Joa\u0303o da Boa Vista, Sa\u0303o Paulo, Brazil, 13870-377"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaina Habib","family":"Jorge","sequence":"additional","affiliation":[{"name":"Sa\u0303o Paulo State University , , , ,","place":["Araraquara, Sa\u0303o Paulo, Brazil, 4800-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"issue":"1","key":"2026090307195306100_cit1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/odi.12224","article-title":"Microbiota and their role in the pathogenesis of oral mucositis","volume":"21","author":"Vanhoecke","year":"2015","journal-title":"Oral Diseases"},{"issue":"2","key":"2026090307195306100_cit2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/1758-2229.13053","article-title":"In it together:\nCandida-bacterial oral biofilms and therapeutic strategies","volume":"14","author":"Hwang","year":"2022","journal-title":"Environ. Microbiol. Rep."},{"issue":"4","key":"2026090307195306100_cit3","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.diagmicrobio.2013.05.001","article-title":"Opportunistic microorganisms\nin individuals with lesions of denture stomatitis","volume":"76","author":"Pereira","year":"2013","journal-title":"Diagn. Microbiol. Infect. Dis."},{"issue":"7","key":"2026090307195306100_cit4","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/jop.12905","article-title":"Polymicrobial\ninteractions of Candida albicans and its role in\noral carcinogenesis","volume":"48","author":"Arzmi","year":"2019","journal-title":"J. Oral Pathol. 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