{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:56:18Z","timestamp":1791302178526,"version":"4.1.0"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["308880\/2021-8"],"award-info":[{"award-number":["308880\/2021-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["405165\/2023-4"],"award-info":[{"award-number":["405165\/2023-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\u03b2-Cyclodextrin (\u03b2-CD) encapsulation may offer a strategic approach to overcome the high volatility of nerolidol (NE) for controlling Botrytis cinerea decay in postharvest strawberries. In this study, a \u03b2-cyclodextrin\/nerolidol inclusion complex (\u03b2-CD\/NE) was prepared by freeze-drying to improve the stability and performance of NE. The complex exhibited high complexation efficiency (96.71%) and nanoscale particle size (484.9 nm). FTIR, XRD, and thermal analyses evidenced strong molecular interactions and structural modifications, and an improvement in the thermal stability of the sesquiterpene, while solid-state 13C NMR and SAXS indicates the formation of host\u2013guest inclusion complex through the appearance of characteristic nerolidol resonances and structural modifications in the \u03b2-CD matrix. The \u03b2-CD\/NE showed significantly higher antifungal activity against B. cinerea than free NE in vitro, with inhibition increasing from 17.9% to 65.8% between 200 and 6400 \u03bcM, while free NE reached a maximum inhibition of 43.6% at the same concentration range. Strawberries treated with \u03b2-CD\/NE and stored at 5 \u00b0C for 10 days showed a visible decrease of fungal growth and a significant reduction in mass loss compared to untreated fruits, suggesting a high preservation potential. This study advances the application of natural antifungal systems, as the utilization of \u03b2-CD\/NE inclusion complex as a postharvest antifungal system against B. cinerea in strawberries has not been reported elsewhere.<\/jats:p>","DOI":"10.1021\/acsomega.6c06824","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:01:20Z","timestamp":1790434880000},"page":"59828-59839","source":"Crossref","is-referenced-by-count":0,"title":["\u03b2-Cyclodextrin\/Nerolidol\nInclusion Complex\nas a Potential Ecofriendly Antifungal System against\n                    <i>Botrytis cinerea<\/i>\n                    in Postharvest Strawberries"],"prefix":"10.1021","volume":"11","author":[{"given":"Aldrey N. R.","family":"Corre\u0302a","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul , , ,","place":["Porto Alegre, Brazil, 91501-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara E.","family":"Zanotelli","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul , , ,","place":["Porto Alegre, Brazil, 91501-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica F.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Rio dos Sinos , , ,","place":["Sa\u0303o Leopoldo, Brazil, 93022-750"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9307-6471","authenticated-orcid":true,"given":"Adriano","family":"Brandelli","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul , , ,","place":["Porto Alegre, Brazil, 91501-970"]},{"name":"Universidade Federal do Rio Grande do Sul , , ,","place":["Porto Alegre, Brazil, 91501-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"2026100610502965800_cit1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.tplants.2022.08.024","article-title":"Killing softly: a roadmap\nof Botrytis cinerea pathogenicity","volume":"28","author":"Bi","year":"2023","journal-title":"Trends Plant\nSci."},{"key":"2026100610502965800_cit2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41538-025-00477-w","article-title":"Current status\nand future trends of eco-friendly management of postharvest fungal\ndecays in tomato fruit","volume":"9","author":"Wang","year":"2025","journal-title":"npj Sci. Food"},{"key":"2026100610502965800_cit3","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1111\/mpp.12794","article-title":"Grey mould\nof strawberry, a devastating disease caused by the ubiquitous necrotrophic\nfungal pathogen Botrytis cinerea","volume":"20","author":"Petrasch","year":"2019","journal-title":"Mol. Plant\nPathol."},{"key":"2026100610502965800_cit4","doi-asserted-by":"publisher","first-page":"795","DOI":"10.3390\/coatings9120795","article-title":"Fungicides\nfilms of low-density polyethylene (LDPE)\/inclusion complexes (carvacrol\nand cinnamaldehyde) against Botrytis cinerea","volume":"9","author":"Canales","year":"2019","journal-title":"Coatings"},{"key":"2026100610502965800_cit5","doi-asserted-by":"publisher","first-page":"116401","DOI":"10.1016\/j.foodres.2025.116401","article-title":"A predictive\napproach to reducing\nstrawberry post-harvest waste: impact of storage conditions and water\nactivity on Botrytis cinerea germination","volume":"210","author":"Rabasco-Vi\u0301lchez","year":"2025","journal-title":"Food\nRes. Int."},{"key":"2026100610502965800_cit6","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1007\/s11694-020-00765-x","article-title":"Chemical composition and antifungal activity of essential\noils and their combinations against Botrytis cinerea in strawberries","volume":"15","author":"Oliveira Filho","year":"2021","journal-title":"J. Food Meas. Charact."},{"key":"2026100610502965800_cit7","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.scienta.2017.06.062","article-title":"UV-C enhances\nresistance against gray mold decay caused by Botrytis\ncinerea in strawberry fruit","volume":"225","author":"Jin","year":"2017","journal-title":"Sci. Hortic."},{"key":"2026100610502965800_cit8","doi-asserted-by":"publisher","first-page":"103308","DOI":"10.1016\/j.pmpp.2026.103308","article-title":"Biocontrol\nof Botrytis cinerea in\nstrawberry using epiphytic bacteria from Fragaria \u00d7 ananassa,\nRubus idaeus and Vaccinium corymbosum leaves","volume":"145","author":"Radi","year":"2026","journal-title":"Physiol. Mol. Plant Pathol."},{"key":"2026100610502965800_cit9","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.3390\/biom12091271","article-title":"Antibacterial and\nantifungal sesquiterpenoids: chemistry, resource, and activity","volume":"12","author":"Li","year":"2022","journal-title":"Biomolecules"},{"key":"2026100610502965800_cit10","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.foodchem.2018.02.055","article-title":"First evaluation of drug-in-cyclodextrin-in-liposomes\nas an encapsulating system for nerolidol","volume":"255","author":"Azzi","year":"2018","journal-title":"Food\nChem."},{"key":"2026100610502965800_cit11","doi-asserted-by":"publisher","first-page":"118742","DOI":"10.1016\/j.lfs.2020.118742","article-title":"Nerolidol-beta-cyclodextrin inclusion\ncomplex enhances anti-inflammatory activity in arthritis model and\nimproves gastric protection","volume":"265","author":"de Souza","year":"2021","journal-title":"Life Sci."},{"key":"2026100610502965800_cit12","unstructured":"Food and Drug Administration (FDA).\n          . Part 172 food additives\npermitted for direct addition to food for human consumption. Flavoring\nAgents and Related Substances. 2021. https:\/\/www.ecfr.gov\/current\/title-21\/chapter-I\/subchapter-B\/part-172. Accessed in 6 January 2026."},{"key":"2026100610502965800_cit13","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.procbio.2019.02.015","article-title":"Selection\nof nerolidol among a series of terpenic and phenolic compounds for\nits potent activity against Lactobacillus fermentum ATCC 9338","volume":"80","author":"Ephrem","year":"2019","journal-title":"Process Biochem."},{"key":"2026100610502965800_cit14","doi-asserted-by":"publisher","first-page":"134410","DOI":"10.1016\/j.foodchem.2022.134410","article-title":"Preparation,\ncharacterization, and antioxidant activity of \u03b2-cyclodextrin\nnanoparticles loaded Rosa damascena essential oil\nfor application in beverage","volume":"403","author":"Hadian","year":"2023","journal-title":"Food Chem."},{"key":"2026100610502965800_cit15","doi-asserted-by":"publisher","first-page":"125063","DOI":"10.1016\/j.carbpol.2026.125063","article-title":"Cyclodextrin-enhanced\nedible coatings for extending\nshelf life of perishable foods: A comprehensive review with emphasis\non fruits and vegetables","volume":"380","author":"Supaphol","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"2026100610502965800_cit16","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.ijpharm.2017.06.010","article-title":"Amphiphilic cyclodextrin nanoparticles","volume":"531","author":"Varan","year":"2017","journal-title":"Int. J. Pharm."},{"key":"2026100610502965800_cit17","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1007\/S11947-017-1926-Z","article-title":"Application of \u03b2-cyclodextrin\/2-nonanone\ninclusion\ncomplex as active agent to design of antimicrobial packaging films\nfor control of Botrytis cinerea","volume":"10","author":"Abarca","year":"2017","journal-title":"Food Bioprocess\nTechnol."},{"key":"2026100610502965800_cit18","doi-asserted-by":"publisher","first-page":"802","DOI":"10.3390\/cryst15090802","article-title":"Selective crystallization\nof trans-nerolidol in \u03b2-cyclodextrin: crystal structure and\nmolecular dynamics analysis","volume":"15","author":"Christoforides","year":"2025","journal-title":"Crystals"},{"key":"2026100610502965800_cit19","doi-asserted-by":"publisher","first-page":"110795","DOI":"10.1016\/j.fct.2019.110795","article-title":"Use of free\nand encapsulated nerolidol to inhibit the survival of Lactobacillus fermentum in fresh orange juice","volume":"133","author":"Ephrem","year":"2019","journal-title":"Food\nChem. Toxicol."},{"key":"2026100610502965800_cit20","doi-asserted-by":"publisher","first-page":"102584","DOI":"10.1016\/j.fochx.2025.102584","article-title":"Nerolidol\/hydroxypropyl-beta-cyclodextrin\ninclusion complex nanofibers: active food packaging for effective\nstrawberry preservation","volume":"28","author":"Zhang","year":"2025","journal-title":"Food Chem. X"},{"key":"2026100610502965800_cit21","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1007\/s13197-019-03747-0","article-title":"Antifungal activity\nof thymol and carvacrol against postharvest pathogens Botrytis cinerea","volume":"56","author":"Zhang","year":"2019","journal-title":"J. Food Sci. Technol."},{"key":"2026100610502965800_cit22","doi-asserted-by":"publisher","first-page":"150168","DOI":"10.1016\/j.ijbiomac.2026.150168","article-title":"Nanostructured\nstarch-based films incorporating essential oil and nerolidol-loaded\nnanoparticles for postharvest protection of strawberries","volume":"340","author":"Corre\u0302a","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"2026100610502965800_cit23","doi-asserted-by":"publisher","first-page":"138926","DOI":"10.1016\/j.foodchem.2024.138926","article-title":"Encapsulation of 4-terpineol\nwith \u03b2-cyclodextrin: inclusion mechanism, characterization and\nrelative humidity-triggered release","volume":"447","author":"Cheng","year":"2024","journal-title":"Food Chem."},{"key":"2026100610502965800_cit24","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.vetpar.2016.06.007","article-title":"Repellent effects of Melaleuca alternifolia (tea\ntree) oil against cattle tick\nlarvae (Rhipicephalus australis) when formulated\nas emulsions and in \u03b2-cyclodextrin inclusion complexes","volume":"225","author":"Yim","year":"2016","journal-title":"Vet. Parasitol."},{"key":"2026100610502965800_cit25","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1007\/s00436-020-06963-2","article-title":"In vitro\nand in vivo evaluation of cnicin from blessed\nthistle (Centaurea benedicta) and its inclusion complexes\nwith cyclodextrins against Schistosoma mansoni","volume":"120","author":"Queiroz","year":"2021","journal-title":"Parasitol. Res."},{"key":"2026100610502965800_cit26","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1021\/la203673w","article-title":"Cyclodextrin\u2013surfactant\ncoassembly depends on the cyclodextrin ability to crystallize","volume":"28","author":"Carlstedt","year":"2012","journal-title":"Langmuir"},{"key":"2026100610502965800_cit27","doi-asserted-by":"publisher","first-page":"12888","DOI":"10.1021\/jp802031w","article-title":"Native and methylated\ncyclodextrins with positive and negative solubility coefficients in\nwater studied by SAXS and SANS","volume":"112","author":"Kusmin","year":"2008","journal-title":"J. Phys. Chem.\nB"},{"key":"2026100610502965800_cit28","doi-asserted-by":"publisher","first-page":"105948","DOI":"10.1016\/j.foodhyd.2020.105948","article-title":"Size and shape\nof cycloamylose estimated\nusing column chromatography coupled with small-angle X-ray scattering","volume":"108","author":"Takemasa","year":"2020","journal-title":"Food Hydrocoll."},{"key":"2026100610502965800_cit29","doi-asserted-by":"publisher","first-page":"123819","DOI":"10.1016\/j.carbpol.2025.123819","article-title":"Sustainable aroma absorption:\nexploring the potentiality of a \u03b2-cyclodextrin and lactic acid\nsupramolecular eutectic solvent","volume":"366","author":"Mangiacapre","year":"2025","journal-title":"Carbohydr.\nPolym."},{"key":"2026100610502965800_cit30","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1080\/10412905.1998.9701017","article-title":"Seasonal variation\nof (E)-nerolidol\nin Siparuna guianensis Aublet and 13C-NMR spectral\nassignments of (E)-and (Z)-nerolidol","volume":"10","author":"Machado","year":"1998","journal-title":"J. Essent.\nOil Res."},{"key":"2026100610502965800_cit31","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1590\/S0103-50532002000300008","article-title":"Tetranortriterpenoids and dihydrocinnamic\nacid derivatives from Hortia colombiana","volume":"13","author":"Suarez","year":"2002","journal-title":"J. Braz. Chem. Soc."},{"key":"2026100610502965800_cit32","doi-asserted-by":"publisher","first-page":"110441","DOI":"10.1016\/j.foodhyd.2024.110441","article-title":"Supramolecular chemistry in cyclodextrin inclusion\ncomplexes: the formation rules of terpenes\/\u03b2-cyclodextrin inclusion\ncomplexes","volume":"157","author":"Kou","year":"2024","journal-title":"Food Hydrocoll."},{"key":"2026100610502965800_cit33","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3390\/molecules21050529","article-title":"Nerolidol:\na sesquiterpene alcohol with multi-faceted pharmacological and biological\nactivities","volume":"21","author":"Chan","year":"2016","journal-title":"Molecules"},{"key":"2026100610502965800_cit34","doi-asserted-by":"publisher","first-page":"128403","DOI":"10.1016\/j.foodchem.2020.128403","article-title":"Essential oils as additives\nin active food packaging","volume":"343","author":"Sharma","year":"2021","journal-title":"Food Chem."},{"key":"2026100610502965800_cit35","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.foodres.2019.03.026","article-title":"Antifungal and physicochemical properties\nof inclusion complexes based on \u03b2-cyclodextrin and essential\noil derivatives","volume":"121","author":"Herrera","year":"2019","journal-title":"Food Res. Int."},{"key":"2026100610502965800_cit36","doi-asserted-by":"publisher","first-page":"110724","DOI":"10.1016\/j.foodhyd.2024.110724","article-title":"Nanoencapsulated cinnamaldehyde@\u03b2-cyclodextrin\ninclusion complexes as a sustained release strategy for postharvest\nrambutan preservation","volume":"159","author":"Shu","year":"2025","journal-title":"Food Hydrocoll."},{"key":"2026100610502965800_cit37","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.postharvbio.2018.09.012","article-title":"A novel\napproach to determine the impact level of each step along the supply\nchain on strawberry quality","volume":"147","author":"Kelly","year":"2019","journal-title":"Postharvest Biol.\nTechnol."},{"key":"2026100610502965800_cit38","doi-asserted-by":"publisher","first-page":"111339","DOI":"10.1016\/j.foodcont.2025.111339","article-title":"Advanced evaluation\nof strawberry quality, consumer\npreference, and cultivar discrimination through spectral imaging and\nneural networks","volume":"175","author":"Castillo-Girones","year":"2025","journal-title":"Food Control"},{"key":"2026100610502965800_cit39","doi-asserted-by":"publisher","DOI":"10.1111\/jfpp.13063","article-title":"Effect\nof plasticizer and modified starch on biodegradable\nfilms for strawberry protection","volume":"41","author":"Franco","year":"2017","journal-title":"J. Food Process.\nPreserv."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c06824","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/39\/59828\/68665971\/acsomega.6c06824.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/39\/59828\/68665971\/acsomega.6c06824.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:17:55Z","timestamp":1791299875000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/39\/59828\/5439311\/Cyclodextrin-Nerolidol-Inclusion-Complex-as-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,26]]},"references-count":39,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2026,9,26]]},"published-print":{"date-parts":[[2026,10,6]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c06824","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,26]]}}}