{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:18:31Z","timestamp":1788218311046,"version":"build-2803163510"},"reference-count":112,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Environmental micro- and nanoplastics (MNPs) are increasingly recognized as biologically active particulate contaminants, yet their influence on amyloid-beta (A\u03b2) structural behavior and oxidative chemistry remains insufficiently defined. In this study, consumer-derived polyethylene terephthalate (PET) MNPs were used as a real-world contaminant model to evaluate time-dependent interactions with A\u03b2 at subagglomeration peptide concentrations. A\u03b2 solutions (0.1\u20131000 pg\/mL) were exposed to PET MNPs (10, 40, and 100 \u03bcg\/mL) for 1\u2013144 h and assessed using fluorescence spectroscopy, apparent Stern\u2013Volmer-type analysis, turbidity, Rayleigh light scattering (RLS), zeta potential, dynamic light scattering (DLS), FTIR, Raman spectroscopy, UV\u2013Vis slope factor analysis, cell-free dithiothreitol oxidative potential, and molecular docking. PET MNP exposure produced wavelength-, concentration-, dose-, and time-dependent fluorescence modulation. Apparent Stern\u2013Volmer slopes were small and bidirectional rather than uniformly positive, indicating nonclassical fluorescence behavior rather than a single dynamic quenching or binding mechanism. Turbidity and RLS increased mainly during early exposure, suggesting formation of light-scattering A\u03b2\u2013MNP-associated assemblies, whereas prolonged exposure was associated with reduced scattering signals, nanoscale DLS profiles, and fluctuating zeta potentials, indicating a change in the abundance or scattering behavior of species remaining in the measured postfiltration phase. The available data cannot distinguish interfacial reorganization from microsedimentation, localized precipitation, nonspecific vessel-wall adsorption, filtration-sensitive loss, or altered scattering efficiency. FTIR and Raman results indicated changes in Amide II\/III, C\u2013O\/C\u2013H, and aromatic-residue-associated regions, while DTT results showed modest but measurable enhancement of cell-free oxidative potential. Docking simulations suggested possible PET\u2013A\u03b2 contacts involving aggregation-prone aromatic and polar residues, providing mechanistic support for interfacial association. Overall, PET MNPs are best interpreted as dynamic modulators of A\u03b2 colloidal, structural, and oxidative behavior, initially favoring A\u03b2\u2013MNP association and followed by later changes in the nanoscale, spectroscopic, and optical characteristics of the measured phase, without establishing a specific aggregate morphology or late-stage mechanism.<\/jats:p>","DOI":"10.1021\/acsomega.6c06885","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T17:02:01Z","timestamp":1786640521000},"page":"50442-50460","source":"Crossref","is-referenced-by-count":0,"title":["Micro\/Nanoplastics\nDrive Amyloid-\u03b2 Colloidal\nand Oxidative Reorganization: A Real-World Contaminant Stressor"],"prefix":"10.1021","volume":"11","author":[{"given":"Hasan","family":"Saygin","sequence":"first","affiliation":[{"name":"Istanbul Aydin University , , Sefakoy, Kucukcekmece , ,","place":["Istanbul, Turkiye, 34295"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0178-7808","authenticated-orcid":true,"given":"Asli","family":"Baysal","sequence":"additional","affiliation":[{"name":"Istanbul Technical University , , Maslak, Sariyer , ,","place":["Istanbul, Turkiye, 34467"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Apaydin","sequence":"additional","affiliation":[{"name":"Marmara University , , ,","place":["Istanbul, Turkiye, 34854"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3043-0015","authenticated-orcid":true,"given":"Pemra","family":"Ozbek","sequence":"additional","affiliation":[{"name":"Marmara University , , ,","place":["Istanbul, Turkiye, 34854"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"8","key":"2026083119112573900_cit1","doi-asserted-by":"publisher","first-page":"4063","DOI":"10.1039\/D2NR05787E","article-title":"A label-free electrochemical immunosensor based on\nAu-BSN-rGO for highly sensitive detection of \u03b2-amyloid 1\u201342","volume":"15","author":"Li","year":"2023","journal-title":"Nanoscale"},{"issue":"6","key":"2026083119112573900_cit2","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3390\/bios13060610","article-title":"A novel aggregation-induced\nemission fluorescent probe for detection of \u03b2-amyloid based\non pyridinyltriphenylamine and quinoline-malononitrile","volume":"13","author":"Fang","year":"2023","journal-title":"Biosensors"},{"key":"2026083119112573900_cit3","doi-asserted-by":"publisher","first-page":"342894","DOI":"10.1016\/j.aca.2024.342894","article-title":"Novel pyrrolidine-alkylamino-substituted\ndicyanoisophorone derivatives\nas near-infrared fluorescence probe for imaging \u03b2-amyloid in\nvitro and in vivo","volume":"1317","author":"Zhou","year":"2024","journal-title":"Anal. 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