{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:13:04Z","timestamp":1788221584385,"version":"build-2803163510"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Malondialdehyde (MDA) is a critical biomarker of oxidative stress, playing a significant role in diagnosing and monitoring conditions associated with oxidative damage, including cardiovascular diseases, neurodegenerative disorders, and cancer. This study reports the synthesis and application of a molecularly imprinted polymer (MIP)-based electrochemical sensor for MDA detection using a dual biopolymer chitosan\/\u03ba-carrageenan matrix integrated with Fe3O4 nanoparticles on a boron-doped diamond (BDD) electrode. Differential pulse voltammetry (DPV) was employed to evaluate analyte recognition, while FTIR, DLS, SEM, EIS, and cyclic voltammetry were used for sensor characterization. Under optimized conditions (75% chitosan, 25% \u03ba-carrageenan, and 10 mg Fe3O4 nanoparticles), the sensor exhibited high sensitivity (687.35 \u03bcA\/\u03bcM), a low detection limit (0.005 \u03bcM), and a linear detection range of 0.026\u20130.26 \u03bcM. The developed platform also demonstrated good reproducibility, repeatability, and selectivity toward MDA in the presence of common interfering compounds. Analytical performance was further validated in spiked water and artificial serum samples, showing satisfactory recovery values. The proposed sensor outperformed several previously reported MDA sensing platforms, highlighting its potential as a sensitive and reliable tool for oxidative stress biomarker detection and future clinical applications.<\/jats:p>","DOI":"10.1021\/acsomega.6c06926","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:01:36Z","timestamp":1786510896000},"page":"50461-50470","source":"Crossref","is-referenced-by-count":0,"title":["Toward Precision\nin Biomarker Analysis: A Novel Malondialdehyde\nDetection Method Based on Molecularly Imprinted Polymers"],"prefix":"10.1021","volume":"11","author":[{"given":"Marise","family":"Nouhra","sequence":"first","affiliation":[{"name":"Notre Dame University\u2500Louaize , , P.O. Box ,","place":["Zouk Mosbeh, Lebanon, 72"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-2227","authenticated-orcid":true,"given":"Rita","family":"Maalouf","sequence":"additional","affiliation":[{"name":"Notre Dame University\u2500Louaize , , P.O. Box ,","place":["Zouk Mosbeh, Lebanon, 72"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Sawan","sequence":"additional","affiliation":[{"name":"Notre Dame University\u2500Louaize , , P.O. 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J."},{"key":"2026083119134468100_cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114408","article-title":"Molecularly imprinted\npolymers (MIPs) for SARS-CoV-2 omicron variant inhibition: An alternative\napproach to address the challenge of emerging zoonoses","volume":"247","author":"Dattilo","year":"2025","journal-title":"Colloids Surf., B"},{"issue":"2","key":"2026083119134468100_cit32","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s40199-022-00447-7","article-title":"Novel biodegradable\nmolecularly imprinted polymer nanoparticles for drug delivery of methotrexate\nanti-cancer; synthesis, characterization and cellular studies","volume":"30","author":"Yoosefi","year":"2022","journal-title":"DARU J. Pharm. Sci."},{"issue":"18","key":"2026083119134468100_cit33","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26185612","article-title":"Factors Affecting Preparation\nof Molecularly Imprinted Polymer and Methods on Finding Template-Monomer\nInteraction as the Key of Selective Properties of the Materials","volume":"26","author":"Hasanah","year":"2021","journal-title":"Molecules"},{"issue":"8","key":"2026083119134468100_cit34","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1002\/mabi.200500065","article-title":"Controlling\ndrug release from imprinted\nhydrogels by modifying the characteristics of the imprinted cavities","volume":"5","author":"Hiratani","year":"2005","journal-title":"Macromol. Biosci."},{"issue":"42","key":"2026083119134468100_cit35","doi-asserted-by":"publisher","first-page":"49595","DOI":"10.1021\/acsami.3c09696","article-title":"Improving the Selectivity\nof the C-C Coupled Product Electrosynthesis by Using Molecularly Imprinted\nPolymer\u2500An Enhanced Route from Phenol to Biphenol","volume":"15","author":"Sudagar","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026083119134468100_cit36","doi-asserted-by":"publisher","DOI":"10.3390\/s20092677","article-title":"How Reliable Is\nthe Electrochemical Readout of MIP\nSensors?","volume":"20","author":"Yarman","year":"2020","journal-title":"Sensors"},{"key":"2026083119134468100_cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116018","article-title":"Recent advances in molecularly imprinted polymer-based\nelectrochemical sensors","volume":"249","author":"Li","year":"2024","journal-title":"Biosens. 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Biomed.\nAnal."},{"issue":"11","key":"2026083119134468100_cit40","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1007\/s00216-023-04594-x","article-title":"Rapid\ndetermination of malondialdehyde in serum samples using a porphyrin-functionalized\nmagnetic graphene oxide electrochemical sensor","volume":"415","author":"Ben Attig","year":"2023","journal-title":"Anal. Bioanal. 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