{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:47:03Z","timestamp":1792784823789,"version":"4.5.0"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 99-2320-B-077-007"],"award-info":[{"award-number":["NSC 99-2320-B-077-007"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Institute of Chinese Medicine","award":["MOHW114-NRICM-M-315-000004"],"award-info":[{"award-number":["MOHW114-NRICM-M-315-000004"]}],"id":[{"id":"https:\/\/ror.org\/00nnyvd56","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Research Institute of Chinese Medicine","award":["NRICM 99-DMC-006"],"award-info":[{"award-number":["NRICM 99-DMC-006"]}],"id":[{"id":"https:\/\/ror.org\/00nnyvd56","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study reports the first total syntheses of the naturally occurring flavonoids ugonin C (1), ugonin F (2), and, based on the originally proposed structures, compounds 3 and 4 (corresponding to the structures first assigned to ugonin T and neougonin B, respectively), all featuring a dihydrofuran ring fused to a phenolic moiety. In addition, a series of analogues (18, 19, 22, 23a, 23b, 27a, 27b, and 28) were synthesized to explore their biological activities. On the basis of synthetic strategy and detailed NMR analyses, the structures of naturally occurring ugonin T and neougonin B were reassigned to correspond to compounds 23a and 19, respectively. Biological evaluation revealed that several synthesized compounds exhibited potent anti-inflammatory activity, particularly compound 27a, which showed the strongest inhibition of NF-\u03baB associated nitric oxide production in BV2 microglial cells.<\/jats:p>","DOI":"10.1021\/acsomega.6c07093","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:01:58Z","timestamp":1789545718000},"page":"57906-57917","source":"Crossref","is-referenced-by-count":0,"title":["Total Syntheses\nand Structural Reassignment of Ugonin\nT and Neougonin B: Anti-inflammatory Flavonoids Related to\n                    <i>Helminthostachys zeylanica<\/i>"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0895-1428","authenticated-orcid":true,"given":"Yuh-Chiang","family":"Shen","sequence":"first","affiliation":[{"name":"National Taipei University of Nursing and Health Science , , ,","place":["Taipei City, Taiwan, 112303"]},{"name":"National Research Institute of Chinese Medicine , No. 155-1, Sec. 2, Linong Street , Beitou Dist., ,","place":["Taipei, Taiwan, 11221"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Taipei , , No.1, Ai-Guo West Road , ,","place":["Taipei, Taiwan, 100234"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San-Yao","family":"Su","sequence":"additional","affiliation":[{"name":"Chinese Culture University , , No. 55, Hwa-Kang Road, Yang-Ming-Shan , ,","place":["Taipei, Taiwan, 11114"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jyung","family":"Lin","sequence":"additional","affiliation":[{"name":"National Taiwan University , , No. 1, Section 4, Roosevelt Rd , ,","place":["Taipei, Taiwan, 106309"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-You","family":"Lai","sequence":"additional","affiliation":[{"name":"Chinese Culture University , , No. 55, Hwa-Kang Road, Yang-Ming-Shan , ,","place":["Taipei, Taiwan, 11114"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Chinese Culture University , , No. 55, Hwa-Kang Road, Yang-Ming-Shan , ,","place":["Taipei, Taiwan, 11114"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Taipei , , No.1, Ai-Guo West Road , ,","place":["Taipei, Taiwan, 100234"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-Pei","family":"Kao","sequence":"additional","affiliation":[{"name":"National Research Institute of Chinese Medicine , No. 155-1, Sec. 2, Linong Street , Beitou Dist., ,","place":["Taipei, Taiwan, 11221"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-1013","authenticated-orcid":true,"given":"Ming-Jaw","family":"Don","sequence":"additional","affiliation":[{"name":"National Research Institute of Chinese Medicine , No. 155-1, Sec. 2, Linong Street , Beitou Dist., ,","place":["Taipei, Taiwan, 11221"]},{"name":"University of Taipei , , No.1, Ai-Guo West Road , ,","place":["Taipei, Taiwan, 100234"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0650-4600","authenticated-orcid":true,"given":"Yea-Hwey","family":"Wang","sequence":"additional","affiliation":[{"name":"National Taipei University of Nursing and Health Science , , ,","place":["Taipei City, Taiwan, 112303"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"2026092911091705300_cit1","first-page":"18","volume-title":"The Illustrated Medicinal\nPlants of Taiwan","author":"Chiu","year":"1992"},{"key":"2026092911091705300_cit2","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1248\/cpb.21.1851","article-title":"Chemical Studies\non the Constituents of Helminthostachys zeylanica (L.) 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