{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:25:38Z","timestamp":1786465538858,"version":"build-2736575974"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","award":["2026-M3-2-409-1"],"award-info":[{"award-number":["2026-M3-2-409-1"]}],"id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mindray Medical International Limited","award":["2026-M3-2-409-1"],"award-info":[{"award-number":["2026-M3-2-409-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The increasing burden of Acute Kidney Injury (AKI) significantly impacts human health. Approximately 70% of septic patients develop AKI, which markedly increases the risk of in-hospital mortality. However, current treatment for Sepsis-Associated Acute Kidney Injury (SA-AKI) is mainly supportive, and no specific therapy is available. siRNA therapy is an emerging approach that inhibits mRNA of specific targets to exert therapeutic effects. Based on the gene silencing principle of siRNA, we developed a targeted bifunctional coloaded nanoparticle, PDA@Cur\u2013PEI-PEG-FA\/siRela (PCPPFS), using folic acid (FA) as a targeting moiety. In this system, curcumin acts as a therapeutic agent and synergizes with siRela to exert anti-inflammatory and antioxidative stress effects, thereby reducing apoptosis and pyroptosis of renal tubular epithelial cells. This nanosystem demonstrated good targeting and therapeutic effects in both in vitro and in vivo experiments, providing a new approach for SA-AKI therapy.<\/jats:p>","DOI":"10.1021\/acsomega.6c07405","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:58:35Z","timestamp":1785157115000},"page":"47148-47161","source":"Crossref","is-referenced-by-count":0,"title":["Folate-Targeted\nCo-Delivery of Curcumin and siRela\nNanoparticles Synergistically Treat Sepsis-Associated Acute Kidney\nInjury"],"prefix":"10.1021","volume":"11","author":[{"given":"Xiangyi","family":"Xu","sequence":"first","affiliation":[{"name":"Peking University Health Science Center , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjin","family":"Tao","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjun","family":"Shen","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Nie","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huike","family":"Guo","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxin","family":"Li","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Pei","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9269-3880","authenticated-orcid":true,"given":"Chengqian","family":"Ma","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Yang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-3997","authenticated-orcid":true,"given":"Liyan","family":"Cui","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]},{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"issue":"11","key":"2026081110194081000_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25115924","article-title":"Acute Kidney Injury in Sepsis","volume":"25","author":"Pais","year":"2024","journal-title":"Int. J. Mol. 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Pharmacother."},{"key":"2026081110194081000_cit7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.ejphar.2016.08.013","article-title":"Tenuigenin\nexhibits protective effects against LPS-induced acute kidney injury\nvia inhibiting TLR4\/NF-\u03baB signaling pathway","volume":"791","author":"Fu","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"2026081110194081000_cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108395","article-title":"Dimethyl fumarate attenuates LPS\ninduced septic acute kidney injury\nby suppression of NF\u03baB p65 phosphorylation and macrophage activation","volume":"102","author":"Tang","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"2026081110194081000_cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00859-z","article-title":"Downregulation\nof macrophage migration inhibitory factor attenuates NLRP3 inflammasome\nmediated pyroptosis in sepsis-induced AKI","volume":"8","author":"Li","year":"2022","journal-title":"Cell\nDeath Discovery"},{"key":"2026081110194081000_cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117101","article-title":"Polygonum cuspidatum Sieb. et Zucc.\nExtracts improve sepsis-associated acute kidney injury by inhibiting\nNF-?B-mediated inflammation and pyroptosis","volume":"319","author":"Yang","year":"2024","journal-title":"J. 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Immunopharmacol."},{"issue":"7","key":"2026081110194081000_cit30","first-page":"1083","article-title":"Fortunellin attenuates\nsepsis-induced acute kidney injury by inhibiting inflammation and\nferroptosis via the TLR4\/NF-\u03baB pathway","volume":"40","author":"Liu","year":"2025","journal-title":"Histol. Histopathol."},{"issue":"1","key":"2026081110194081000_cit31","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-025-03977-9","article-title":"Ursodeoxycholic\nacid protects against sepsis-induced acute kidney injury by activating\nNrf2\/HO-1 and inhibiting NF-\u03baB pathway","volume":"26","author":"Lou","year":"2025","journal-title":"BMC Nephrol."},{"key":"2026081110194081000_cit32","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/8759766","article-title":"Parthenolide\nAttenuates Sepsis-Induced\nAcute Kidney Injury in Rats by Reducing Inflammation","volume":"2023","author":"Shou","year":"2023","journal-title":"Evidence-Based Complementary Altern. 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Pharmacol."},{"issue":"6","key":"2026081110194081000_cit41","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1021\/acsbiomaterials.9b00119","article-title":"Folate Receptor-Mediated\nRenal-Targeting Nanoplatform for the Specific Delivery of Triptolide\nto Treat Renal Ischemia\/Reperfusion Injury","volume":"5","author":"Huang","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"2","key":"2026081110194081000_cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03431-2","article-title":"Gasdermin\nE deficiency attenuates acute kidney injury by inhibiting pyroptosis\nand inflammation","volume":"12","author":"Xia","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"2026081110194081000_cit43","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-025-04077-4","article-title":"Molecular mechanisms\nand therapeutic interventions in acute kidney injury: a literature\nreview","volume":"26","author":"He","year":"2025","journal-title":"BMC Nephrol."},{"key":"2026081110194081000_cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110105","article-title":"Klotho alleviates\ncontrast-induced acute kidney injury by suppressing oxidative stress,\ninflammation, and NF-KappaB\/NLRP3-mediated pyroptosis","volume":"118","author":"Fu","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"2026081110194081000_cit45","doi-asserted-by":"publisher","DOI":"10.3390\/jfb15090249","article-title":"Dihydromyricetin Nanoparticles Alleviate\nLipopolysaccharide-Induced Acute Kidney Injury by Decreasing Inflammation\nand Cell Apoptosis via the TLR4\/NF-\u03baB Pathway","volume":"15","author":"Yin","year":"2024","journal-title":"J. Funct. Biomater."},{"key":"2026081110194081000_cit46","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.2147\/DDDT.S379629","article-title":"Baicalin Alleviates\nContrast-Induced Acute Kidney Injury Through ROS\/NLRP3\/Caspase-1\/GSDMD\nPathway-Mediated Proptosis in vitro","volume":"16","author":"Li","year":"2022","journal-title":"Drug Des.\nDev. Ther."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c07405","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/31\/47148\/66285655\/acsomega.6c07405.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/31\/47148\/66285655\/acsomega.6c07405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:02:03Z","timestamp":1786460523000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/31\/47148\/5234283\/Folate-Targeted-Co-Delivery-of-Curcumin-and-siRela"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":46,"journal-issue":{"issue":"31","published-online":{"date-parts":[[2026,7,27]]},"published-print":{"date-parts":[[2026,8,11]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c07405","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]}}}