{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:01:26Z","timestamp":1790096486843,"version":"4.0.1"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"publisher","award":["IDROL 20056"],"award-info":[{"award-number":["IDROL 20056"]}],"id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"publisher","award":["Practice 2017.0524"],"award-info":[{"award-number":["Practice 2017.0524"]}],"id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["266 PNC-HLS-DA"],"award-info":[{"award-number":["266 PNC-HLS-DA"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["683"],"award-info":[{"award-number":["683"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["PNC-E3-2022-23"],"award-info":[{"award-number":["PNC-E3-2022-23"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>STAT3 (Signal Transducer and Activator of Transcription 3) is a protein frequently hyperactivated in a wide range of tumors, and as such, it has emerged as a promising and relatively recent therapeutic target for the development of novel anticancer agents. In this framework, we have designed and synthesized a new family of STAT3 inhibitors using a diversity-oriented strategy centered on the Ugi multicomponent reaction, enabling rapid access to structurally varied molecular scaffolds. We subsequently evaluated their antiproliferative activity across eight different tumor cell lines, revealing that four of the 23 newly obtained compounds exhibit pharmacologically meaningful growth-inhibitory effects within the micromolar range of concentrations and displayed promising drug-like profiles. Taken together, these findings highlight the potential of our approach to generate effective STAT3-modulating chemotypes and underscore the value of multicomponent reactions in accelerating early-stage anticancer drug discovery.<\/jats:p>","DOI":"10.1021\/acsomega.6c07733","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:02:09Z","timestamp":1788991329000},"page":"56468-56491","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Biological\nEvaluation of a New Family\nof STAT3 Inhibitors by a Diversity Oriented Approach Based on the\nUgi-Multicomponent Reaction"],"prefix":"10.1021","volume":"11","author":[{"given":"Chiara","family":"Lambruschini","sequence":"first","affiliation":[{"name":"Universita\u0300 di Genova , , Via Dodecaneso 31 , ,","place":["Genova, Italy, 16146"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Anselmo","sequence":"additional","affiliation":[{"name":"Universita\u0300 di Genova , , Via Dodecaneso 31 , ,","place":["Genova, Italy, 16146"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-0993","authenticated-orcid":true,"given":"Luca","family":"Banfi","sequence":"additional","affiliation":[{"name":"Universita\u0300 di Genova , , Via Dodecaneso 31 , ,","place":["Genova, Italy, 16146"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-3260","authenticated-orcid":true,"given":"Nadia","family":"Bertola","sequence":"additional","affiliation":[{"name":"AOM-IRCCS Ospedale Policlinico San Martino, U.O.C. Bioterapie , Largo R. Benzi 10 , ,","place":["Genova, Italy, 16132"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Carbotti","sequence":"additional","affiliation":[{"name":"AOM-IRCCS Ospedale Policlinico San Martino, U.O.C. Bioterapie , Largo R. Benzi 10 , ,","place":["Genova, Italy, 16132"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3402-8170","authenticated-orcid":true,"given":"Maria Maddalena","family":"Cavalluzzi","sequence":"additional","affiliation":[{"name":"Universita\u0300 degli Studi di Bari Aldo Moro , , Via Orabona 4 , ,","place":["Bari, Italy, 70125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-5994","authenticated-orcid":true,"given":"Giovanni","family":"Lentini","sequence":"additional","affiliation":[{"name":"Universita\u0300 degli Studi di Bari Aldo Moro , , Via Orabona 4 , ,","place":["Bari, Italy, 70125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9461-1963","authenticated-orcid":true,"given":"Valeria Marisa","family":"Rocca","sequence":"additional","affiliation":[{"name":"Universita\u0300 di Genova , , Via Dodecaneso 31 , ,","place":["Genova, Italy, 16146"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camillo","family":"Rosano","sequence":"additional","affiliation":[{"name":"U.O.S. Proteomica e Spettrometria di Massa , , Largo R. Benzi 10 , ,","place":["Genova, Italy, 16132"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Viale","sequence":"additional","affiliation":[{"name":"AOM-IRCCS Ospedale Policlinico San Martino, U.O.C. Bioterapie , Largo R. Benzi 10 , ,","place":["Genova, Italy, 16132"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-9444","authenticated-orcid":true,"given":"Renata","family":"Riva","sequence":"additional","affiliation":[{"name":"Universita\u0300 di Genova , , Via Dodecaneso 31 , ,","place":["Genova, Italy, 16146"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"issue":"3","key":"2026092211033321800_cit1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN\nestimates of incidence and mortality worldwide for 36 cancers in 185\ncountries","volume":"74","author":"Bray","year":"2024","journal-title":"Ca-Cancer J. Clin."},{"issue":"10","key":"2026092211033321800_cit2","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/nrc906","article-title":"Transcription\nfactors as targets for cancer therapy","volume":"2","author":"Darnell","year":"2002","journal-title":"Nat.\nRev. Cancer"},{"issue":"2","key":"2026092211033321800_cit3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nrc1275","article-title":"The STATs of cancer\u2500new molecular targets come of age","volume":"4","author":"Yu","year":"2004","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"2026092211033321800_cit4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0092-8674(00)81959-5","article-title":"Stat3 as an Oncogene","volume":"98","author":"Bromberg","year":"1999","journal-title":"Cell"},{"issue":"1","key":"2026092211033321800_cit5","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-4-2","article-title":"Stable\nexpression of constitutively-activated STAT3 in benign prostatic epithelial\ncells changes their phenotype to that resembling malignant cells","volume":"4","author":"Huang","year":"2005","journal-title":"Mol. Cancer"},{"issue":"13","key":"2026092211033321800_cit6","doi-asserted-by":"publisher","first-page":"8884","DOI":"10.1021\/acs.jmedchem.1c00629","article-title":"Recent Update on\nDevelopment of Small-Molecule STAT3 Inhibitors for Cancer Therapy:\nFrom Phosphorylation Inhibition to Protein Degradation","volume":"64","author":"Dong","year":"2021","journal-title":"J. Med. Chem."},{"issue":"7","key":"2026092211033321800_cit7","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1080\/13543776.2025.2494857","article-title":"Novel inhibitors\nof STAT3: an updated patent review\n(2022\u2013present)","volume":"35","author":"Bao","year":"2025","journal-title":"Expert Opin. Ther. Pat."},{"key":"2026092211033321800_cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111922","article-title":"Revisiting\nsignal transducer and activator of transcription 3 (STAT3) as an anticancer\ntarget and its inhibitor discovery: Where are we and where should\nwe go?","volume":"187","author":"Huang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"2026092211033321800_cit9","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1124\/pr.119.018440","article-title":"Targeting Janus\nKinases and Signal Transducer and Activator of Transcription 3 To\nTreat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and\nCaution","volume":"72","author":"Bharadwaj","year":"2020","journal-title":"Pharmacol. Rev."},{"issue":"6","key":"2026092211033321800_cit10","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1080\/13543776.2022.2056013","article-title":"Novel inhibitors\nof the STAT3 signaling pathway: an updated patent review (2014-present)","volume":"32","author":"Wang","year":"2022","journal-title":"Expert Opin. Ther. Pat."},{"issue":"3","key":"2026092211033321800_cit11","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1080\/13543784.2021.1891222","article-title":"An update on investigational therapies\nthat target\nSTAT3 for the treatment of cancer","volume":"30","author":"Santoni","year":"2021","journal-title":"Expert Opin.\nInvest. Drugs"},{"issue":"1","key":"2026092211033321800_cit12","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00280-014-2480-2","article-title":"Phase 1, open-label, dose-escalation,\nand pharmacokinetic\nstudy of STAT3 inhibitor OPB-31121 in subjects with advanced solid\ntumors","volume":"74","author":"Bendell","year":"2014","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"5","key":"2026092211033321800_cit13","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1001\/jamaoncol.2015.1591","article-title":"JAK\/STAT Pathway Inhibitors and Neurologic Toxicity:\nAbove All Else Do No Harm?","volume":"1","author":"Scott","year":"2015","journal-title":"JAMA Oncol."},{"key":"2026092211033321800_cit14","unstructured":"Viale, M.; Riva, R.; Lambruschini, C.\n          Non-covalent Stat3 inhibitor\nantitumor agent N. PCT\/IB2026\/054067 Priority number: IT - Nr. 102025000009258\n2025\u201304\u201324."},{"issue":"1","key":"2026092211033321800_cit15","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/anie.200300626","article-title":"A Planning Strategy for Diversity-Oriented Synthesis","volume":"43","author":"Burke","year":"2004","journal-title":"Angew. Chem., Int. Ed."},{"issue":"3","key":"2026092211033321800_cit16","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.cbpa.2008.02.004","article-title":"Isocyanide-based\nmulticomponent reactions in drug discovery","volume":"12","author":"Akritopoulou-Zanze","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"5","key":"2026092211033321800_cit17","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1002\/tcr.201500201","article-title":"Multicomponent Reactions, Union of\nMCRs and Beyond","volume":"15","author":"Zarganes-Tzitzikas","year":"2015","journal-title":"Chem. Rec."},{"issue":"17","key":"2026092211033321800_cit18","doi-asserted-by":"publisher","first-page":"10742","DOI":"10.1021\/acs.chemrev.1c00143","article-title":"Medicinal Chemistry of Isocyanides","volume":"121","author":"Massarotti","year":"2021","journal-title":"Chem. Rev."},{"issue":"41","key":"2026092211033321800_cit19","doi-asserted-by":"publisher","first-page":"47714","DOI":"10.1021\/acsomega.5c06428","article-title":"Ugi and Groebke\u2013Blackburn\u2013Bienayme\u0301\nReactions in Medicinal Chemistry: An Outlook on New Bioactive Compounds","volume":"10","author":"Barbosa-Reis","year":"2025","journal-title":"ACS Omega"},{"issue":"44","key":"2026092211033321800_cit20","doi-asserted-by":"publisher","first-page":"9331","DOI":"10.1039\/C7OB02182H","article-title":"Multicomponent,\nfragment-based synthesis of polyphenol-containing peptidomimetics\nand their inhibiting activity on beta-amyloid oligomerization","volume":"15","author":"Lambruschini","year":"2017","journal-title":"Org. Biomol. Chem."},{"issue":"14","key":"2026092211033321800_cit21","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24142636","article-title":"Multicomponent\nSynthesis of Polyphenols and Their In Vitro Evaluation as Potential\n\u03b2-Amyloid Aggregation Inhibitors","volume":"24","author":"Galante","year":"2019","journal-title":"Molecules"},{"issue":"7","key":"2026092211033321800_cit22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076581","article-title":"Multicomponent Reaction-Assisted\nDrug Discovery: A Time- and Cost-Effective Green Approach Speeding\nUp Identification and Optimization of Anticancer Drugs","volume":"24","author":"Graziano","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2026092211033321800_cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117377","article-title":"Discovery\nof naphthoquinone-furo-piperidone\nderivatives as dual targeting agents of STAT3 and NQO1 for the treatment\nof breast cancer","volume":"287","author":"Lou","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"2026092211033321800_cit24","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1039\/B918763B","article-title":"Green Chemistry: Principles\nand Practice","volume":"39","author":"Anastas","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"2026092211033321800_cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.tgchem.2024.100044","article-title":"The Ugi\nreaction as the green alternative towards active pharmaceutical ingredients","volume":"3","author":"Fotopoulou","year":"2024","journal-title":"Tetrahedron Green Chem."},{"issue":"11","key":"2026092211033321800_cit26","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.chembiol.2006.09.018","article-title":"Stattic: A\nSmall-Molecule Inhibitor of STAT3 Activation and Dimerization","volume":"13","author":"Schust","year":"2006","journal-title":"Chem. Biol."},{"issue":"12","key":"2026092211033321800_cit27","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1002\/cbic.200900172","article-title":"Disruption of Transcriptionally\nActive\nStat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules:\nPotent in vitro and Tumor Cell Activities","volume":"10","author":"Fletcher","year":"2009","journal-title":"ChemBioChem"},{"issue":"8","key":"2026092211033321800_cit28","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1002\/cmdc.201100194","article-title":"Antagonism of the\nStat3\u2013Stat3 Protein Dimer with Salicylic Acid Based Small Molecules","volume":"6","author":"Fletcher","year":"2011","journal-title":"ChemMedChem"},{"issue":"1","key":"2026092211033321800_cit29","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/ejoc.201001077","article-title":"Tandem Ugi MCR\/Mitsunobu\nCyclization as a Short, Protecting-Group-Free\nRoute to Benzoxazinones with Four Diversity Points","volume":"2011","author":"Banfi","year":"2011","journal-title":"Eur. J. Org. Chem."},{"issue":"3","key":"2026092211033321800_cit30","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1039\/C9GC04070F","article-title":"A more\nsustainable and highly practicable synthesis of aliphatic isocyanides","volume":"22","author":"Waibel","year":"2020","journal-title":"Green Chem."},{"issue":"18","key":"2026092211033321800_cit31","doi-asserted-by":"publisher","first-page":"7022","DOI":"10.1039\/D2GC01398C","article-title":"In-water synthesis of isocyanides under micellar conditions","volume":"24","author":"Brunelli","year":"2022","journal-title":"Green Chem."},{"key":"2026092211033321800_cit32","doi-asserted-by":"publisher","first-page":"732","DOI":"10.3762\/bjoc.18.73","article-title":"A trustworthy\nmechanochemical route to isocyanides","volume":"18","author":"Basoccu","year":"2022","journal-title":"Beilstein\nJ. Org. Chem."},{"issue":"10","key":"2026092211033321800_cit33","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.2174\/138955707782110150","article-title":"alpha-Fluorinated\nEthers as \u2033Exotic\u2033\nEntity in Medicinal Chemistry","volume":"7","author":"Jeschke","year":"2007","journal-title":"Mini-Rev. Med.\nChem."},{"issue":"48","key":"2026092211033321800_cit34","doi-asserted-by":"publisher","first-page":"7961","DOI":"10.1002\/anie.200502636","article-title":"Phenol Ugi\u2013Smiles\nSystems: Strategies for the Multicomponent N-Arylation of Primary\nAmines with Isocyanides, Aldehydes, and Phenols","volume":"44","author":"El Kai\u0308m","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"issue":"4","key":"2026092211033321800_cit35","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13040772","article-title":"Sulfonamides a Promising\nHit for Cancer Therapy Through\nVEGFR-2 Inhibition","volume":"13","author":"Charissopoulos","year":"2025","journal-title":"Biomedicines"},{"issue":"11","key":"2026092211033321800_cit36","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.1016\/S0968-0896(02)00239-0","article-title":"5-Substituted-1H-tetrazoles\nas carboxylic acid isosteres: medicinal chemistry and synthetic methods","volume":"10","author":"Herr","year":"2002","journal-title":"Bioorg. Med. Chem."},{"issue":"7","key":"2026092211033321800_cit37","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1021\/jo00007a027","article-title":"III. Three\nsynthetic routes to a\nsterically hindered tetrazole. A new one-step mild conversion of an\namide into a tetrazole","volume":"56","author":"Duncia","year":"1991","journal-title":"J. Org. Chem."},{"key":"2026092211033321800_cit38","first-page":"487","volume-title":"Bretherick\u2019s Handbook\nof Reactive Chemical Hazards","author":"Urben","year":"2008","edition":"7"},{"issue":"12","key":"2026092211033321800_cit39","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1002\/chem.200501326","article-title":"The Interplay of Inverted Redox Potentials and Aromaticity\nin the Oxidized States of New \u03c0-Electron Donors: 9-(1,3-Dithiol-2-ylidene)fluorene\nand 9-(1,3-Dithiol-2-ylidene)thioxanthene Derivatives","volume":"12","author":"Amriou","year":"2006","journal-title":"Chem. - Eur. J."},{"issue":"11","key":"2026092211033321800_cit40","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1080\/17460441.2017.1365056","article-title":"Ligand efficiency metrics\nin drug discovery: the pros and cons from a practical perspective","volume":"12","author":"Cavalluzzi","year":"2017","journal-title":"Expert Opin. Drug Discovery"},{"issue":"7","key":"2026092211033321800_cit41","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1080\/17460441.2021.1884065","article-title":"Ligand efficiency\nindices for effective drug discovery: a unifying vector formulation","volume":"16","author":"Abad-Zapatero","year":"2021","journal-title":"Expert Opin. Drug Discovery"},{"issue":"20","key":"2026092211033321800_cit42","doi-asserted-by":"publisher","first-page":"7704","DOI":"10.1021\/ja2026882","article-title":"Total Synthesis of\n(\u00b1)-Cycloclavine and (\u00b1)-5-epi-Cycloclavine","volume":"133","author":"Petronijevic","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"17","key":"2026092211033321800_cit43","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1021\/jm980617f","article-title":"Structural\nModification of Fas C-Terminal Tripeptide and Its Effects on the Inhibitory\nActivity of Fas\/FAP-1 Binding","volume":"42","author":"Sawa","year":"1999","journal-title":"J. Med. Chem."},{"key":"2026092211033321800_cit44","doi-asserted-by":"publisher","first-page":"68803","DOI":"10.18632\/oncotarget.11931","article-title":"A highly invasive subpopulation\nof MDA-MB-231 breast\ncancer cells shows accelerated growth, differential chemoresistance,\nfeatures of apocrine tumors and reduced tumorigenicity in vivo","volume":"7","author":"Amaro","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"2026092211033321800_cit45","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0022-1759(93)90012-V","article-title":"A new approach\nfor measurement of\ncytotoxicity using colorimetric assay","volume":"160","author":"Hussain","year":"1993","journal-title":"J. Immunol.\nMethods"},{"issue":"6","key":"2026092211033321800_cit46","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The\nPhyre2 web portal for protein modeling, prediction and analysis","volume":"10","author":"Kelley","year":"2015","journal-title":"Nat. Protoc."},{"issue":"1","key":"2026092211033321800_cit47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/(sici)1099-1352(199601)9:13.0.co;2-6","article-title":"Automated docking of flexible ligands:\nApplications of autodock","volume":"9","author":"Goodsell","year":"1996","journal-title":"J. Mol. Recognit."},{"key":"2026092211033321800_cit48","unstructured":"Sanner, M. F.; Duncan, B. S.; Carrillo, C. J.; Olson, A. J. In  Integrating Computation\nand Visualization for Biomolecular Analysis: An Example Using Python\nand AVS; Biocomputing \u201899, World Scientific\nPublishing, 1999; pp 401\u201341210.1002\/(SICI)1099-1352(199601)9:1&lt;1:AID-JMR241&gt;3.0.CO;2-6."},{"issue":"13","key":"2026092211033321800_cit49","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2500A\nvisualization\nsystem for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c07733","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/37\/56468\/68466126\/acsomega.6c07733.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/37\/56468\/68466126\/acsomega.6c07733.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:03:52Z","timestamp":1790093032000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/37\/56468\/5427374\/Synthesis-and-Biological-Evaluation-of-a-New"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":49,"journal-issue":{"issue":"37","published-online":{"date-parts":[[2026,9,9]]},"published-print":{"date-parts":[[2026,9,22]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c07733","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]}}}