{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:51:46Z","timestamp":1789487506324,"version":"build-2803163510"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Poly(L-lactic acid)\/hydroxyapatite (PLLA\/HAp) composites have attracted significant attention as environmentally friendly tough materials due to their excellent biocompatibility and mechanical strength. However, the poor organic\u2013inorganic interfacial adhesion between PLLA and HAp has been a significant challenge, often resulting in the premature elution of PLLA and a reduction in the mechanical integrity. Here, we prepared PLLA\/HAp composites with a controllable interface by using etidronic acid, a bisphosphonate compound, as an interface modifier for HAp. Etidronic acid modification of HAp increased the bending strength of PLLA\/E-HAp composites up to 66.7 MPa and improved the stability in phosphate buffer saline solution due to grafting of PLLA chains onto the HAp surface. The interface strengthened by chelation between etidronic acid and Ca in HAp could be dissociated in hydrochloric acid, resulting in the successful separation of PLLA and HAp.<\/jats:p>","DOI":"10.1021\/acsomega.6c07823","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:20:12Z","timestamp":1788459612000},"page":"54697-54703","source":"Crossref","is-referenced-by-count":0,"title":["Interface Control\nof Poly(L-lactic Acid)\/Hydroxyapatite\nComposites by Using Bisphosphonate"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9248-0286","authenticated-orcid":true,"given":"Rin","family":"Ito","sequence":"first","affiliation":[{"name":"Sophia University , , 7-1 Kioi-cho , , ,","place":["Chiyoda-ku, Tokyo, Japan, 102-8554"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Sophia University , , 7-1 Kioi-cho , , ,","place":["Chiyoda-ku, Tokyo, Japan, 102-8554"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Meiji University , , 1-1-1 Higashimita , , ,","place":["Tama-ku, Kawasaki, Japan, 214-8571"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8269-985X","authenticated-orcid":true,"given":"Masahiro","family":"Yoshizawa-Fujita","sequence":"additional","affiliation":[{"name":"Sophia University , , 7-1 Kioi-cho , , ,","place":["Chiyoda-ku, Tokyo, Japan, 102-8554"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-1072","authenticated-orcid":true,"given":"Masahiro","family":"Rikukawa","sequence":"additional","affiliation":[{"name":"Sophia University , , 7-1 Kioi-cho , , ,","place":["Chiyoda-ku, Tokyo, Japan, 102-8554"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4958-3879","authenticated-orcid":true,"given":"Yuko","family":"Takeoka","sequence":"additional","affiliation":[{"name":"Sophia University , , 7-1 Kioi-cho , , ,","place":["Chiyoda-ku, Tokyo, Japan, 102-8554"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"2026091510084253600_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14050976","article-title":"Advances of Hydroxyapatite\nHybrid Organic Composite Used as Drug or Protein Carriers for Biomedical\nApplications: A Review","volume":"14","author":"Huang","year":"2022","journal-title":"Polymers"},{"key":"2026091510084253600_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2023.103013","article-title":"Hydroxyapatite: A Journey\nfrom Biomaterials to Advanced Functional Materials","volume":"321","author":"Mondal","year":"2023","journal-title":"Adv. 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Res."},{"key":"2026091510084253600_cit21","doi-asserted-by":"publisher","first-page":"4379","DOI":"10.1002\/pola.24878","article-title":"Controlled\nSurface-Initiated Ring-opening Polymerization of L-lactide from Risedronate-anchored\nHydroxyapatite Nanocrystals: Novel Synthesis of Biodegradable Hydroxyapatite\/poly(L-lactide)\nNanocomposites","volume":"49","author":"Chen","year":"2011","journal-title":"J. Polym. Sci., Part A:Polym.\nChem."},{"issue":"2","key":"2026091510084253600_cit22","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1021\/ie504181z","article-title":"Modification\nof Hydroxyapatite with Ion-Selective Complexants: 1-Hydroxyethane-1,1-diphosphonic\nAcid","volume":"54","author":"Daniels","year":"2015","journal-title":"Ind. Eng. Chem. 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Med."},{"key":"2026091510084253600_cit26","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.bone.2005.05.003","article-title":"Novel Insights into\nActions of Bisphosphonates on Bone: Differences in Interactions with\nHydroxyapatite","volume":"38","author":"Nancollas","year":"2006","journal-title":"Bone"},{"key":"2026091510084253600_cit27","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jct.2013.07.005","article-title":"Thermodynamics of HEDPA Protonation\nin Different Media and Complex Formation with Mg2+ and\nCa2+","volume":"66","author":"Foti","year":"2013","journal-title":"J. Chem. Thermodyn."},{"key":"2026091510084253600_cit28","doi-asserted-by":"publisher","DOI":"10.1039\/D3RA03052K","article-title":"Molecular\nStructures of 1-hydroxyethane-1,1-diphosphonic Acid for Removing Calcium\nSulfate Scale under Different pH Conditions","volume":"13","author":"Zhao","year":"2023","journal-title":"RSC Adv."},{"key":"2026091510084253600_cit29","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2109\/jcersj.108.1255_249","article-title":"Fabrication\nof Porous Ceramics with\nWell-controlled Open Pores by Sintering of Fibrous Hydroxyapatite\nParticles","volume":"108","author":"Aizawa","year":"2000","journal-title":"J. Ceram. Soc. Jpn."},{"key":"2026091510084253600_cit30","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.1016\/j.biomaterials.2004.09.044","article-title":"Ultrastructural Observation\nof Single-crystal Apatite Fibres","volume":"26","author":"Aizawa","year":"2005","journal-title":"Biomaterials"},{"issue":"2","key":"2026091510084253600_cit31","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.saa.2007.07.043","article-title":"An ATR-FTIR Study\nof Different Phosphonic Acids in Aqueous Solution","volume":"70","author":"Zenobi","year":"2008","journal-title":"Spectrochim. Acta, Part A"},{"key":"2026091510084253600_cit32","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28114469","article-title":"Europium(III)\nMeets Etidronic Acid\n(HEDP): A Coordination Study Combining Spectroscopic, Spectrometric,\nand Quantum Chemical Methods","volume":"28","author":"Heller","year":"2023","journal-title":"Molecules"},{"key":"2026091510084253600_cit33","doi-asserted-by":"publisher","DOI":"10.1021\/ie501569d","article-title":"Study on Acidizing\nEffect of Cationic \u03b2-Cyclodextrin Inclusion Complex with Sandstone\nfor Enhancing Oil Recovery","volume":"53","author":"Zou","year":"2014","journal-title":"Ind. Eng. Chem.\nRes."},{"key":"2026091510084253600_cit34","doi-asserted-by":"publisher","first-page":"5231","DOI":"10.1021\/la9603277","article-title":"Effect of Precipitating\nConditions on the Formation\nof calcium\u2013HEDP Precipitates","volume":"12","author":"Browning","year":"1996","journal-title":"Langmuir"},{"key":"2026091510084253600_cit35","doi-asserted-by":"publisher","first-page":"7674","DOI":"10.1021\/acs.jpcb.5c03972","article-title":"Novel and Efficient\nOrganic Phosphonic Acid Inhibitor to Achieve\nthe Flotation Separation of Apatite and Dolomite","volume":"129","author":"Lan","year":"2025","journal-title":"J. Phys. Chem. B"},{"key":"2026091510084253600_cit36","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1016\/j.apsusc.2006.05.031","article-title":"XPS and Bioactivity\nStudy of the\nBisphosphonate Pamidronate Adsorbed onto Plasma Sprayed Hydroxyapatite\nCoatings","volume":"253","author":"McLeod","year":"2006","journal-title":"Appl. Surf. Sci."},{"issue":"7","key":"2026091510084253600_cit37","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/S0021-9290(03)00071-X","article-title":"Trabecular Bone Modulus\u2013density\nRelationships Depend on Anatomic Site","volume":"36","author":"Morgan","year":"2003","journal-title":"J. Biomech."},{"key":"2026091510084253600_cit38","doi-asserted-by":"publisher","DOI":"10.1002\/macp.202100464","article-title":"SnOct2-catalyzed and alcohol-initiated\nROPS of L-lactide\u2500Control of the Molecular Weight and the Role\nof Cyclization","volume":"223","author":"Kricheldorf","year":"2022","journal-title":"Macromol. Chem. 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