{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:26:46Z","timestamp":1792603606969,"version":"4.5.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","award":["GSA22P001"],"award-info":[{"award-number":["GSA22P001"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit? e della Ricerca","doi-asserted-by":"publisher","award":["PE0000006"],"award-info":[{"award-number":["PE0000006"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["2022N9E847  B53D23015580006"],"award-info":[{"award-number":["2022N9E847  B53D23015580006"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Associazione Italiana Gaucher","award":["GSA22P001"],"award-info":[{"award-number":["GSA22P001"]}]},{"name":"AMMeC ONLUS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gaucher disease and Parkinson\u2019s disease are characterized by \u03b2-glucocerebrosidase (GCase) dysfunction and increased oxidative stress. Here, we report two multifunctional hybrids that combine an iminosugar-based pharmacological chaperone scaffold with curcumin- or ferulic acid-derived antioxidant motifs. The curcumin-iminosugar hybrid 2 exhibits pH-dependent GCase modulation, enhanced GCase activity under lysosomal conditions, enhanced enzyme activity in L444P Gaucher and wild-type fibroblasts, and reduced intracellular reactive oxygen species (ROS) levels. By integrating GCase enhancement and redox modulation within a single molecular framework, compound 2 represents a promising lead for Gaucher disease and GCase-related synucleinopathies.<\/jats:p>","DOI":"10.1021\/acsomega.6c08401","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:01:34Z","timestamp":1790877694000},"page":"62107-62114","source":"Crossref","is-referenced-by-count":1,"title":["A pH-Dependent\nCurcumin\u2013Iminosugar Hybrid Promotes\nGCase Enhancement and Reactive Oxygen Species Reduction"],"prefix":"10.1021","volume":"11","author":[{"given":"Alessio","family":"Morano","sequence":"first","affiliation":[{"name":"University of Florence , , Via della Lastruccia 3\u221213 , ,","place":["Sesto F.no (FI), Italy, 50019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8336-383X","authenticated-orcid":true,"given":"Camilla","family":"Matassini","sequence":"additional","affiliation":[{"name":"University of Florence , , Via della Lastruccia 3\u221213 , ,","place":["Sesto F.no (FI), Italy, 50019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6766-4624","authenticated-orcid":true,"given":"Francesca","family":"Cardona","sequence":"additional","affiliation":[{"name":"University of Florence , , Via della Lastruccia 3\u221213 , ,","place":["Sesto F.no (FI), Italy, 50019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8930-3566","authenticated-orcid":true,"given":"Damiano","family":"Tanini","sequence":"additional","affiliation":[{"name":"University of Florence , , Via della Lastruccia 3\u221213 , ,","place":["Sesto F.no (FI), Italy, 50019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Falliano","sequence":"additional","affiliation":[{"name":"Meyer Children\u2019s Hospital IRCCS , , Viale Pieraccini 24 , ,","place":["Firenze, Italy, 50139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2890-8179","authenticated-orcid":true,"given":"Amelia","family":"Morrone","sequence":"additional","affiliation":[{"name":"Meyer Children\u2019s Hospital IRCCS , , Viale Pieraccini 24 , ,","place":["Firenze, Italy, 50139"]},{"name":"University of Florence , , Viale Pieraccini 24 , ,","place":["Firenze, Italy, 50139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7819-1796","authenticated-orcid":true,"given":"Rebecca","family":"Sodano","sequence":"additional","affiliation":[{"name":"University of Florence , , Viale Morgagni 50 ,","place":["Firenze, Italy, 50134"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6448-7266","authenticated-orcid":true,"given":"Paolo","family":"Paoli","sequence":"additional","affiliation":[{"name":"University of Florence , , Viale Morgagni 50 ,","place":["Firenze, Italy, 50134"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1081-533X","authenticated-orcid":true,"given":"Andrea","family":"Goti","sequence":"additional","affiliation":[{"name":"University of Florence , , Via della Lastruccia 3\u221213 , ,","place":["Sesto F.no (FI), Italy, 50019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-0836","authenticated-orcid":true,"given":"Francesca","family":"Clemente","sequence":"additional","affiliation":[{"name":"University of Florence , , Via della Lastruccia 3\u221213 , ,","place":["Sesto F.no (FI), Italy, 50019"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026101315064990700_cit1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s10787-016-0264-5","article-title":"The Antioxidant Activity of Some Curcuminoids and Chalcones","volume":"24","author":"So\u0308kmen","year":"2016","journal-title":"Inflammopharmacology"},{"key":"2026101315064990700_cit2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216711","article-title":"Curcumin Attenuates\nOxidative Stress in RAW264.7 Cells by Increasing\nthe Activity of Antioxidant Enzymes and Activating the Nrf2-Keap1\nPathway","volume":"14","author":"Lin","year":"2019","journal-title":"PLoS One"},{"key":"2026101315064990700_cit3","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.3390\/antiox12091725","article-title":"Dual Action\nof Curcumin as an Anti- and Pro-Oxidant\nfrom a Biophysical Perspective","volume":"12","author":"Wolnicka-Glubisz","year":"2023","journal-title":"Antioxidants"},{"key":"2026101315064990700_cit4","doi-asserted-by":"publisher","first-page":"1548073","DOI":"10.3389\/fphar.2025.1548073","article-title":"Research Progress on\nthe Mechanism of Curcumin Anti-Oxidative Stress\nBased on Signaling Pathway","volume":"16","author":"Cui","year":"2025","journal-title":"Front. Pharmacol."},{"key":"2026101315064990700_cit5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3390\/jox15050139","article-title":"Antioxidant\nEffect of Curcumin and Its Impact on Mitochondria:\nEvidence from Biological Models","volume":"15","author":"Avendan\u0303o-Brisen\u0303o","year":"2025","journal-title":"J. Xenobiot."},{"key":"2026101315064990700_cit6","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.3390\/pharmaceutics13122102","article-title":"Biomedical Applications and Bioavailability\nof Curcumin\u2500An Updated Overview","volume":"13","author":"Sohn","year":"2021","journal-title":"Pharmaceutics"},{"key":"2026101315064990700_cit7","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.3390\/foods13111774","article-title":"Neuroprotective\nEffects of Curcumin in Neurodegenerative Diseases","volume":"13","author":"Genchi","year":"2024","journal-title":"Foods"},{"key":"2026101315064990700_cit8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3390\/molecules30010043","article-title":"A Review\non Current Aspects of Curcumin-Based Effects\nin Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular\nDiseases","volume":"30","author":"Moldoveanu","year":"2025","journal-title":"Molecules"},{"key":"2026101315064990700_cit9","doi-asserted-by":"publisher","first-page":"1517174","DOI":"10.3389\/fphar.2025.1517174","article-title":"Exploring\nthe Role\nof Curcumin in Mitigating Oxidative Stress to Alleviate Lipid Metabolism\nDisorders","volume":"16","author":"Cheng","year":"2025","journal-title":"Front. Pharmacol."},{"key":"2026101315064990700_cit10","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.3390\/nu17172884","article-title":"The Neuroprotective\nRole of Curcumin: From Molecular Pathways to Clinical Translation\u2500A\nNarrative Review","volume":"17","author":"Lehoczki","year":"2025","journal-title":"Nutrients"},{"key":"2026101315064990700_cit11","doi-asserted-by":"publisher","first-page":"100890","DOI":"10.1016\/j.cophys.2025.100890","article-title":"Curcumin, Resveratrol, and Other Polyphenols in Regulating Redox\nImbalance in Inflammatory Bowel Disease","volume":"47","author":"Luo","year":"2026","journal-title":"Curr.\nOpin. Physiol."},{"key":"2026101315064990700_cit12","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1002\/cmdc.201600161","article-title":"Multitarget Drug Discovery and Polypharmacology","volume":"11","author":"Bolognesi","year":"2016","journal-title":"ChemMedChem"},{"key":"2026101315064990700_cit13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40169-017-0181-2","article-title":"A Perspective\non Multi-Target Drug Discovery and Design for Complex Diseases","volume":"7","author":"Ramsay","year":"2018","journal-title":"Clin. Transl. Med."},{"key":"2026101315064990700_cit14","doi-asserted-by":"crossref","DOI":"10.2217\/9781780842011","volume-title":"Advances in Gaucher\nDisease: Basic and Clinical Perspectives","author":"Grabowski","year":"2013"},{"key":"2026101315064990700_cit15","doi-asserted-by":"publisher","first-page":"2840","DOI":"10.3390\/diagnostics14242840","article-title":"An Overview of Gaucher Disease","volume":"14","author":"Me\u0301ndez-Cobia\u0301n","year":"2024","journal-title":"Diagnostics"},{"key":"2026101315064990700_cit16","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s12011-019-01709-3","article-title":"Oxidative Stress Parameters, Trace\nElements, and Lipid Profile in Iranian Patients with Gaucher Disease","volume":"193","author":"Mozafari","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"2026101315064990700_cit17","doi-asserted-by":"publisher","first-page":"100667","DOI":"10.1016\/j.ymgmr.2020.100667","article-title":"Patients with Gaucher Disease Display\nSystemic Oxidative\nStress Dependent on Therapy Status","volume":"25","author":"Kartha","year":"2020","journal-title":"Mol. Genet\nMetab. Rep."},{"key":"2026101315064990700_cit18","doi-asserted-by":"publisher","first-page":"9189","DOI":"10.3390\/ijms23169189","article-title":"Biological\nVariation in Peripheral Inflammation and Oxidative Stress Biomarkers\nin Individuals with Gaucher Disease","volume":"23","author":"Sahasrabudhe","year":"2022","journal-title":"Int. J.\nMol. Sci."},{"key":"2026101315064990700_cit19","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s00109-021-02174-z","article-title":"Gaucher Disease\u2500More\nthan Just a Rare Lipid Storage Disease","volume":"100","author":"Roh","year":"2022","journal-title":"J. Mol.\nMed."},{"key":"2026101315064990700_cit20","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.79830","article-title":"Neuroinflammation in Neuronopathic Gaucher Disease:\nRole of Microglia and NK Cells, Biomarkers, and Response to Substrate\nReduction Therapy","volume":"11","author":"Boddupalli","year":"2022","journal-title":"eLife"},{"key":"2026101315064990700_cit21","doi-asserted-by":"publisher","first-page":"16035","DOI":"10.3390\/ijms242216035","article-title":"Animal Models for the\nStudy of Gaucher Disease","volume":"24","author":"Cabasso","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2026101315064990700_cit22","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1021\/jm301557k","article-title":"Pharmacological\nChaperones as Therapeutics for Lysosomal\nStorage Diseases","volume":"56","author":"Boyd","year":"2013","journal-title":"J. Med. Chem."},{"key":"2026101315064990700_cit23","doi-asserted-by":"publisher","first-page":"5497","DOI":"10.1039\/C6CC01564F","article-title":"Glycomimetic-Based\nPharmacological Chaperones for Lysosomal Storage Disorders: Lessons\nfrom Gaucher, GM1-Gangliosidosis and Fabry Diseases","volume":"52","author":"Sa\u0301nchez-Ferna\u0301ndez","year":"2016","journal-title":"Chem. Commun."},{"key":"2026101315064990700_cit24","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3390\/ph15070823","article-title":"GCase Enhancers: A\nPotential Therapeutic Option for Gaucher Disease and Other Neurological\nDisorders","volume":"15","author":"Marti\u0301nez-Baile\u0301n","year":"2022","journal-title":"Pharmaceuticals"},{"key":"2026101315064990700_cit25","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3390\/cells11081261","article-title":"GBA Variants and Parkinson Disease: Mechanisms and\nTreatments","volume":"11","author":"Smith","year":"2022","journal-title":"Cells"},{"key":"2026101315064990700_cit26","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.3390\/genes15121605","article-title":"A Global Perspective of GBA1-Related Parkinson\u2019s\nDisease: A Narrative Review","volume":"15","author":"Koros","year":"2024","journal-title":"Genes"},{"key":"2026101315064990700_cit27","doi-asserted-by":"publisher","first-page":"1671760","DOI":"10.3389\/fnagi.2025.1671760","article-title":"Effects of Glucocerebrosidase Gene\nVariations on the Risk of Parkinson\u2019s Disease Dementia: A Meta-Analysis","volume":"17","author":"Li","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"2026101315064990700_cit28","doi-asserted-by":"publisher","first-page":"105663","DOI":"10.1016\/j.nbd.2022.105663","article-title":"Glucocerebrosidase-Associated Parkinson\nDisease: Pathogenic Mechanisms and Potential Drug Treatments","volume":"166","author":"Gegg","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"2026101315064990700_cit29","doi-asserted-by":"publisher","first-page":"168023","DOI":"10.1016\/j.jmb.2023.168023","article-title":"Mechanisms of Glucocerebrosidase Dysfunction in Parkinson\u2019s\nDisease","volume":"435","author":"Chatterjee","year":"2023","journal-title":"J. Mol. Biol."},{"key":"2026101315064990700_cit30","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm6393","article-title":"Mutant Glucocerebrosidase\nImpairs \u03b1-Synuclein Degradation by Blockade of Chaperone-Mediated\nAutophagy","volume":"8","author":"Kuo","year":"2022","journal-title":"Sci. Adv."},{"key":"2026101315064990700_cit31","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41582-024-00999-z","article-title":"Gaucher Disease Provides a Unique\nWindow into Parkinson Disease Pathogenesis","volume":"20","author":"Hertz","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"2026101315064990700_cit32","doi-asserted-by":"publisher","first-page":"118453","DOI":"10.1016\/j.bmc.2025.118453","article-title":"Selenoureido-N-alkyl-3,4,5-trihydroxypiperidines:\nProbing Their Dual-Target Role in Gaucher Disease","volume":"132","author":"Pratesi","year":"2026","journal-title":"Bioorg. Med. Chem."},{"key":"2026101315064990700_cit33","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1021\/acschemneuro.4c00618","article-title":"Evidence of \u03b1-Synuclein\/Glucocerebrosidase\nDual Targeting by Iminosugar Derivatives: New Insights for Addressing\nParkinson\u2019s Disease","volume":"16","author":"Tagliaferro","year":"2025","journal-title":"ACS Chem. Neurosci."},{"key":"2026101315064990700_cit34","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202200077","article-title":"3,4,5-Trihydroxypiperidine-Based\nMultivalent Glucocerebrosidase (GCase) Enhancers","volume":"23","author":"Vanni","year":"2022","journal-title":"ChemBioChem"},{"key":"2026101315064990700_cit35","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1021\/acs.bioconjchem.4c00496","article-title":"Multivalent\nGCase Enhancers: Synthesis and Evaluation of Glyco-Gold Nanoparticles\nDecorated with Trihydroxypiperidine Iminosugars","volume":"36","author":"Buco","year":"2025","journal-title":"Bioconjugate Chem."},{"key":"2026101315064990700_cit36","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.68063","article-title":"Ferulic Acid:\nA Comprehensive Review","volume":"16","author":"Purushothaman","year":"2024","journal-title":"Cureus"},{"key":"2026101315064990700_cit37","doi-asserted-by":"publisher","first-page":"853","DOI":"10.3390\/antiox13070853","article-title":"The Antioxidant\nProperties, Metabolism, Application and Mechanism of Ferulic Acid\nin Medicine, Food, Cosmetics, Livestock and Poultry","volume":"13","author":"Zheng","year":"2024","journal-title":"Antioxidants"},{"key":"2026101315064990700_cit38","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.3390\/molecules25133066","article-title":"Curcumin-1,2,3-Triazole Conjugation\nfor Targeting the\nCancer Apoptosis Machinery","volume":"25","author":"Seghetti","year":"2020","journal-title":"Molecules"},{"key":"2026101315064990700_cit39","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1002\/cbic.201500292","article-title":"Human Acid\n\u03b2-Glucosidase Inhibition by Carbohydrate-Derived Iminosugars:\nTowards New Pharmacological Chaperones for Gaucher Disease","volume":"16","author":"Parmeggiani","year":"2015","journal-title":"ChemBioChem"},{"key":"2026101315064990700_cit40","unstructured":"Skerlj, R. T.; Lansbury, P. T.; Bourque, E. M. J.; Good, A. C.\n          Methods of Treatment\nand Combination Therapies Using GCase Activator Heterobicyclic and\nRelated Compounds; WO 2017192841 A1. 2017."},{"key":"2026101315064990700_cit41","doi-asserted-by":"publisher","first-page":"5914","DOI":"10.1021\/jacs.7b13003","article-title":"\u03b2-Glucocerebrosidase\nModulators Promote Dimerization of \u03b2-Glucocerebrosidase and\nReveal an Allosteric Binding Site","volume":"140","author":"Zheng","year":"2018","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026101315064990700_cit42","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1021\/acs.jmedchem.8b01294","article-title":"Conversion\nof Quinazoline Modulators from Inhibitors to Activators of \u03b2-Glucocerebrosidase","volume":"62","author":"Zheng","year":"2019","journal-title":"J. Med. Chem."},{"key":"2026101315064990700_cit43","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202300548","article-title":"Identification of\n\u03b2-Glucocerebrosidase Activators for Glucosylceramide Hydrolysis","volume":"19","author":"Schulze","year":"2024","journal-title":"ChemMedChem"},{"key":"2026101315064990700_cit44","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1002\/mds.70168","article-title":"The Race to Salvage Glucocerebrosidase: Understanding\nSmall-Molecule Therapies for GBA1-Associated Parkinsonism","volume":"41","author":"Henderson","year":"2026","journal-title":"Mov. Disord."},{"key":"2026101315064990700_cit45","doi-asserted-by":"publisher","first-page":"5705","DOI":"10.1039\/C9CC02427A","article-title":"Direct biocatalysed synthesis of first sulfur-, selenium-\nand tellurium- containing l-ascorbyl hybrid derivatives with\nradical trapping and GPx-like properties","volume":"55","author":"Tanini","year":"2019","journal-title":"Chem.\nCommun."},{"key":"2026101315064990700_cit46","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3390\/ijms18020441","article-title":"A Review of Gaucher Disease Pathophysiology,\nClinical Presentation and Treatments","volume":"18","author":"Stirnemann","year":"2017","journal-title":"Int. J.\nMol. Sci."},{"key":"2026101315064990700_cit47","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s42004-024-01164-9","article-title":"A Practical Synthesis\nof Nitrone-Derived C5a-Functionalized\nIsofagomines as Protein Stabilizers to Treat Gaucher Disease","volume":"7","author":"Li","year":"2024","journal-title":"Commun. Chem."},{"key":"2026101315064990700_cit48","doi-asserted-by":"publisher","first-page":"15428","DOI":"10.1073\/pnas.192582899","article-title":"Chemical Chaperones\nIncrease the Cellular Activity\nof N370S \u03b2-Glucosidase: A Therapeutic Strategy for Gaucher Disease","volume":"99","author":"Sawkar","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026101315064990700_cit49","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.braindev.2012.05.008","article-title":"The Chaperone\nActivity and Toxicity of Ambroxol on Gaucher Cells and Normal Mice","volume":"35","author":"Zhang","year":"2013","journal-title":"Brain Dev."},{"key":"2026101315064990700_cit50","doi-asserted-by":"publisher","first-page":"103740","DOI":"10.1016\/j.bioorg.2020.103740","article-title":"Glucocerebrosidase\n(GCase) Activity Modulation by 2-Alkyl Trihydroxypiperidines: Inhibition\nand Pharmacological Chaperoning","volume":"98","author":"Clemente","year":"2020","journal-title":"Bioorg. Chem."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c08401","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/40\/62107\/68729601\/acsomega.6c08401.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/40\/62107\/68729601\/acsomega.6c08401.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:04:58Z","timestamp":1791921898000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/40\/62107\/5443539\/A-pH-Dependent-Curcumin-Iminosugar-Hybrid-Promotes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":50,"journal-issue":{"issue":"40","published-online":{"date-parts":[[2026,10,1]]},"published-print":{"date-parts":[[2026,10,13]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c08401","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}