{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:15:42Z","timestamp":1788329742985,"version":"build-2803163510"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T00:00:00Z","timestamp":1503360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/na","name":"Council of Scientific and Industrial research (CSIR), Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BSC0123"],"award-info":[{"award-number":["BSC0123"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The classic G-quadruplex motif consists of a continuous array of 3\u20134 guanine residues with an intermittent loop size of 1\u20137 nucleotides (G3\u20134N1\u20137G3\u20134N1\u20137G3\u20134N1\u20137G3\u20134). An RNA G-quadruplex is able to attain only one parallel G-quadruplex topology owing to steric constraints. Investigating the possibilities of the formation of RNA G-quadruplexes with a stretch of sequences deviating from this classic motif will add to the overall conformations of RNA G-quadruplexes, bestowing diversity to this structure. Here, we report unusual combinations of guanine residues involved in RNA G-quadruplex formation in the 5\u2032 untranslated region (UTR) of the von Willebrand factor (VWF) mRNA using the mutagenesis approach. Different permutations and combinations of guanine residues form G-quadruplexes. Upon investigation, G-quadruplexes in 5\u2032 UTR of VWF mRNA are shown to exhibit an inhibitory function.<\/jats:p>","DOI":"10.1021\/acsomega.7b00377","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T11:45:45Z","timestamp":1503402345000},"page":"4790-4799","source":"Crossref","is-referenced-by-count":2,"title":["Mutagenesis Reveals an Unusual Combination of Guanines\nin RNA G-Quadruplex Formation"],"prefix":"10.1021","volume":"2","author":[{"given":"Prachi","family":"Agarwala","sequence":"first","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology , , Mall Road , ,","place":["Delhi, India, 110007"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan, 2 Rafi Marg , ,","place":["New Delhi, India, 110001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gargi","family":"Pal","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan, 2 Rafi Marg , ,","place":["New Delhi, India, 110001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyaprakash","family":"Pandey","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology , , Mall Road , ,","place":["Delhi, India, 110007"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan, 2 Rafi Marg , ,","place":["New Delhi, India, 110001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9897-1419","authenticated-orcid":true,"given":"Souvik","family":"Maiti","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology , , Mall Road , ,","place":["Delhi, India, 110007"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan, 2 Rafi Marg , ,","place":["New Delhi, India, 110001"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,8,22]]},"reference":[{"key":"2026090201493103300_cit1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/356164a0","article-title":"Quadruplex structure of Oxytricha telomeric DNA oligonucleotides","volume":"356","author":"Smith","year":"1992","journal-title":"Nature"},{"key":"2026090201493103300_cit2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nchembio723","article-title":"Small-molecule interaction\nwith a five-guanine-tract G-quadruplex structure from the human MYC\npromoter","volume":"1","author":"Phan","year":"2005","journal-title":"Nat. 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Chem. Biol."},{"key":"2026090201493103300_cit30","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/nsmb.2865","article-title":"Structural\nbasis for activity of highly efficient RNA mimics of green fluorescent\nprotein","volume":"21","author":"Warner","year":"2014","journal-title":"Nat. Struct. Mol. 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