{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:42:36Z","timestamp":1790044956010,"version":"4.0.1"},"reference-count":13,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurotransmitters are the key factors in ameliorating the symptoms of nervous system diseases. Stroke\/cerebral ischemia has been proven to be caused by the excess release of excitatory amino acid glutamate in the brain, and the inhibitory neurotransmitter \u03b3-aminobutyric acid (GABA) is considered to be the best choice to counteract the action of glutamate. Here, we show that GABA conjugated to a cytoplasmic transduction peptide (YGRRARRRRRR) by means of custom chemical synthesis could penetrate through the blood\u2013brain barrier, increasing the GABA level in the plasma of rats and mice, which, as a result, display a state of calmness and somnolence.<\/jats:p>","DOI":"10.1021\/acsomega.7b00425","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T13:46:46Z","timestamp":1501595206000},"page":"4108-4111","source":"Crossref","is-referenced-by-count":12,"title":["BBB: Permeable Conjugate of Exogenic GABA"],"prefix":"10.1021","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3039-1896","authenticated-orcid":true,"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"Academy of Military Medical Sciences , , ,","place":["Beijing, China, 100850"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences , , ,","place":["Beijing, China, 100850"]},{"name":"Beijing Gleckes Wine Co. Ltd , ,","place":["Beijing, China, 101500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences , , ,","place":["Beijing, China, 100850"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqian","family":"Huang","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences , , ,","place":["Beijing, China, 100850"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences , , ,","place":["Beijing, China, 100850"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manji","family":"Sun","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences , , ,","place":["Beijing, China, 100850"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,8,1]]},"reference":[{"key":"2026090203593254200_cit1","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.neuropharm.2008.05.031","article-title":"The cost of cerebral ischaemia","volume":"55","author":"Flynn","year":"2008","journal-title":"Neuropharmacology"},{"key":"2026090203593254200_cit2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1046\/j.1471-4159.2001.00274.x","article-title":"gamma-aminobutyric\nacid(A) neurotransmission and cerebral ischemia","volume":"77","author":"Schwartz-Bloom","year":"2001","journal-title":"J. Neurochem."},{"key":"2026090203593254200_cit3","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.addr.2004.10.007","article-title":"Intracellular delivery of large molecules\nand small particles by cell-penetrating proteins and peptides","volume":"57","author":"Gupta","year":"2005","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026090203593254200_cit4","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.neulet.2004.05.116","article-title":"Alternative\ntherapy of Alzheimer\u2019s Disease via supplementation with choline\nacetyltransferase","volume":"368","author":"Fu","year":"2004","journal-title":"Neurosci. Lett."},{"key":"2026090203593254200_cit5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2006.03.247","article-title":"A novel therapeutic approach to 6-OHDA-induced\nParkinson\u2019s disease in rats via supplementation of PTD-conjugated\ntyrosine hydroxylase","volume":"346","author":"Wu","year":"2006","journal-title":"Biochem. Biophys. Res.\nCommun."},{"key":"2026090203593254200_cit6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.brainres.2007.10.097","article-title":"Transduced\nPTD-BDNF fusion protein\nprotects against beta amyloid peptide-induced learning and memory","volume":"1191","author":"Zhou","year":"2008","journal-title":"Brain Res."},{"key":"2026090203593254200_cit7","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ejphar.2008.06.109","article-title":"Transducible\nP11-CNTF rescues the learning and memory\nimpairments induced by amyloid-beta peptide in mice","volume":"594","author":"Qu","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"2026090203593254200_cit8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpharm.2010.11.018","article-title":"Amelioration of\ndementia induced by A\u03b2 22\u201335 through rectal delivery\nof undecapeptide-hEGF to mouse brain","volume":"405","author":"Zhao","year":"2011","journal-title":"Int. J.\nPharm."},{"key":"2026090203593254200_cit9","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.yexcr.2005.12.029","article-title":"Cytoplasmic transduction\npeptide (CTP): new approach for the delivery of biomolecules into\ncytoplasm in vitro and in vivo","volume":"312","author":"Kim","year":"2006","journal-title":"Exp. Cell Res."},{"key":"2026090203593254200_cit10","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.16161","article-title":"The fusion\nprotein of CTP-HBcAg18\u201327-Tapasin\nmediates the apoptosis of CD8+T cells and CD8+ T cell response in\nHLA-A2 transgenic mice","volume":"14","author":"Tang","year":"2014","journal-title":"Hepat. Mon."},{"key":"2026090203593254200_cit11","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1038\/bjc.2015.430","article-title":"A phase I\/IIa study of adjuvant immunotherapy with\ntumour antigen-pulsed dendritic cells in patients with hepatocellular\ncarcinoma","volume":"113","author":"Lee","year":"2015","journal-title":"Br. J. Cancer"},{"key":"2026090203593254200_cit12","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/mt.2011.284","article-title":"Cell-penetrating peptides as versatile\nvehicles for oligonucleotide delivery","volume":"20","author":"Margus","year":"2012","journal-title":"Mol.\nTher."},{"key":"2026090203593254200_cit13","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1110\/ps.051393805","article-title":"Polyarginine as a multifunctional\nfusion tag","volume":"14","author":"Fuchs","year":"2005","journal-title":"Protein Sci."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.7b00425","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/2\/8\/4108\/67654797\/acsomega.7b00425.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/2\/8\/4108\/67654797\/acsomega.7b00425.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:59:38Z","timestamp":1788335978000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/2\/8\/4108\/749327\/BBB-Permeable-Conjugate-of-Exogenic-GABA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,1]]},"references-count":13,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,1]]},"published-print":{"date-parts":[[2017,8,31]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.7b00425","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,1]]}}}