{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:11:47Z","timestamp":1788513107778,"version":"build-2803163510"},"reference-count":83,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T00:00:00Z","timestamp":1503878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2014\/001220"],"award-info":[{"award-number":["EMR\/2014\/001220"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A simple, catalyst-free, straightforward, and highly efficient one-pot synthesis of pharmaceutically interesting diverse kind of a new series of functionalized 5-aryl-2-oxo-\/thioxo-2,3-dihydro-1H-benzo[6,7]chromeno[2,3-d]pyrimidine-4,6,11(5H)-triones 4 (4-1\u20134-37) and substituted 5,5\u2032-(1,4-phenylene)bis(2-oxo-\/thioxo-2,3-dihydro-1H-benzo[6,7]chromeno[2,3-d]pyrimidine-4,6,11(5H)-trione) derivatives 4\u2032 (4\u2032-1\u20134\u2032-3) has been developed based on a three-component reaction between barbituric acid\/N,N-dimethylbarbituric acid\/2-thiobarbituric acid (1), aromatic aldehydes (2), and 2-hydroxy-1,4-naphthoquinone (3) in aqueous ethanol at room temperature (25\u201330 \u00b0C). The salient features of this protocol are mild reaction conditions, use of no catalyst, no need of column chromatographic purification, excellent yields, high atom economy, eco-friendliness, easy isolation of products, and reusability of reaction media.<\/jats:p>","DOI":"10.1021\/acsomega.7b00791","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T09:12:13Z","timestamp":1503911533000},"page":"5025-5035","source":"Crossref","is-referenced-by-count":49,"title":["Catalyst-Free One-Pot Three-Component Synthesis of\nDiversely Substituted 5-Aryl-2-oxo-\/thioxo-2,3-dihydro-1\n                    <i>H<\/i>\n                    -benzo[6,7]chromeno[2,3-\n                    <i>d<\/i>\n                    ]pyrimidine-4,6,11(5\n                    <i>H<\/i>\n                    )-triones Under Ambient\nConditions"],"prefix":"10.1021","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-6281","authenticated-orcid":true,"given":"Goutam","family":"Brahmachari","sequence":"first","affiliation":[{"name":"Visva-Bharati (A Central University) , , , ,","place":["Santiniketan, West Bengal, India, 731 235"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayana","family":"Nayek","sequence":"additional","affiliation":[{"name":"Visva-Bharati (A Central University) , , , ,","place":["Santiniketan, West Bengal, India, 731 235"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,8,28]]},"reference":[{"key":"2026090319093130400_cit1","doi-asserted-by":"publisher","first-page":"16852","DOI":"10.3390\/molecules200916852","article-title":"Heterocyclic anticancer compounds:\nRecent advances and the paradigm shift towards the use of nanomedicine\u2019s\ntool box","volume":"20","author":"Martins","year":"2015","journal-title":"Molecules"},{"key":"2026090319093130400_cit2","doi-asserted-by":"publisher","first-page":"10257","DOI":"10.1021\/jm501100b","article-title":"Analysis\nof the structural diversity,\nsubstitution patterns, and frequency of nitrogen heterocycles among\nU.S. FDA approved pharmaceuticals","volume":"57","author":"Vitaku","year":"2014","journal-title":"J. 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