{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:12:00Z","timestamp":1788513120952,"version":"build-2803163510"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cesium\u2013gold (Cs\u2013Au) nanoparticles are shown to be analytically advantageous for the electroanalytical sensing of dapoxetine (DPX), a serotonin reuptake inhibitor used for the treatment of premature ejaculation. The Cs\u2013Au nanoparticles are electrically wired and supported upon mass producible, economical screen-printed electrochemical sensing platforms and are characterized electrochemically (cyclic voltammetry and electrochemical impedance spectroscopy) and physiochemically (field emission scanning electron microscopy and energy dispersive X-ray analysis). The face-centered design was applied to optimize the significant experimental factors by using square wave voltammetry. The Cs\u2013Au-based sensor is found to exhibit a large linear range (10\u20137 to 10\u20134 M) with a good analytical linearity with the limits of detection and quantification corresponding to 2.50 \u00d7 10\u201310 and 8.33 \u00d7 10\u20138 M, respectively. The developed sensor was successfully applied in the quantification of DPX in the presence of sildenafil, both of which are commonly found within combined dose tablet pharmaceutical formulations. The proposed DPX electrochemical Cs\u2013Au-based sensor has the advantages of being single-shot and disposable and is shown to be successful in determining DPX in pharmaceutical formulations, human urine, and serum samples with acceptable recoveries.<\/jats:p>","DOI":"10.1021\/acsomega.7b01193","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T13:59:14Z","timestamp":1507730354000},"page":"6628-6635","source":"Crossref","is-referenced-by-count":29,"title":["Electrochemical Determination of the Serotonin Reuptake\nInhibitor, Dapoxetine, Using Cesium\u2013Gold Nanoparticles"],"prefix":"10.1021","volume":"2","author":[{"given":"Mona A.","family":"Mohamed","sequence":"first","affiliation":[{"name":"National Organization for Drug Control and Research [NODCAR] , , Pyramids Ave, P.O. Box 29, ,","place":["Giza, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimaa A.","family":"Atty","sequence":"additional","affiliation":[{"name":"National Organization for Drug Control and Research [NODCAR] , , Pyramids Ave, P.O. Box 29, ,","place":["Giza, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali M.","family":"Yehia","sequence":"additional","affiliation":[{"name":"Cairo University , , ,","place":["Cairo, Egypt, 11562"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5487-2803","authenticated-orcid":true,"given":"Christopher W.","family":"Foster","sequence":"additional","affiliation":[{"name":"Manchester Metropolitan University , , Chester Street , ,","place":["Manchester, U.K., M1 5GD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-9764","authenticated-orcid":true,"given":"Craig E.","family":"Banks","sequence":"additional","affiliation":[{"name":"Manchester Metropolitan University , , Chester Street , ,","place":["Manchester, U.K., M1 5GD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9458-3507","authenticated-orcid":true,"given":"Nageh K.","family":"Allam","sequence":"additional","affiliation":[{"name":"The American University in Cairo , , ,","place":["New Cairo, Egypt, 11835"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"2026090320120123800_cit1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.4103\/2229-4708.90364","article-title":"Development and Validation of UV Spectrophotometric\nmethod for estimation of Dapoxetine HCL in bulk and dosage Form","volume":"5","author":"Vineeta","year":"2013","journal-title":"Int. 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