{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:55:35Z","timestamp":1793714135800,"version":"4.6.1"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/PR6804\/GBD\/27\/486\/2012"],"award-info":[{"award-number":["BT\/PR6804\/GBD\/27\/486\/2012"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SR\/FT\/LS-57\/2012"],"award-info":[{"award-number":["SR\/FT\/LS-57\/2012"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Human Resource Development","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Early detection is the critical phase in the prognostic strategy of various life-threatening maladies like infectious diseases and cancer. The mortality rate caused by these diseases could be considerably reduced if they were diagnosed in the early stages of disease development. Carbon dots (C-dots), a relatively new and promising candidate in the fluorescent nanomaterial category, possess a perceptible impact on various bioapplications. Herein, we report a one-step facile hydrothermal synthesis that yields a novel surface-passivated carbon dot (CDP) from curcumin (as a green substrate) displaying high aqueous solubility. The physico-chemical characterization of thus synthesized C-dots was accomplished by an UV\u2013visible spectrophotometer, fluorescence spectrophotometer, zetasizer, TEM, and FE-SEM to understand the formation of carbon dots with a 4\u20135 nm size near spherical nanoparticle with high colloidal stability. E. coli DH5\u03b1 was engaged as the Gram-negative test organism and S. aureus as the Gram-positive in the biolabeling of bacteria. Cancer cell lines including colon cancer (HCT-15), lung cancer (A549), and mouse fibroblast (NIH 3T3) were evaluated and resulted in good biolabeling potential and less cytotoxicity. Zebrafish (ASWT) embryos as an animal model system were bioimaged, and in vivo toxicity was inferred. Moreover, the synthesized C-dots were shown to have free radical scavenging activity in a dose-dependent manner. The unpassivated C-dots (CD) were found to sense ferric ions at the micromolar concentration level. The findings of our study suggest that the multifunctional potentiality of CDPs serves as high-performance optical nanoprobes and can be a suitable alternative for various biolabeling and contrasting agents.<\/jats:p>","DOI":"10.1021\/acsomega.7b01323","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T09:16:54Z","timestamp":1516699014000},"page":"831-843","source":"Crossref","is-referenced-by-count":260,"title":["Facile and Green Synthesis of Multicolor Fluorescence\nCarbon Dots from Curcumin:\n                    <i>In Vitro<\/i>\n                    and\n                    <i>in Vivo<\/i>\n                    Bioimaging and Other Applications"],"prefix":"10.1021","volume":"3","author":[{"given":"Tathagata","family":"Pal","sequence":"first","affiliation":[{"name":"Indian Institute of Technology Roorkee , , , ,","place":["Roorkee, Uttarakhand, India, 247667"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanid","family":"Mohiyuddin","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Roorkee , , , ,","place":["Roorkee, Uttarakhand, India, 247667"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1379-1203","authenticated-orcid":true,"given":"Gopinath","family":"Packirisamy","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Roorkee , , , ,","place":["Roorkee, Uttarakhand, India, 247667"]},{"name":"Indian Institute of Technology Roorkee , , , ,","place":["Roorkee, Uttarakhand, India, 247667"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"issue":"1","key":"2026090117092125900_cit1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1359-6454(99)00285-2","article-title":"Nanostructured\nMaterials: Basic Concepts and Microstructure","volume":"48","author":"Gleiter","year":"2000","journal-title":"Acta Mater."},{"issue":"28","key":"2026090117092125900_cit2","doi-asserted-by":"publisher","first-page":"4862","DOI":"10.1039\/C6TB01178K","article-title":"Multifunctional Carbon\nDots as Efficient\nFluorescent Nanotags for Tracking Cells through Successive Generations","volume":"4","author":"Bhushan","year":"2016","journal-title":"J. Mater. Chem. B"},{"issue":"38","key":"2026090117092125900_cit3","doi-asserted-by":"publisher","first-page":"16958","DOI":"10.1039\/c3ra42415d","article-title":"A Novel One-Step Synthesis\nof PEG Passivated Multicolour\nFluorescent Carbon Dots for Potential Biolabeling Application","volume":"3","author":"Sachdev","year":"2013","journal-title":"RSC Adv."},{"issue":"21","key":"2026090117092125900_cit4","doi-asserted-by":"publisher","first-page":"11423","DOI":"10.1021\/acsami.5b02095","article-title":"Self-Assembled\nHybrids of Fluorescent\nCarbon Dots and PAMAM Dendrimers for Epirubicin Delivery and Intracellular\nImaging","volume":"7","author":"Matai","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"3","key":"2026090117092125900_cit5","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.partic.2012.09.008","article-title":"Preparation of Photoluminescent\nCarbon Dots-Embedded Polyelectrolyte Microcapsules","volume":"11","author":"Yang","year":"2013","journal-title":"Particuology"},{"issue":"34","key":"2026090117092125900_cit6","doi-asserted-by":"publisher","first-page":"17470","DOI":"10.1039\/c2jm32827e","article-title":"Carbon Quantum\ndots\/Cu2O\nComposites with Protruding Nanostructures and Their Highly Efficient\n(near) Infrared Photocatalytic Behavior","volume":"22","author":"Li","year":"2012","journal-title":"J.\nMater. Chem."},{"key":"2026090117092125900_cit7","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1007\/s13391-017-6285-4","article-title":"Investigation of Structural, Spectral and Photometric Properties\nof CaTiO3:Dy3+ Nanophosphors for the Lighting Applications","volume":"13","author":"Singh","year":"2017","journal-title":"Electron. Mater. Lett."},{"issue":"41","key":"2026090117092125900_cit8","doi-asserted-by":"publisher","first-page":"10822","DOI":"10.1039\/c1dt11147g","article-title":"Fe2O3\/carbon\nQuantum Dots Complex Photocatalysts and Their Enhanced Photocatalytic\nActivity under Visible Light","volume":"40","author":"Zhang","year":"2011","journal-title":"Dalt. Trans."},{"issue":"2","key":"2026090117092125900_cit9","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.materresbull.2012.10.052","article-title":"Preparation and Characterization\nof Photocatalytic Carbon Dots-Sensitized Electrospun Titania Nanostructured\nFibers","volume":"48","author":"Li","year":"2013","journal-title":"Mater. Res. Bull."},{"issue":"17","key":"2026090117092125900_cit10","doi-asserted-by":"publisher","first-page":"8065","DOI":"10.1021\/ac401880h","article-title":"Carbon Quantum Dot-Functionalized\nAerogels for NO2 Gas Sensing","volume":"85","author":"Wang","year":"2013","journal-title":"Anal. Chem."},{"issue":"4","key":"2026090117092125900_cit11","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1039\/B812943F","article-title":"One-Step Synthesis\nof Fluorescent Carbon Nanoparticles by Laser Irradiation","volume":"19","author":"Hu","year":"2009","journal-title":"J. Mater. Chem."},{"issue":"15","key":"2026090117092125900_cit12","doi-asserted-by":"publisher","first-page":"7461","DOI":"10.1039\/c2jm16835a","article-title":"Facile Synthesis of\nWater-Soluble, Highly Fluorescent\nGraphene Quantum Dots as a Robust Biological Label for Stem Cells","volume":"22","author":"Zhang","year":"2012","journal-title":"J. Mater. Chem."},{"issue":"3","key":"2026090117092125900_cit13","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1039\/C1CC15678K","article-title":"One-Step Synthesis\nof Amino-Functionalized\nFluorescent Carbon Nanoparticles by Hydrothermal Carbonization of\nChitosan","volume":"48","author":"Yang","year":"2012","journal-title":"Chem. Commun."},{"issue":"75","key":"2026090117092125900_cit14","doi-asserted-by":"publisher","first-page":"9367","DOI":"10.1039\/c2cc33844k","article-title":"Bifunctional\nFluorescent Carbon Nanodots:\nGreen Synthesis via Soy Milk and Application as Metal-Free Electrocatalysts\nfor Oxygen Reduction","volume":"48","author":"Zhu","year":"2012","journal-title":"Chem. Commun."},{"issue":"22","key":"2026090117092125900_cit15","doi-asserted-by":"publisher","first-page":"4577","DOI":"10.1039\/C5TB00467E","article-title":"Ultrastable\nGreen Fluorescence Carbon Dots with a High Quantum Yield for Bioimaging\nand Use as Theranostic Carriers","volume":"3","author":"Yang","year":"2015","journal-title":"J. Mater. Chem.\nB"},{"issue":"17","key":"2026090117092125900_cit16","doi-asserted-by":"publisher","first-page":"3476","DOI":"10.1039\/C4TB02067G","article-title":"Self-Polymerization\nof Dopamine and Polyethyleneimine: Novel Fluorescent Organic Nanoprobes\nfor Biological Imaging Applications","volume":"3","author":"Liu","year":"2015","journal-title":"J. Mater.\nChem. B"},{"issue":"21","key":"2026090117092125900_cit17","doi-asserted-by":"publisher","first-page":"7747","DOI":"10.1039\/c3ra40549d","article-title":"Enhanced Fluorescence Quenching of Hemin Detected by\na Novel Polymer of Curcumin","volume":"3","author":"Gogoi","year":"2013","journal-title":"RSC Adv."},{"issue":"30","key":"2026090117092125900_cit18","doi-asserted-by":"publisher","first-page":"11582","DOI":"10.1039\/C6TA04813G","article-title":"Improving the Functionality\nof Carbon Nanodots: Doping and Surface Functionalization","volume":"4","author":"Park","year":"2016","journal-title":"J. Mater. Chem. 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Med.\nChem."},{"issue":"3","key":"2026090117092125900_cit21","first-page":"104","article-title":"WHO Guidelines for Drinking-Water\nQuality","volume":"38","author":"Gorchev","year":"2011","journal-title":"WHO Chron."},{"key":"2026090117092125900_cit22","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.aca.2014.12.045","article-title":"Facile\nSynthesis of Nitrogen-Doped\nCarbon Dots for Fe3+ Sensing and Cellular Imaging","volume":"861","author":"Gong","year":"2015","journal-title":"Anal. Chim. Acta"},{"issue":"29","key":"2026090117092125900_cit23","doi-asserted-by":"publisher","first-page":"4631","DOI":"10.1039\/c4tb00368c","article-title":"Green Synthesis\nof Nitrogen-Doped\nCarbon Dots from Konjac Flour With \u201coff-On\u201d fluorescence\nby Fe3+ and L-Lysine for Bioimaging","volume":"2","author":"Teng","year":"2014","journal-title":"J. Mater.\nChem. 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Rev."},{"issue":"2","key":"2026090117092125900_cit27","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nrc2981","article-title":"Regulation of Cancer Cell Metabolism","volume":"11","author":"Cairns","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"11","key":"2026090117092125900_cit28","doi-asserted-by":"publisher","first-page":"7002","DOI":"10.1021\/acs.est.5b01910","article-title":"Fish Embryo Toxicity Test: Identification\nof Compounds with Weak Toxicity and Analysis of Behavioral Effects\nTo Improve Prediction of Acute Toxicity for Neurotoxic Compounds","volume":"49","author":"Klu\u0308ver","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"7","key":"2026090117092125900_cit29","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1016\/j.theriogenology.2005.03.018","article-title":"The Effect\nof External Medium Composition\non Membrane Water Permeability of Zebrafish (Danio Rerio) Embryos","volume":"64","author":"Adams","year":"2005","journal-title":"Theriogenology"},{"key":"2026090117092125900_cit30","doi-asserted-by":"publisher","first-page":"11835","DOI":"10.1038\/srep11835","article-title":"Carbon Quantum Dots for Zebrafish\nFluorescence Imaging","volume":"5","author":"Kang","year":"2015","journal-title":"Sci. Rep."},{"issue":"12","key":"2026090117092125900_cit31","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1039\/C5AN00454C","article-title":"Green Synthesis of\nMultifunctional Carbon Dots from\nCoriander Leaves and Their Potential Application as Antioxidants,\nSensors and Bioimaging Agents","volume":"140","author":"Sachdev","year":"2015","journal-title":"Analyst"},{"issue":"1","key":"2026090117092125900_cit32","doi-asserted-by":"publisher","first-page":"e0147823","DOI":"10.1371\/journal.pone.0147823","article-title":"Chamber Specific\nGene Expression\nLandscape of the Zebrafish Heart","volume":"11","author":"Singh","year":"2016","journal-title":"PLoS One"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.7b01323","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/3\/1\/831\/67525685\/acsomega.7b01323.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/3\/1\/831\/67525685\/acsomega.7b01323.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:09:27Z","timestamp":1788296967000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/3\/1\/831\/751395\/Facile-and-Green-Synthesis-of-Multicolor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,23]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,23]]},"published-print":{"date-parts":[[2018,1,31]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.7b01323","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,23]]}}}