{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:22:38Z","timestamp":1790702558870,"version":"4.1.0"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100008050","name":"Fundaci\u00f3n Cellex","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100008050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["CTQ2012-39230"],"award-info":[{"award-number":["CTQ2012-39230"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["CTQ2015-71506-R"],"award-info":[{"award-number":["CTQ2015-71506-R"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["CTQ2012-39230"],"award-info":[{"award-number":["CTQ2012-39230"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["CTQ2015-71506-R"],"award-info":[{"award-number":["CTQ2015-71506-R"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The binding site of the macrolides laulimalide and peloruside A, which is different from that of the clinically useful drugs paclitaxel\/taxol and ixabepilone (tax site), is known to be between two adjacent \u03b2-tubulin units (ext site). Here, we report our study of the binding of these molecules to an \u03b11\u03b21\/\u03b12\u03b22-tubulin \u201ctetramer\u201d model. AutoDock 4.2.6\/\/AutoDock Vina dockings predicted that the affinities of laulimalide and peloruside A for the tax site are quite similar to those for the ext site. However, molecular dynamics (MD) simulations indicated that only when these two ligands are located at the ext site, there are contacts that help stabilize the system, favoring the \u03b21\/\u03b22 interactions. The binding affinity of laulimalide for this site is stronger than that of peloruside A, but this is compensated for by additional \u03b21\/\u03b22 contacts that are induced by peloruside A. MD studies also suggested that epothilones at the tax site and either laulimalide or peloruside A at the ext site cause similar stabilizing effects (mainly linking the M-loop of \u03b21 and loop H1\u2013B2 of \u03b22). In a \u201chexamer\u201d model (3 units of \u03b1\u03b2-tubulin), the effects are confirmed. Metadynamics simulations of laulimalide and peloruside A, which are reported for the first time, suggest that peloruside A produces a stronger change in the M-loop, which explains the stabilization of the \u03b21\/\u03b22 interaction.<\/jats:p>","DOI":"10.1021\/acsomega.7b01723","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T14:48:22Z","timestamp":1518187702000},"page":"1770-1782","source":"Crossref","is-referenced-by-count":12,"title":["Further Insight into the Interactions of the Cytotoxic\nMacrolides Laulimalide and Peloruside A with Their Common Binding\nSite"],"prefix":"10.1021","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8360-8027","authenticated-orcid":true,"given":"Alejandro","family":"Castro-Alvarez","sequence":"first","affiliation":[{"name":"Universitat de Barcelona , , Diagonal 645 , , ,","place":["Barcelona, Catalonia, Spain, 08028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Pineda","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona , , Diagonal 645 , , ,","place":["Barcelona, Catalonia, Spain, 08028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-8218","authenticated-orcid":true,"given":"Jaume","family":"Vilarrasa","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona , , Diagonal 645 , , ,","place":["Barcelona, Catalonia, Spain, 08028"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"2026090207573467100_cit1","first-page":"653","article-title":"Laulimalide and isolaulimalide, new paclitaxel-like\nmicrotubule-stabilizing agents","volume":"59","author":"Mooberry","year":"1999","journal-title":"Cancer Res."},{"key":"2026090207573467100_cit2","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1021\/jo991296y","article-title":"Peloruside A: a potent cytotoxic\nmacrolide isolated from the New Zealand marine sponge Mycale sp.","volume":"65","author":"West","year":"2000","journal-title":"J. Org. Chem."},{"key":"2026090207573467100_cit3","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1007\/s10637-017-0493-5","article-title":"Induction of accelerated senescence by the microtubule-stabilizing\nagent peloruside A","volume":"35","author":"Chan","year":"2017","journal-title":"Invest. New Drugs"},{"key":"2026090207573467100_cit4","doi-asserted-by":"publisher","first-page":"15917","DOI":"10.1039\/c7ra00370f","article-title":"Novel anti-tubulin\nagents from plant\nand marine origins: insight from a molecular modeling and dynamics\nstudy","volume":"7","author":"Yadava","year":"2017","journal-title":"RSC Adv."},{"key":"2026090207573467100_cit5","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s10822-017-0029-2","article-title":"Structural\ninsight into the role of Gln293Met mutation on the peloruside A\/laulimalide\nassociation with \u03b1\u03b2-tubulin from molecular dynamics simulations,\nbinding free energy calculations and weak interactions analysis","volume":"31","author":"Zu\u0301n\u0303iga","year":"2017","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"2026090207573467100_cit6","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3390\/molecules22071037","article-title":"An updated review on marine anticancer compounds: the use of virtual\nscreening for the discovery of small-molecule cancer drugs","volume":"22","author":"Ruiz-Torres","year":"2017","journal-title":"Molecules"},{"key":"2026090207573467100_cit7","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.jmb.2017.01.001","article-title":"Insights into\nthe distinct mechanisms of action of taxane and non-taxane microtubule\nstabilizers from cryo-em structures","volume":"429","author":"Kellogg","year":"2017","journal-title":"J. Mol.\nBiol."},{"key":"2026090207573467100_cit8","doi-asserted-by":"publisher","first-page":"357","DOI":"10.2174\/1568009616666160928110818","article-title":"Mechanisms of tubulin\nbinding ligands to target cancer cells: updates on their therapeutic\npotential and clinical trials","volume":"17","author":"Kumar","year":"2017","journal-title":"Curr. Cancer\nDrug Targets"},{"key":"2026090207573467100_cit9","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.pharmthera.2015.12.006","article-title":"Microtubule-stabilizing\nagents: new drug discovery\nand cancer therapy","volume":"162","author":"Zhao","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"2026090207573467100_cit10","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1039\/c5np00146c","article-title":"Peloruside A: a lead non-taxoid-site\nmicrotubule-stabilizing agent with potential activity against cancer,\nneurodegeneration, and autoimmune disease","volume":"33","author":"Kanakkanthara","year":"2016","journal-title":"Nat.\nProd. Rep."},{"key":"2026090207573467100_cit11","doi-asserted-by":"publisher","first-page":"5040","DOI":"10.1016\/j.bmc.2013.12.046","article-title":"Microtubule-stabilizing\nagents as potential therapeutics for neurodegenerative disease","volume":"22","author":"Brunden","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"2026090207573467100_cit12","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1039\/c3np70092e","article-title":"Recent progress with microtubule stabilizers: new compounds,\nbinding modes and cellular activities","volume":"31","author":"Rohena","year":"2014","journal-title":"Nat.\nProd. Rep."},{"key":"2026090207573467100_cit13","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.chembiol.2013.01.014","article-title":"The binding sites of microtubule-stabilizing\nagents","volume":"20","author":"Field","year":"2013","journal-title":"Chem. Biol."},{"key":"2026090207573467100_cit14","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.1007\/s11095-012-0809-2","article-title":"Peloruside, laulimalide, and noscapine\ninteractions with \u03b2-tubulin","volume":"29","author":"Gajewski","year":"2012","journal-title":"Pharm. Res."},{"key":"2026090207573467100_cit15","doi-asserted-by":"publisher","first-page":"5063","DOI":"10.1158\/0008-5472.can-04-0771","article-title":"Peloruside\nA does\nnot bind to the taxoid site on \u03b2-tubulin and retains its activity\nin multidrug-resistant cell lines","volume":"64","author":"Gaitanos","year":"2004","journal-title":"Cancer Res."},{"key":"2026090207573467100_cit16","doi-asserted-by":"publisher","first-page":"9109","DOI":"10.1021\/bi020211b","article-title":"The microtubule stabilizing\nagent laulimalide does not bind in the taxoid site, kills cells resistant\nto paclitaxel and epothilones, and may not require its epoxide moiety\nfor activity","volume":"41","author":"Pryor","year":"2002","journal-title":"Biochemistry"},{"key":"2026090207573467100_cit17","doi-asserted-by":"publisher","first-page":"4825","DOI":"10.1016\/j.bmcl.2004.07.053","article-title":"Computational comparison of microtubule-stabilising\nagents laulimalide and peloruside with taxol and colchicine","volume":"14","author":"Pineda","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"2026090207573467100_cit18","doi-asserted-by":"publisher","first-page":"8757","DOI":"10.1021\/ja0580237","article-title":"NMR determination\nof the bioactive conformation of\npeloruside A bound to microtubules","volume":"128","author":"Jime\u0301nez-Barbero","year":"2006","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026090207573467100_cit19","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.jmb.2008.03.026","article-title":"A unique\nmode of microtubule stabilization induced by peloruside A","volume":"378","author":"Huzil","year":"2008","journal-title":"J. Mol. Biol."},{"key":"2026090207573467100_cit20","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.chembiol.2010.05.019","article-title":"Discovery and characterization of the laulimalide-microtubule\nbinding mode by mass shift perturbation mapping","volume":"17","author":"Bennett","year":"2010","journal-title":"Chem. Biol."},{"key":"2026090207573467100_cit21","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1002\/anie.201307749","article-title":"Structural\nbasis of microtubule stabilization by laulimalide and peloruside A","volume":"53","author":"Prota","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026090207573467100_cit22","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1021\/ci1002894","article-title":"The assembly-inducing\nlaulimalide\/peloruside a binding site on tubulin: molecular modeling\nand biochemical studies with [3H]peloruside A","volume":"50","author":"Nguyen","year":"2010","journal-title":"J. Chem. Inf. Model."},{"key":"2026090207573467100_cit23","doi-asserted-by":"publisher","first-page":"11765","DOI":"10.1074\/jbc.m110.162214","article-title":"Hallmarks of molecular action of microtubule stabilizing agents:\neffects of epothilone B, ixabepilone, peloruside A, and laulimalide\non microtubule conformation","volume":"286","author":"Khrapunovich-Baine","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2026090207573467100_cit24","doi-asserted-by":"publisher","first-page":"702","DOI":"10.3109\/14756366.2013.845816","article-title":"Docking\nand molecular\ndynamics studies of the binding between peloruside A and tubulin","volume":"29","author":"Liao","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"2026090207573467100_cit25","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/cbdd.12475","article-title":"The unique\nbinding mode of laulimalide\nto two tubulin protofilaments","volume":"86","author":"Churchill","year":"2015","journal-title":"Chem. Biol. Drug\nDes."},{"key":"2026090207573467100_cit26","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1080\/07391102.2015.1078115","article-title":"Analysis of the binding mode of laulimalide\nto microtubules: establishing a laulimalide\u2013tubulin pharmacophore","volume":"34","author":"Churchill","year":"2016","journal-title":"J. Biomol. Struct. Dyn."},{"key":"2026090207573467100_cit27","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3390\/molecules22010136","article-title":"The performance of several docking\nprograms at reproducing protein\u2013macrolide-like crystal structures","volume":"22","author":"Castro-Alvarez","year":"2017","journal-title":"Molecules"},{"key":"2026090207573467100_cit28","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4\nand AutoDockTools4: automated\ndocking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"2026090207573467100_cit29","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving\nthe speed and accuracy of\ndocking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"2026090207573467100_cit30","doi-asserted-by":"publisher","first-page":"1541007","DOI":"10.1142\/s0219720015410073","article-title":"PSOVina:\nThe hybrid particle swarm\noptimization algorithm for protein\u2013ligand docking","volume":"13","author":"Ng","year":"2015","journal-title":"J. Bioinf. Comput. Biol."},{"key":"2026090207573467100_cit31","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","article-title":"The MM\/PBSA and MM\/GBSA\nmethods to estimate ligand-binding affinities","volume":"10","author":"Genheden","year":"2015","journal-title":"Expert Opin. Drug Discovery"},{"key":"2026090207573467100_cit32a","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1021\/ct900587b","article-title":"Prediction of absolute\nsolvation free energies using Molecular Dynamics free energy perturbation\nand the OPLS force field","volume":"6","author":"Shivakumar","year":"2010","journal-title":"J. Chem. Theory Comput."},{"key":"2026090207573467100_cit32","unstructured":"Desmond MD System, DE Shaw Research.\n          .  Maestro-Desmond Interoperability\nTools; Schro\u0308dinger: New York, 2017."},{"key":"2026090207573467100_cit33","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1083\/jcb.201007081","article-title":"Template-free\n13-protofilament microtubule\u2013MAP assembly visualized at 8 \u00c5\nresolution","volume":"191","author":"Fourniol","year":"2010","journal-title":"J. Cell Biol."},{"key":"2026090207573467100_cit34","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.bpj.2014.05.047","article-title":"Analysis of\nthe strength of interfacial hydrogen bonds between tubulin dimers\nusing quantum theory of atoms in molecules","volume":"107","author":"Ayoub","year":"2014","journal-title":"Biophys. J."},{"key":"2026090207573467100_cit35","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.bpj.2010.04.038","article-title":"Mechanical\nproperties of a complete microtubule revealed\nthrough molecular dynamics simulation","volume":"99","author":"Wells","year":"2010","journal-title":"Biophys.\nJ."},{"key":"2026090207573467100_cit36","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1124\/mol.66.1.113","article-title":"Laulimalide and paclitaxel: a comparison\nof their effects on tubulin assembly and their synergistic action\nwhen present simultaneously","volume":"66","author":"Gapud","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"2026090207573467100_cit37","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1124\/mol.106.027847","article-title":"Synergistic effects\nof peloruside\nA and laulimalide with taxoid site drugs, but not with each other,\non tubulin assembly","volume":"70","author":"Hamel","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"2026090207573467100_cit38","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1021\/mp060016h","article-title":"Laulimalide\nand synthetic laulimalide analogues are synergistic with paclitaxel\nand 2-methoxyestradiol","volume":"3","author":"Clark","year":"2006","journal-title":"Mol. Pharm."},{"key":"2026090207573467100_cit39","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s00280-010-1461-3","article-title":"Synergistic interactions between peloruside A and other\nmicrotubule-stabilizing and destabilizing agents in cultured human\novarian carcinoma cells and murine T cells","volume":"68","author":"Wilmes","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"key":"2026090207573467100_cit40","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/wcms.31","article-title":"Metadynamics","volume":"1","author":"Barducci","year":"2011","journal-title":"WIREs Comput. Mol. Sci."},{"key":"2026090207573467100_cit41","doi-asserted-by":"publisher","first-page":"5191","DOI":"10.1021\/ol8021676","article-title":"Stereocontrolled total synthesis\nof amphidinolide X via a silicon-tethered metathesis reaction","volume":"10","author":"Rodri\u0301guez-Escrich","year":"2008","journal-title":"Org. Lett."},{"key":"2026090207573467100_cit42","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1002\/cbic.201100042","article-title":"Mechanism\nof action of the cytotoxic macrolides amphidinolide X and J","volume":"12","author":"Trigili","year":"2011","journal-title":"ChemBioChem"},{"key":"2026090207573467100_cit43","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.tetlet.2013.12.047","article-title":"Synthesis\nof amphidinolide Y precursors","volume":"55","author":"Mola","year":"2014","journal-title":"Tetrahedron Lett."},{"key":"2026090207573467100_cit44","doi-asserted-by":"publisher","first-page":"8511","DOI":"10.1021\/acs.joc.5b00966","article-title":"Total synthesis\nof amphidinolide K, a macrolide that\nstabilizes F-actin","volume":"80","author":"Sa\u0301nchez","year":"2015","journal-title":"J. Org. Chem."},{"key":"2026090207573467100_cit45","doi-asserted-by":"publisher","first-page":"11021","DOI":"10.1021\/acs.joc.7b01973","article-title":"Formal total\nsynthesis of amphidinolide E","volume":"82","author":"Bosch","year":"2017","journal-title":"J. Org. Chem."},{"key":"2026090207573467100_cit46","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.chempr.2016.12.005","article-title":"Structural\nbasis of cis- and trans-combretastatin binding to tubulin","volume":"2","author":"Gaspari","year":"2017","journal-title":"Chem"},{"key":"2026090207573467100_cit47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003464","article-title":"The free\nenergy profile of tubulin straight-bent conformational changes, with\nimplications for microtubule assembly and drug discovery","volume":"10","author":"Peng","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"2026090207573467100_cit48","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1021\/ct3006612","article-title":"Free energy profile and kinetics\nstudies of paclitaxel internalization from the outer to the inner\nwall of microtubules","volume":"9","author":"Maccari","year":"2013","journal-title":"J. Chem. Theory Comput."},{"key":"2026090207573467100_cit49","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1006\/jmbi.2001.5077","article-title":"Refined structure of \u03b1\u03b2-tubulin\nat 3.5 \u00c5 resolution","volume":"313","author":"Lo\u0308we","year":"2001","journal-title":"J. Mol. Biol."},{"key":"2026090207573467100_cit50","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/34465","article-title":"Structure of the\n\u03b1\u03b2-tubulin\ndimer by electron crystallography","volume":"391","author":"Nogales","year":"1998","journal-title":"Nature"},{"key":"2026090207573467100_cit51","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.cell.2015.07.012","article-title":"Mechanistic origin\nof microtubule dynamic instability and its modulation by EB proteins","volume":"162","author":"Zhang","year":"2015","journal-title":"Cell"},{"key":"2026090207573467100_cit52","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1186\/1471-2105-15-s5-s1","article-title":"MDcons: Intermolecular\ncontact maps as a tool to analyze the interface of protein complexes\nfrom molecular dynamics trajectories","volume":"15","author":"Abdel-Azeim","year":"2014","journal-title":"BMC Bioinf."},{"key":"2026090207573467100_cit53","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"Gromacs: high performance\nmolecular simulations through multi-level parallelism from laptops\nto supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"2026090207573467100_cit54","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1021\/ci500020m","article-title":"g_mmpbsa\u2500A\nGROMACS tool for high-throughput MM-PBSA calculations","volume":"54","author":"Kumari","year":"2014","journal-title":"J. Chem. Inf. Model."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.7b01723","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/3\/2\/1770\/67729016\/acsomega.7b01723.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/3\/2\/1770\/67729016\/acsomega.7b01723.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:57:46Z","timestamp":1788350266000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/3\/2\/1770\/744381\/Further-Insight-into-the-Interactions-of-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":55,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,9]]},"published-print":{"date-parts":[[2018,2,28]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.7b01723","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,9]]}}}