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The introduction of a triazole ring among the synthesized conjugates improved the activity profiles with most of the compounds in the library, exhibiting 100% growth inhibition in a preliminary susceptibility screen at 100 \u03bcM. IC50 determination of the most potent compounds in the set revealed an inhibitory range between 2 and 13 \u03bcM. Normal flora microbiome are unaffected by these compounds, suggesting that these may be new chemical scaffolds for the discovery of new drugs against trichomonad infections.<\/jats:p>","DOI":"10.1021\/acsomega.8b00553","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T07:39:17Z","timestamp":1527665957000},"page":"5808-5813","source":"Crossref","is-referenced-by-count":35,"title":["Synthesis and Preliminary Antimicrobial Analysis of\nIsatin\u2013Ferrocene and Isatin\u2013Ferrocenyl Chalcone Conjugates"],"prefix":"10.1021","volume":"3","author":[{"given":"Amandeep","family":"Singh","sequence":"first","affiliation":[{"name":"Guru Nanak Dev University , , , ,","place":["Amritsar, Punjab, India, 143005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Fong","sequence":"additional","affiliation":[{"name":"University of the Pacific , , , ,","place":["Stockton, California, United States, 95211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Liu","sequence":"additional","affiliation":[{"name":"University of the Pacific , , , ,","place":["Stockton, California, United States, 95211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Hsuan","family":"Wu","sequence":"additional","affiliation":[{"name":"University of the Pacific , , , ,","place":["Stockton, California, United States, 95211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Chang","sequence":"additional","affiliation":[{"name":"University of the Pacific , , , ,","place":["Stockton, California, United States, 95211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Park","sequence":"additional","affiliation":[{"name":"University of the Pacific , , , ,","place":["Stockton, California, United States, 95211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihwan","family":"Kim","sequence":"additional","affiliation":[{"name":"University of the Pacific , , , ,","place":["Stockton, California, United States, 95211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Tam","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture , , , ,","place":["Albany, California, United States, 94710"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa W.","family":"Cheng","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture , , , ,","place":["Albany, California, United States, 94710"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirkwood M.","family":"Land","sequence":"additional","affiliation":[{"name":"University of the Pacific , , , ,","place":["Stockton, California, United States, 95211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-7161","authenticated-orcid":true,"given":"Vipan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Guru Nanak Dev University , , , ,","place":["Amritsar, Punjab, India, 143005"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,5,30]]},"reference":[{"key":"2026090321092738100_cit1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/olq.0b013e318286bb53","article-title":"Sexually transmitted\ninfections among US women and men","volume":"40","author":"Satterwhite","year":"2013","journal-title":"Sex. 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