{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:13:10Z","timestamp":1788513190983,"version":"build-2803163510"},"reference-count":28,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["F32AI126628"],"award-info":[{"award-number":["F32AI126628"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["UH3DA041146"],"award-info":[{"award-number":["UH3DA041146"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fentanyl and its derivatives have become pervasive contaminants in the U.S. heroin supply. Previously, we reported a proof-of-concept vaccine designed to combat against heroin contaminated with fentanyl. Herein, we optimized the admixture vaccine and found that it surpassed the individual vaccines in every antinociceptive test, including a 10% fentanyl to heroin formulation. It is anticipated that other co-occurring drug abuse disorders may also be examined with admixture vaccines.<\/jats:p>","DOI":"10.1021\/acsomega.8b01478","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T14:38:09Z","timestamp":1537454289000},"page":"11537-11543","source":"Crossref","is-referenced-by-count":32,"title":["Improved Admixture Vaccine of Fentanyl and Heroin\nHapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated\nHeroin"],"prefix":"10.1021","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-4078","authenticated-orcid":true,"given":"Candy S.","family":"Hwang","sequence":"first","affiliation":[{"name":"The Scripps Research Institute , , 10550 N Torrey Pines Rd , ,","place":["La Jolla, California, United States, 92037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4290-3262","authenticated-orcid":true,"given":"Lauren C.","family":"Smith","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute , , 10550 N Torrey Pines Rd , ,","place":["La Jolla, California, United States, 92037"]},{"name":"The Scripps Research Institute , , 10550 N Torrey Pines Rd , ,","place":["La Jolla, California, United States, 92037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Natori","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute , , 10550 N Torrey Pines Rd , ,","place":["La Jolla, California, United States, 92037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly","family":"Ellis","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute , , 10550 N Torrey Pines Rd , ,","place":["La Jolla, California, United States, 92037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute , , 10550 N Torrey Pines Rd , ,","place":["La Jolla, California, United States, 92037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6759-4227","authenticated-orcid":true,"given":"Kim D.","family":"Janda","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute , , 10550 N Torrey Pines Rd , ,","place":["La Jolla, California, United States, 92037"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,9,20]]},"reference":[{"key":"2026090322084313700_cit1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s11916-018-0685-5","article-title":"America\u2019s Opioid Epidemic: a Comprehensive Review\nand Look into the Rising Crisis","volume":"22","author":"Ostling","year":"2018","journal-title":"Curr. 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