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Sterically stabilized and cross-linked latexes were synthesized from random copolymers of styrene (S) and 2-vinylpyridine (2VP). The pH-dependent latex-to-microgel transition and swellability were tuned based on their hydrophobic-to-hydrophilic content established by the S\/2VP ratio. The electrostatic loading of polystyrene\/poly(2-vinylpyridine) microgels [PSxP2VPy (M)] with anions such as tetrachloroaurate (AuCl4\u2013) and borate-capped Ag NPs was quantified. The PSxP2VPy (M) can load \u223c0.3 equiv of AuCl4\u2013 and the subsequent photoreduction results in Au NP-loaded PSxP2VPy (M) with NPs located throughout the structure. Loading PSxP2VPy (M) with borate-capped Ag NPs produces PSxP2VPy (M) with NPs located on the surface of the microgels, where the Ag content is set by S\/2VP. The pH-responsive SERS activity is also reported for these Ag NP-loaded microgels. Analytical enhancement factors for dissolved crystal violet are high (i.e., 109 to 1010) and are set by S\/2VP. The Ag NP-loaded microgels with \u223c80 wt % 2VP exhibited the most stable pH dependent response.<\/jats:p>","DOI":"10.1021\/acsomega.8b01561","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T11:12:25Z","timestamp":1536145945000},"page":"10572-10588","source":"Crossref","is-referenced-by-count":23,"title":["Synthesis and Characterization of Tunable, pH-Responsive\nNanoparticle\u2013Microgel Composites for Surface-Enhanced Raman\nScattering Detection"],"prefix":"10.1021","volume":"3","author":[{"given":"Tyler","family":"Curtis","sequence":"first","affiliation":[{"name":"Western Washington University , , 516 High Street , , ,","place":["Bellingham, Washington, United States, 98225"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey K.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Western Washington University , , 516 High Street , , ,","place":["Bellingham, Washington, United States, 98225"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha E.","family":"Alden","sequence":"additional","affiliation":[{"name":"Western Washington University , , 516 High Street , , ,","place":["Bellingham, Washington, United States, 98225"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Swanson","sequence":"additional","affiliation":[{"name":"Western Washington University , , 516 High Street , , ,","place":["Bellingham, Washington, United States, 98225"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Lo","sequence":"additional","affiliation":[{"name":"Western Washington University , , 516 High Street , , ,","place":["Bellingham, Washington, United States, 98225"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Knight","sequence":"additional","affiliation":[{"name":"Western Washington University , , 516 High Street , , ,","place":["Bellingham, Washington, United States, 98225"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson","family":"Silva","sequence":"additional","affiliation":[{"name":"Western Washington University , , 516 High Street , , ,","place":["Bellingham, Washington, United States, 98225"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9108-3208","authenticated-orcid":true,"given":"Byron D.","family":"Gates","sequence":"additional","affiliation":[{"name":"Simon Fraser University , , 8888 University Drive , ,","place":["Burnaby, Canada, V5A 1S6"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Emory","sequence":"additional","affiliation":[{"name":"Western Washington University , , 516 High Street , , ,","place":["Bellingham, Washington, United States, 98225"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-2069","authenticated-orcid":true,"given":"David A.","family":"Rider","sequence":"additional","affiliation":[{"name":"Western Washington University , , 516 High Street , , ,","place":["Bellingham, Washington, United States, 98225"]},{"name":"Western Washington University , , 516 High Street , , ,","place":["Bellingham, Washington, United States, 98225"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,9,5]]},"reference":[{"key":"2026090407155884600_cit1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/B978-0-12-505404-1.50009-X","volume-title":"Chemical and Biochemical\nApplications of Lasers","author":"Van Duyne","year":"1979"},{"key":"2026090407155884600_cit2","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1103\/revmodphys.57.783","article-title":"Surface-enhanced\nspectroscopy","volume":"57","author":"Moskovits","year":"1985","journal-title":"Rev. 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