{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:21:01Z","timestamp":1788355261256,"version":"build-2803163510"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100007136","name":"Ministerio de Econom\u00c3a y Competitividad","doi-asserted-by":"publisher","award":["BES-2014-069007"],"award-info":[{"award-number":["BES-2014-069007"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007136","name":"Ministerio de Econom\u00c3a y Competitividad","doi-asserted-by":"publisher","award":["MAT2013-48224-C2-1-R"],"award-info":[{"award-number":["MAT2013-48224-C2-1-R"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007136","name":"Ministerio de Econom\u00c3a y Competitividad","doi-asserted-by":"publisher","award":["MAT2013-48224-C2-2-R"],"award-info":[{"award-number":["MAT2013-48224-C2-2-R"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007136","name":"Ministerio de Econom\u00c3a y Competitividad","doi-asserted-by":"publisher","award":["MAT2017-86163-C2-1-R"],"award-info":[{"award-number":["MAT2017-86163-C2-1-R"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Joint prosthesis failure is mainly related to aseptic loosening and prosthetic joint infections, both associated with high morbidity and a substantial cost burden for patients and health systems. The development of a biomaterial capable of stimulating bone growth while minimizing bacterial adhesion would reduce the incidence of prosthetic failure. Using an in vivo rabbit model, this study evaluates the osseointegration effect of the fluorine (F)- and phosphorus (P)-doped bottle-shaped nanostructured (bNT) Ti-6Al-4V alloy and effectiveness of monitoring urine aluminum concentration to determine the presence of Pseudomonas aeruginosa infection in Ti-6Al-4V implants. Unlike chemically polished (CP) Ti-6Al-4V alloy implants, bNT Ti-6Al-4V alloy implants promoted osseointegration and showed effectiveness as a biomaterial marker. The bNT Ti-6Al-4V alloy implants were associated with a twofold increase in bone thickness and up to 15% greater bone density compared to the CP alloy. Additionally, bNT Ti-6Al-4V alloy implants allowed for discrimination between P. aeruginosa-infected and noninfected animals for 15 days postoperatively, as indicated by the decrease of aluminum concentration in urine, while this difference was only appreciable over the first 7 days when CP Ti-6Al-4V alloy implants were used. Therefore, bNT Ti-6Al-4V alloys could have clinical applications by detecting the infection and by avoiding aseptic loosening.<\/jats:p>","DOI":"10.1021\/acsomega.9b00898","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T10:33:23Z","timestamp":1562668403000},"page":"11815-11823","source":"Crossref","is-referenced-by-count":9,"title":["Urine Aluminum Concentration as a Possible Implant\nBiomarker of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    Infection Using a Fluorine- and Phosphorus-Doped Ti-6Al-4V Alloy\nwith Osseointegration Capacity"],"prefix":"10.1021","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4002-1944","authenticated-orcid":true,"given":"John-Jairo","family":"Aguilera-Correa","sequence":"first","affiliation":[{"name":"IIS-Fundacio\u0301n Jimenez Diaz , , UAM. Av. Reyes Cato\u0301licos, 2 , ,","place":["Madrid, Spain, 28040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u0301lvaro","family":"Aun\u0303o\u0301n","sequence":"additional","affiliation":[{"name":"Fundacio\u0301n Jime\u0301nez Di\u0301az University Hospital , , Av. Reyes Cato\u0301licos, 2 , ,","place":["Madrid, Spain, 28040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Boiza-Sa\u0301nchez","sequence":"additional","affiliation":[{"name":"Fundacio\u0301n Jime\u0301nez Di\u0301az University Hospital , , Av. Reyes Cato\u0301licos, 2 , ,","place":["Madrid, Spain, 28040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Mahillo-Ferna\u0301ndez","sequence":"additional","affiliation":[{"name":"Fundacio\u0301n Jime\u0301nez Di\u0301az University Hospital , , Av. Reyes Cato\u0301licos, 2 , ,","place":["Madrid, Spain, 28040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aranzazu","family":"Mediero","sequence":"additional","affiliation":[{"name":"IIS-Fundacio\u0301n Jimenez Diaz , , UAM. Av. Reyes Cato\u0301licos, 2 , ,","place":["Madrid, Spain, 28040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Eguibar-Bla\u0301zquez","sequence":"additional","affiliation":[{"name":"IIS-Fundacio\u0301n Jimenez Diaz , , UAM. Av. Reyes Cato\u0301licos, 2 , ,","place":["Madrid, Spain, 28040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Conde","sequence":"additional","affiliation":[{"name":"National Center for Metallurgical Research (CENIM-CSIC) , , Av. Gregorio del Amo, 8 , ,","place":["Madrid, Spain, 28040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u0301a-A\u0301ngeles","family":"Arenas","sequence":"additional","affiliation":[{"name":"National Center for Metallurgical Research (CENIM-CSIC) , , Av. Gregorio del Amo, 8 , ,","place":["Madrid, Spain, 28040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Jose\u0301","family":"de-Damborenea","sequence":"additional","affiliation":[{"name":"National Center for Metallurgical Research (CENIM-CSIC) , , Av. Gregorio del Amo, 8 , ,","place":["Madrid, Spain, 28040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301","family":"Cordero-Ampuero","sequence":"additional","affiliation":[{"name":"University Hospital La Princesa , , c\/Diego de Leo\u0301n 62 , ,","place":["Madrid, Spain, 28006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Esteban","sequence":"additional","affiliation":[{"name":"IIS-Fundacio\u0301n Jimenez Diaz , , UAM. Av. Reyes Cato\u0301licos, 2 , ,","place":["Madrid, Spain, 28040"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,7,9]]},"reference":[{"key":"2026090208553587000_cit1","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1056\/nejmcp0905029","article-title":"Infection Associated with Prosthetic\nJoints","volume":"361","author":"Del Pozo","year":"2009","journal-title":"N. Engl. J. 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Ther."},{"key":"2026090208553587000_cit4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.11138\/ccmbm\/2013.10.2.097","article-title":"Painful prosthesis:\napproaching the patient with persistent\npain following total hip and knee arthroplasty","volume":"10","author":"Piscitelli","year":"2013","journal-title":"Clin. Cases Miner. Bone Metab."},{"key":"2026090208553587000_cit5","doi-asserted-by":"publisher","first-page":"e01910","DOI":"10.1128\/mbio.01910-14","article-title":"Clinical characteristics\nand outcomes\nof prosthetic joint infection caused by small colony variant staphylococci","volume":"5","author":"Tande","year":"2014","journal-title":"mBio"},{"key":"2026090208553587000_cit6","doi-asserted-by":"publisher","first-page":"732e1","DOI":"10.1016\/j.cmi.2016.05.004","article-title":"Time trends in the\naetiology of prosthetic joint infections: a multicentre cohort study","volume":"22","author":"Benito","year":"2016","journal-title":"Clin. Microbiol. 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Microbiol.\nInfect."},{"key":"2026090208553587000_cit8a","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1086\/605593","article-title":"Gram-Negative Prosthetic\nJoint Infections:\nRisk Factors and Outcome of Treatment","volume":"49","author":"Hsieh","year":"2009","journal-title":"Clin.\nInfect. Dis."},{"key":"2026090208553587000_cit8b","doi-asserted-by":"publisher","first-page":"25","DOI":"10.7150\/jbji.15722","article-title":"Pseudomonas\nProsthetic Joint Infections: A Review of 102 Episodes","volume":"1","author":"Shah","year":"2016","journal-title":"J Bone Jt. Infect."},{"key":"2026090208553587000_cit9a","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jmbbm.2015.05.008","article-title":"Influence of fluoride content and\npH on corrosion and\ntribocorrosion behaviour of Ti13Nb13Zr alloy in oral environment","volume":"49","author":"Golvano","year":"2015","journal-title":"J. Mech. Behav. Biomed. 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Vol."},{"key":"2026090208553587000_cit13","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1016\/0142-9612(96)00023-3","article-title":"Titanium\nserum and urine levels in\nrabbits with a titanium implant in the absence of wear","volume":"17","author":"Bianco","year":"1996","journal-title":"Biomaterials"},{"key":"2026090208553587000_cit14","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1007\/s00216-011-5232-8","article-title":"Titanium release in serum of patients with different\nbone fixation implants and its interaction with serum biomolecules\nat physiological levels","volume":"401","author":"Nuevo-Ordo\u0301n\u0303ez","year":"2011","journal-title":"Anal. Bioanal. 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Musculoskeletal Neuronal\nInteract."},{"key":"2026090208553587000_cit21","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/clr.12798","article-title":"Pectin nanocoating of titanium implant\nsurfaces - an experimental study in rabbits","volume":"28","author":"Gurzawska","year":"2017","journal-title":"Clin. Oral Implant. Res."},{"key":"2026090208553587000_cit22","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s13770-017-0106-6","article-title":"Osteogenic\nNanofibrous Coated Titanium Implant Results in Enhanced Osseointegration:\nIn Vivo Preliminary Study in a Rabbit Model","volume":"15","author":"Das","year":"2018","journal-title":"Tissue Eng. Regener. 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Adv."},{"key":"2026090208553587000_cit28","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1039\/b314329p","article-title":"The biological\nbehaviour and bioavailability of aluminium in man, with special reference\nto studies employing aluminium-26 as a tracer: review and study update","volume":"6","author":"Priest","year":"2004","journal-title":"J Environ Monit"},{"key":"2026090208553587000_cit29a","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1039\/c3em00374d","article-title":"Human exposure to aluminium","volume":"15","author":"Exley","year":"2013","journal-title":"Environ. Sci. Process. 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Res."},{"key":"2026090208553587000_cit32","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jtemb.2013.12.002","article-title":"If exposure\nto aluminium in antiperspirants presents health risks, its content\nshould be reduced","volume":"28","author":"Pineau","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"key":"2026090208553587000_cit33","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/9780470514306.ch3","article-title":"Dietary\nand other sources of aluminium intake","volume":"169","author":"Greger","year":"1992","journal-title":"Ciba\nFound. 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Translat."},{"key":"2026090208553587000_cit36","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1016\/j.electacta.2010.11.069","article-title":"Morphologies of\nnanostructured TiO2\ndoped with F on Ti-6Al-4V alloy","volume":"56","author":"Matykina","year":"2011","journal-title":"Electrochim.\nActa"},{"key":"2026090208553587000_cit37","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/jor.1100140423","article-title":"Influence\nof bacterial strains on\nbone infection","volume":"14","author":"Cordera","year":"1996","journal-title":"J. Orthop. Res."},{"key":"2026090208553587000_cit38","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.2106\/00004623-198567080-00015","article-title":"The influence\nof skeletal implants on incidence of infection. Experiments in a canine\nmodel","volume":"67","author":"Petty","year":"1985","journal-title":"J. Bone Jt. Surg., Am. Vol."},{"key":"2026090208553587000_cit39","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1128\/jcm.01762-07","article-title":"Evaluation\nof quantitative analysis\nof cultures from sonicated retrieved orthopedic implants in diagnosis\nof orthopedic infection","volume":"46","author":"Esteban","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"2026090208553587000_cit40","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/j.jinorgbio.2007.06.006","article-title":"A sensitive\nstain\nfor aluminum in undecalcified cancellous bone","volume":"101","author":"Walton","year":"2007","journal-title":"J. Inorg. 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