{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:37:01Z","timestamp":1790519821565,"version":"4.1.0"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nipah virus (NiV) is an emerging zoonotic pathogen, reported for the recent severe outbreaks of encephalitis and respiratory illness in humans and animals, respectively. Many antiviral drugs have been discovered to inhibit this pathogen, but none of them were that much efficient. To overcome the complications associated with this severe pathogenic virus, we have designed a multi-epitope subunit vaccine using computational immunology strategies. Identification of structural and nonstructural proteins of Nipah virus assisted in the vaccine designing. The selected proteins are known to be involved in the survival of the virus. The antigenic binders (B-cell, HTL, and CTL) from the selected proteins were prognosticated. These antigenic binders will be able to generate the humoral as well as cell-mediated immunity. All the epitopes were united with the help of suitable linkers and with an adjuvant at the N-terminal of the vaccine, for the enhancement of immunogenicity. The physiological characterization, along with antigenicity and allergenicity of the designed vaccine candidates, was estimated. The 3D structure prediction and its validation were performed. The validated vaccine model was then docked and simulated with the TLR-3 receptor to check the stability of the docked complex. This next-generation approach will provide a new vision for the development of a high immunogenic vaccine against the NiV.<\/jats:p>","DOI":"10.1021\/acsomega.9b00944","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T08:53:23Z","timestamp":1565168003000},"page":"13069-13079","source":"Crossref","is-referenced-by-count":71,"title":["Strategic Development of a Next-Generation Multi-Epitope\nVaccine To Prevent Nipah Virus Zoonotic Infection"],"prefix":"10.1021","volume":"4","author":[{"given":"Rupal","family":"Ojha","sequence":"first","affiliation":[{"name":"Central University of Rajasthan , , NH-8, Bandarsindri , Kishangarh, , ,","place":["Ajmer, Rajasthan, India, 305817"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Pareek","sequence":"additional","affiliation":[{"name":"Central University of Rajasthan , , NH-8, Bandarsindri , Kishangarh, , ,","place":["Ajmer, Rajasthan, India, 305817"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan K.","family":"Pandey","sequence":"additional","affiliation":[{"name":"Central University of Rajasthan , , NH-8, Bandarsindri , Kishangarh, , ,","place":["Ajmer, Rajasthan, India, 305817"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaneswar","family":"Prusty","sequence":"additional","affiliation":[{"name":"Central University of Rajasthan , , NH-8, Bandarsindri , Kishangarh, , ,","place":["Ajmer, Rajasthan, India, 305817"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6510-0596","authenticated-orcid":true,"given":"Vijay K.","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Central University of Rajasthan , , NH-8, Bandarsindri , Kishangarh, , ,","place":["Ajmer, Rajasthan, India, 305817"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,8,7]]},"reference":[{"key":"2026090201501728700_cit1","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1099\/vir.0.82427-0","article-title":"Inhibition of henipavirus infection\nby Nipah virus attachment glycoprotein occurs without cell-surface\ndownregulation of ephrin-B2 or ephrin-B3","volume":"88","author":"Sawatsky","year":"2007","journal-title":"J.\nGen. Virol."},{"key":"2026090201501728700_cit2","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1086\/647951","article-title":"Transmission\nof human infection with\nNipah Virus","volume":"49","author":"Luby","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"2026090201501728700_cit3","unstructured":"Nipah Virus (http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/nipah-virus)."},{"key":"2026090201501728700_cit4","unstructured":"NCDC.\n          .  Nipah Virus Infection (https:\/\/ncdc.gov.in\/showfile.php?lid=229)."},{"key":"2026090201501728700_cit5","unstructured":"WHO.\n          .  Nipah virus \u2013 India ( https:\/\/www.who.int\/csr\/don\/07-august-2018-nipah-virus-india\/en\/)."},{"key":"2026090201501728700_cit6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002024","article-title":"Comparison of the pathogenicity\nof Nipah virus isolates\nfrom Bangladesh and Malaysia in the Syrian hamster","volume":"7","author":"DeBuysscher","year":"2013","journal-title":"PLoS Neglected Trop. Dis."},{"key":"2026090201501728700_cit7","first-page":"20","article-title":"Nipah virus:\nAn\nupdate on prevention and control strategies with special reference\nto the latest outbreak in India","author":"Ganguly","year":"2018","journal-title":"Int. J. Vet.\nSci. Anim. Husb."},{"key":"2026090201501728700_cit8","doi-asserted-by":"publisher","first-page":"242ra82","DOI":"10.1126\/scitranslmed.3008929","article-title":"Therapeutic\nTreatment of Nipah Virus Infection in Nonhuman Primates with a Neutralizing\nHuman Monoclonal Antibody","volume":"6","author":"Geisbert","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"2026090201501728700_cit9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.antiviral.2013.06.012","article-title":"A treatment\nfor and vaccine against the deadly Hendra and Nipah viruses","volume":"100","author":"Broder","year":"2013","journal-title":"Antiviral Res."},{"key":"2026090201501728700_cit10","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1002\/jcb.26719","article-title":"Exploring\nsand fly salivary proteins to design multi-epitope\nsubunit vaccine to fight against visceral leishmaniasis","volume":"120","author":"Pandey","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"2026090201501728700_cit11","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1038\/s41598-018-19456-1","article-title":"Novel immunoinformatics approaches\nto design multi-epitope subunit vaccine for malaria by investigating\nanopheles salivary protein","volume":"8","author":"Pandey","year":"2018","journal-title":"Sci. Rep."},{"key":"2026090201501728700_cit12","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1080\/07391102.2018.1484815","article-title":"Exploratory algorithm to devise multi-epitope\nsubunit vaccine by investigating Leishmania donovanimembrane proteins","author":"Khatoon","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"key":"2026090201501728700_cit13","doi-asserted-by":"publisher","first-page":"7082","DOI":"10.1002\/jcb.27979","article-title":"Epitope-based immunoinformatics approach\non RNA-dependent RNA polymerase (RdRp) protein complex of Nipah virus\n(NiV)","volume":"120","author":"Ravichandran","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"2026090201501728700_cit14","doi-asserted-by":"publisher","first-page":"678664","DOI":"10.1101\/678664","article-title":"Epitope - based peptide vaccine against glycoprotein\nG of Nipah henipavirus using immunoinformatics approaches","author":"Mohammed","year":"2019","journal-title":"bioRxiv"},{"key":"2026090201501728700_cit15","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1038\/s41598-019-40833-x","article-title":"In-silico design of a multi-epitope vaccine candidate\nagainst onchocerciasis and related filarial diseases","volume":"9","author":"Shey","year":"2019","journal-title":"Sci. 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Neurol."},{"key":"2026090201501728700_cit24","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1099\/vir.0.017269-0","article-title":"Combined chloroquine\nand ribavirin treatment does not prevent death in a hamster model\nof Nipah and Hendra virus infection","volume":"91","author":"Freiberg","year":"2010","journal-title":"J. Gen.\nVirol."},{"key":"2026090201501728700_cit25","doi-asserted-by":"publisher","first-page":"146ra107","DOI":"10.1126\/scitranslmed.3004241","article-title":"A Hendra\nvirus G glycoprotein subunit vaccine protects African green monkeys\nfrom Nipah virus challenge","volume":"4","author":"Bossart","year":"2012","journal-title":"Sci. Transl. 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Virol."},{"key":"2026090201501728700_cit36","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.virol.2010.05.005","article-title":"Characterization\nof the antiviral\nand inflammatory responses against Nipah virus in endothelial cells\nand neurons","volume":"404","author":"Lo","year":"2010","journal-title":"Virology"},{"key":"2026090201501728700_cit37","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1006\/viro.2000.0340","article-title":"Molecular characterization\nof Nipah\nvirus, a newly emergent paramyxovirus","volume":"271","author":"Harcourt","year":"2000","journal-title":"Virology"},{"key":"2026090201501728700_cit38","doi-asserted-by":"publisher","first-page":"7631","DOI":"10.1002\/jcb.27110","article-title":"Designing\nB-and T-cell multi-epitope based subunit vaccine using immunoinformatics\napproach to control Zika virus infection","volume":"119","author":"Kumar Pandey","year":"2018","journal-title":"J.\nCell. Biochem."},{"key":"2026090201501728700_cit39","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3201\/eid1802.111492","article-title":"Characterization\nof Nipah virus from outbreaks in Bangladesh, 2008-2010","volume":"18","author":"Lo","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"2026090201501728700_cit40","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s12026-013-8428-5","article-title":"Nasal delivery\nof PLG microparticle\nencapsulated defensin peptides adjuvanted gp41 antigen confers strong\nand long-lasting immunoprotective response against HIV-1","volume":"58","author":"Mohan","year":"2014","journal-title":"Immunol. Res."},{"key":"2026090201501728700_cit41","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/prot.21078","article-title":"Prediction of\ncontinuous B-cell epitopes in an antigen\nusing recurrent neural network","volume":"65","author":"Saha","year":"2006","journal-title":"Proteins"},{"key":"2026090201501728700_cit42","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1016\/j.vaccine.2018.03.042","article-title":"Immunoinformatics\napproaches to design a novel multi-epitope subunit vaccine against\nHIV infection","volume":"36","author":"Pandey","year":"2018","journal-title":"Vaccine"},{"key":"2026090201501728700_cit43","doi-asserted-by":"publisher","first-page":"278","DOI":"10.3389\/fimmu.2017.00278","article-title":"The immune epitope database and analysis\nresource in epitope discovery and synthetic vaccine design","volume":"8","author":"Fleri","year":"2017","journal-title":"Front. 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