{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:13:44Z","timestamp":1788362024640,"version":"build-2803163510"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["JUSRP11906"],"award-info":[{"award-number":["JUSRP11906"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2016YFD0401204"],"award-info":[{"award-number":["2016YFD0401204"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["31772069"],"award-info":[{"award-number":["31772069"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["YZ201709"],"award-info":[{"award-number":["YZ201709"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["CX(17)10032"],"award-info":[{"award-number":["CX(17)10032"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["JUFSTR20180303"],"award-info":[{"award-number":["JUFSTR20180303"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ferric ions (Fe3+ ions) and l-cysteine (( l-Cys) in the human body have always played an irreplaceable role in biological processes, and overload or deficiency of Fe3+ ions and l-Cys in the biological system leads to various diseases. In this work, N,S-co-doped red-emitting carbon dots (R-CDs) were synthesized by a facile hydrothermal method. Because the doping of N and S gives a unique functional group distribution on the surface of R-CDs, it can be complexed with Fe3+ ions to construct an energy transfer quenching system. However, the presence of l-Cys competitively binds to Fe3+ ions, thus resulting in the photoluminescence recovery of R-CDs. Therefore, a \u201cswitch-on\u201d dual function sensing platform has successfully been developed based on R-CDs for rapid identification and quantification of Fe3+ ions and l-Cys. The linear detection range of Fe3+ ions is 0\u201330 \u03bcM (limit of detection (LOD): 0.27 \u03bcM) and that of l-Cys is 0\u201324 \u03bcM (LOD: 0.14 \u03bcM). The sensor platform was used to detect Fe3+ ions and l-Cys in human serum samples with satisfactory results. Compared with traditional detection methods, this method is more time-saving and efficient and can be completed in 3 min. It is worth mentioning that the R-CDs not only has high optical stability but also has negligible cytotoxicity and has been successfully applied to in vitro\/vivo imaging, indicating that R-CDs have excellent tissue penetration and biomarker potential. More interestingly, the switch-on fluorescence behavior for stepwise detection of Fe3+ ions and l-Cys can also be observed in cell imaging, which provides the possibility of visual detection of the probe to be applied in vivo.<\/jats:p>","DOI":"10.1021\/acsomega.9b01019","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T09:51:13Z","timestamp":1563961873000},"page":"12575-12583","source":"Crossref","is-referenced-by-count":56,"title":["Red-Emissive Carbon Dots for \u201cSwitch-On\u201d\nDual Function Sensing Platform Rapid Detection of Ferric Ions and\n                    <scp>l<\/scp>\n                    -Cysteine in Living Cells"],"prefix":"10.1021","volume":"4","author":[{"given":"Xingxing","family":"Yang","sequence":"first","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangchao","family":"Cui","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Ren","sequence":"additional","affiliation":[{"name":"Shaanxi University of Technology , , , ,","place":["Hanzhong, Shaanxi, People\u2019s Republic of China, 723000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiadi","family":"Sun","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ji","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuwei","family":"Pi","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinzhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1528-8601","authenticated-orcid":true,"given":"Xiulan","family":"Sun","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"key":"2026090210231011900_cit1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.bios.2016.05.046","article-title":"A dendrimer-based highly sensitive\nand selective fluorescence-quenching sensor for Fe3+ both\nin solution and as film","volume":"85","author":"Li","year":"2016","journal-title":"Biosens. 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