{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:19:14Z","timestamp":1788326354068,"version":"build-2803163510"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A high-yielding, green, and fast synthesis of alkyl 2-substituted {[(alkylsulfanyl)carbonothioyl]amino}acetate-type compounds is described. The one-pot, three-component condensation of alkyl 2-aminoesters, carbon disulfide, and electron-deficient olefins was the key reaction to be developed. The products were obtained easily and efficiently, with good overall yields after two steps (79\u201391%), employing short reaction times, without the use of a catalyst, and ultrasonic irradiation in water. This procedure was exploited to produce antifungals against the phytopathogenic fungus Fusarium oxysporum. Some synthesized compounds exhibited good performance as mycelial growth inhibitors (IC50 &amp;lt; 80 \u03bcM). Structural and antifungal datasets were integrated to explore the comprehensive three-dimensional quantitative structure\u2013activity relationship (3D-QSAR) using comparative molecular field analysis (CoMFA) and explain the observed activity. This integration resulted in an excellent CoMFA model (r2 = 0.812; q2 = 0.771) after substructure-based alignment. According to this model, synthesized compounds possessing steric bulky electron-withdrawing groups in the dithiocarbamate moiety can be considered as promising F. oxysporum inhibitors.<\/jats:p>","DOI":"10.1021\/acsomega.9b01098","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T11:22:13Z","timestamp":1565608933000},"page":"13710-13720","source":"Crossref","is-referenced-by-count":12,"title":["Ultrasound-Assisted Synthesis, Antifungal Activity\nagainst\n                    <i>Fusarium oxysporum<\/i>\n                    , and Three-Dimensional\nQuantitative Structure\u2013Activity Relationship of\n                    <i>N<\/i>\n                    ,\n                    <i>S<\/i>\n                    -Dialkyl Dithiocarbamates Derived from\n2-Amino Acids"],"prefix":"10.1021","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5156-8200","authenticated-orcid":true,"given":"Diego","family":"Quiroga","sequence":"first","affiliation":[{"name":"Universidad Militar Nueva Granada , , Campus Nueva Granada, ,","place":["Cajica\u0301, Colombia, 250247"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3366-022X","authenticated-orcid":true,"given":"Lili Dahiana","family":"Becerra","sequence":"additional","affiliation":[{"name":"Universidad Militar Nueva Granada , , Campus Nueva Granada, ,","place":["Cajica\u0301, Colombia, 250247"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3553-9749","authenticated-orcid":true,"given":"Ericsson","family":"Coy-Barrera","sequence":"additional","affiliation":[{"name":"Universidad Militar Nueva Granada , , Campus Nueva Granada, ,","place":["Cajica\u0301, Colombia, 250247"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"2026090200214023300_cit1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.fgb.2014.10.012","article-title":"Crop-destroying\nfungal and oomycete pathogens challenge\nfood security","volume":"74","author":"Bebber","year":"2015","journal-title":"Fungal Genet. 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