{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:14:26Z","timestamp":1788351266210,"version":"build-2803163510"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31800283"],"award-info":[{"award-number":["31800283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2017YFD0201300"],"award-info":[{"award-number":["2017YFD0201300"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030310283"],"award-info":[{"award-number":["2017A030310283"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bacterial wilt caused by Ralstonia solanacearum is one of the most destructive bacterial diseases in agriculture. There is no effective control method, although chemical pesticides are used to prevent this disease, but they may lead to serious problems of environmental pollution. Natural products from plants can be rich and environmentally friendly sources for a broad spectrum biological control of bacteria. This study focuses on the pericarp of mangosteen (Garcinia mangostana) using bioactivity-guided analysis of different fractions and liquid chromatography\u2013mass spectrometry combined with multivariate analysis to determine markers of active fractions. Six prenyl xanthones, including two new xanthones, garcimangosxanthones H and I, were isolated and identified by NMR and HRESIMS. The biomarker \u03b3-mangostin displayed significant activity against the phytopathogen R. solanacearum with an IC50 of 34.7 \u00b1 1.5 \u03bcg\/mL; \u03b3-mangostin affected the bacterial morphology at a concentration of 16.0 \u03bcg\/mL as seen with a scanning electron microscope image, and it significantly repressed the virulence-associated genes HrpB, FihD, and PilT of R. solanacearum. \u03b3-Mangostin also reduced the symptoms of bacterial wilt disease effectively that is caused by R. solanacearum in tomato and tobacco seedlings in vitro. These results suggested that the use of \u03b3-mangostin from the mangosteen pericarp against R. solanacearum may be used as a natural bacteriostatic agent in agriculture.<\/jats:p>","DOI":"10.1021\/acsomega.9b02746","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T08:27:43Z","timestamp":1577435263000},"page":"334-343","source":"Crossref","is-referenced-by-count":21,"title":["Identification\nof Xanthones from the Mangosteen Pericarp that Inhibit the Growth\nof\n                    <i>Ralstonia solanacearum<\/i>"],"prefix":"10.1021","volume":"5","author":[{"given":"Ping","family":"Li","sequence":"first","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, People\u2019s Republic of China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyan","family":"Yang","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, People\u2019s Republic of China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolin","family":"Tang","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, People\u2019s Republic of China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, People\u2019s Republic of China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zepeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Tobacco Shaoguan Co. Ltd. , , ,","place":["Shaoguan, Guangdong, People\u2019s Republic of China, 512000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jili","family":"Zhang","sequence":"additional","affiliation":[{"name":"China Tobacco Guangxi Industrial Co. Ltd. , , ,","place":["Nanning, Guangxi, People\u2019s Republic of China, 530001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Wei","sequence":"additional","affiliation":[{"name":"China Tobacco Guangxi Industrial Co. Ltd. , , ,","place":["Nanning, Guangxi, People\u2019s Republic of China, 530001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Sun","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, People\u2019s Republic of China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8597-9841","authenticated-orcid":true,"given":"Jian","family":"Yan","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, People\u2019s Republic of China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"key":"2026090207252968900_cit1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/mpp.12079","article-title":"Ralstonia solanacearum type III secretion system effector Rip36 induces\na hypersensitive response in the nonhost wild eggplant Solanum torvum","volume":"15","author":"Nahar","year":"2014","journal-title":"Mol. Plant Pathol."},{"key":"2026090207252968900_cit2","first-page":"9","article-title":"The current bacterial wilt situation: a global overview","volume-title":"Bacterial wilt the disease & the Ralstonia Solanacearum\nspecies complex","author":"Elphinstone","year":"2005"},{"key":"2026090207252968900_cit3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1264\/jsme2.ME14144","article-title":"Recent trends in control\nmethods for bacterial wilt diseases caused by Ralstonia solanacearum","volume":"30","author":"Yuliar","year":"2015","journal-title":"Microbes Environ."},{"key":"2026090207252968900_cit4","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.3389\/fpls.2017.01549","article-title":"Bacterial wilt in China:\nHistory, current status, and future perspectives","volume":"8","author":"Jiang","year":"2017","journal-title":"Front. Plant Sci."},{"key":"2026090207252968900_cit5","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s11101-017-9512-6","article-title":"Phytochemical biopesticides: Some recent developments","volume":"16","author":"Walia","year":"2017","journal-title":"Phytochem. Rev."},{"key":"2026090207252968900_cit6","first-page":"15","article-title":"Activity screening\nof fifty-two species of tropical officinals against tobacco green\nblight (Ralstonia solanacearum) in vitro","volume":"31","author":"Jiang","year":"2011","journal-title":"J. Microbiol."},{"key":"2026090207252968900_cit7","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1094\/PDIS.2003.87.4.423","article-title":"Effects of plant\nessential oils on Ralstonia solanacearum population\ndensity and bacterial wilt incidence in tomato","volume":"87","author":"Pradhanang","year":"2003","journal-title":"Plant Dis."},{"key":"2026090207252968900_cit8","doi-asserted-by":"publisher","first-page":"103604","DOI":"10.1016\/j.micpath.2019.103604","article-title":"Antibacterial activity of three essential oils and\nsome monoterpenes against Ralstonia solanacearum phylotype\nII isolated from potato","volume":"135","author":"Mohamed","year":"2019","journal-title":"Microb. 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Crops Prod."},{"key":"2026090207252968900_cit21","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1248\/cpb.51.857","article-title":"Antimycobacterial activity of prenylated\nxanthones from the fruits of Garcinia mangostana","volume":"51","author":"Suksamrarn","year":"2003","journal-title":"Chem. Pharm. Bull."},{"key":"2026090207252968900_cit22","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1016\/j.phytochem.2005.03.010","article-title":"Xanthones from Garcinia smeathmannii (Oliver) and their antimicrobial activity","volume":"66","author":"Komguem","year":"2005","journal-title":"Phytochemistry"},{"key":"2026090207252968900_cit23","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1021\/np010566g","article-title":"Xanthones\nfrom the green fruit hulls of Garcinia mangostana","volume":"65","author":"Suksamrarn","year":"2002","journal-title":"J. Nat. 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Phytopathol."},{"key":"2026090207252968900_cit26","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1365-2958.2004.04118.x","article-title":"Inventory and functional\nanalysis of the large Hrp regulon in Ralstonia solanacearum: identification of novel effector proteins translocated to plant\nhost cells through the type III secretion system","volume":"53","author":"Cunnac","year":"2004","journal-title":"Mol. Microbiol."},{"key":"2026090207252968900_cit27","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1016\/j.febslet.2005.02.058","article-title":"Control of theRalstonia solanacearumType III secretion\nsystem (Hrp) genes by the global virulence regulator PhcAControl of\nthe Ralstonia solanacearum Type III secretion system\n(Hrp) genes by the global virulence regulator PhcA","volume":"579","author":"Genin","year":"2005","journal-title":"FEBS Lett."},{"key":"2026090207252968900_cit28","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s11104-014-2293-4","article-title":"Proteomic characterization of silicon-mediated\nresistance against Ralstonia solanacearum in tomato","volume":"387","author":"Chen","year":"2015","journal-title":"Plant Soil"},{"key":"2026090207252968900_cit29","doi-asserted-by":"publisher","first-page":"3363","DOI":"10.1021\/jf500361e","article-title":"Antimicrobial\nactivities of novel mannosyl lipids isolated from the biocontrol fungus Simplicillium lamellicola BCP against phytopathogenic bacteria","volume":"62","author":"Le Dang","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"2026090207252968900_cit30","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.3390\/molecules21111501","article-title":"Resveratrol and coumarin: Novel agricultural antibacterial agent\nagainst Ralstonia solanacearum in vitro and in vivo","volume":"21","author":"Chen","year":"2016","journal-title":"Molecules"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.9b02746","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/5\/1\/334\/67707685\/acsomega.9b02746.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/5\/1\/334\/67707685\/acsomega.9b02746.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:25:34Z","timestamp":1788348334000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/5\/1\/334\/872879\/Identification-of-Xanthones-from-the-Mangosteen"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,27]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12,27]]},"published-print":{"date-parts":[[2020,1,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.9b02746","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,27]]}}}