{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:19:55Z","timestamp":1788351595921,"version":"build-2803163510"},"reference-count":31,"publisher":"American Chemical Society (ACS)","issue":"24","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18fk0108054"],"award-info":[{"award-number":["JP18fk0108054"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H04420"],"award-info":[{"award-number":["JP18H04420"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H02766"],"award-info":[{"award-number":["JP19H02766"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K22971"],"award-info":[{"award-number":["JP19K22971"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Effective screening methods for the development of glycopolymers as molecular recognition materials are desirable for the discovery of novel biofunctional materials. A glycopolymer library was prepared to obtain guidelines for the design of glycopolymers for the recognition of cholera toxin B subunits (CTB). Glycopolymers with varying ratios of hydrophobic and sugar units were synthesized by reversible addition fragmentation chain transfer polymerization. N-tert-Butylacrylamide, N-phenylacrylamide, and N-cyclohexylacrylamide as hydrophobic units were copolymerized in the polymer backbone, and galactose, which contributes to CTB recognition, was introduced into the side chains by \u201cpost-click\u201d chemistry. The thiol-terminated glycopolymers were immobilized on a gold surface. The polymer immobilization substrate was analyzed in terms of interaction with galactose recognition proteins (CTB, peanut agglutinin, and Ricinus communis agglutinin I) using surface plasmon resonance imaging. The polymers with high ratios of sugar and hydrophobic units had the strongest interactions with the CTB, which was different from the trend with peanut agglutinin and Ricinus communis agglutinin I. The binding constant of the CTB with the glycopolymer with hydrophobic units was 4.1 \u00d7 106 M\u20131, which was approximately eight times larger than that of the polymer without hydrophobic units. A correlation was observed between the log P value and the binding constant, indicating that the hydrophobic interaction played an important role in binding. New guidelines for the design of recognition materials were obtained by our screening method.<\/jats:p>","DOI":"10.1021\/acsomega.9b02877","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T10:57:30Z","timestamp":1574765850000},"page":"20690-20696","source":"Crossref","is-referenced-by-count":10,"title":["Screening of a Glycopolymer Library of GM1 Mimics\nContaining Hydrophobic Units Using Surface Plasmon Resonance Imaging"],"prefix":"10.1021","volume":"4","author":[{"given":"Yuri","family":"Kimoto","sequence":"first","affiliation":[{"name":"Kyushu University , , 744 Motooka Nishi-ku , ,","place":["Fukuoka, Japan, 819-0395"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhei","family":"Terada","sequence":"additional","affiliation":[{"name":"Kyushu University , , 744 Motooka Nishi-ku , ,","place":["Fukuoka, Japan, 819-0395"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9628-6979","authenticated-orcid":true,"given":"Yu","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Kyushu University , , 744 Motooka Nishi-ku , ,","place":["Fukuoka, Japan, 819-0395"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8590-6079","authenticated-orcid":true,"given":"Yoshiko","family":"Miura","sequence":"additional","affiliation":[{"name":"Kyushu University , , 744 Motooka Nishi-ku , ,","place":["Fukuoka, Japan, 819-0395"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"2026090207484103200_cit1","volume-title":"Introduction to Glycobiology","author":"Taylor","year":"2002","edition":"2"},{"key":"2026090207484103200_cit2","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1021\/cr0004310","article-title":"Synthesis\nof glycoproteins","volume":"102","author":"Davis","year":"2002","journal-title":"Chem. 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