{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T20:41:59Z","timestamp":1793565719506,"version":"4.5.0"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"25","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Poly-l-lactide-co-\u03b5-caprolactone (PLCL) is a unique polymer containing both polylactic acid and poly-\u03b5-caprolactone (PCL) chain units, and thus it has better flexible and biodegradable properties. Based on these unique properties of PLCL, we have developed balloons that are now widely used in treating major medical problems [Biomaterials\u00a02016,\u00a0105, 109\u2013116]. One of the most important considerations needed for balloons is to ensure that the material properties remain similar after undergoing ethylene oxide (EtO) or gamma (\u03b3-) sterilization treatments. From the biotechnological point of view, we focused on analyzing the vital molecular properties of the PLCL material after sterilization, such as changes in crystallinity, molecular weight distributions (Mw, Mn, and polydispersity index), and inherent viscosity (\u03b7). Analysis of the data reveals that EtO sterilization does not engender any change in crystallinity, melting temperature (Tm), molecular weights, and \u03b7 of the polymer. On the contrary, \u03b3-radiations induce chain scission and consequential decrease of \u223c33 and \u223c15% in molecular weights and \u03b7 values, respectively. Based on our observations, we recommend EtO sterilization instead of \u03b3-radiation for PLCL. This ensures prolonged stability of the polymer against degradation in a biological environment, long-shelf life, and absolute assurance that balloon failures do not occur after implantation.<\/jats:p>","DOI":"10.1021\/acsomega.9b02889","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T14:07:24Z","timestamp":1575382044000},"page":"21319-21326","source":"Crossref","is-referenced-by-count":37,"title":["Effect of Ethylene\nOxide and Gamma (\u03b3-)\nSterilization on the Properties of a PLCL Polymer Material in Balloon\nImplants"],"prefix":"10.1021","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2673-7118","authenticated-orcid":true,"given":"Moran","family":"Haim Zada","sequence":"first","affiliation":[{"name":"The Hebrew University of Jerusalem , , ,","place":["Jerusalem, Israel, 91120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awanish","family":"Kumar","sequence":"additional","affiliation":[{"name":"The Hebrew University of Jerusalem , , ,","place":["Jerusalem, Israel, 91120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Elmalak","sequence":"additional","affiliation":[{"name":"The Hebrew University of Jerusalem , , ,","place":["Jerusalem, Israel, 91120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3589-8186","authenticated-orcid":true,"given":"Guy","family":"Mechrez","sequence":"additional","affiliation":[{"name":"ARO , , 68 HaMaccabim Road , ,","place":["Rishon LeZion, Israel, 7505101"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2241-7726","authenticated-orcid":true,"given":"Abraham J.","family":"Domb","sequence":"additional","affiliation":[{"name":"The Hebrew University of Jerusalem , , ,","place":["Jerusalem, Israel, 91120"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"key":"2026090210114209100_cit1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.biomaterials.2016.08.008","article-title":"Biodegradable inflatable balloons\nfor tissue separation","volume":"105","author":"Basu","year":"2016","journal-title":"Biomaterials"},{"key":"2026090210114209100_cit2","doi-asserted-by":"publisher","first-page":"e605","DOI":"10.1016\/j.eats.2014.06.017","article-title":"Subacromial\nSpacer Placement for Protection of Rotator Cuff Repair","volume":"3","author":"Szo\u0308llo\u0308sy","year":"2014","journal-title":"Arthrosc. 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