{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:26:28Z","timestamp":1787232388841,"version":"build-2736575974"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"13","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100005989","name":"Ministrstvo za Izobra?evanje, Znanost in ?port","doi-asserted-by":"publisher","award":["5442-15\/2016\/18"],"award-info":[{"award-number":["5442-15\/2016\/18"]}],"id":[{"id":"10.13039\/501100005989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["L7-7566"],"award-info":[{"award-number":["L7-7566"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["P2-0232"],"award-info":[{"award-number":["P2-0232"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["P3-0314"],"award-info":[{"award-number":["P3-0314"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Efficient stent implantation among others depends on avoiding the aggregation of platelets in the blood vessels and appropriate proliferation of endothelial cells and controlled proliferation of smooth muscle cells, which reduces the development of pathology, such as neointimal hyperplasia, thrombosis, and restenosis. The current article provides an elegant solution for prevention of platelet and smooth muscle cell adhesion and activation on stent surfaces while obtaining surface conditions to support the growth of human coronary artery endothelial cells. This was achieved by surface nanostructuring and chemical activation of the surface. Specific nanotopographies of titanium were obtained by electrochemical anodization, while appropriate chemical properties were attained by treatment of titanium oxide nanotubes by highly reactive oxygen plasma. Surface properties were studied by scanning electron microscopy, atomic force microscopy, and X-ray photoelectron spectroscopy. Wettability was evaluated by measuring the water contact angle. The influence of nanostructured morphology and plasma modification on in vitro biological response with human coronary artery endothelia and smooth muscle cells as well as whole blood was studied. Our results show that a combination of nanostructuring and plasma modification of the surfaces is an effective way to achieve desired biological responses necessary for implantable materials such as stents.<\/jats:p>","DOI":"10.1021\/acsomega.9b04118","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T13:09:32Z","timestamp":1585314572000},"page":"7280-7289","source":"Crossref","is-referenced-by-count":50,"title":["Titanium Dioxide Nanotube Arrays for Cardiovascular\nStent Applications"],"prefix":"10.1021","volume":"5","author":[{"given":"Ita","family":"Junkar","sequence":"first","affiliation":[{"name":"Joz\u030cef Stefan Institute , , Jamova 39 , ,","place":["Ljubljana, Slovenia, SI-1000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukta","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"University of Ljubljana , , Trz\u030cas\u030cka 25 , ,","place":["Ljubljana, Slovenia, SI-1000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-6544","authenticated-orcid":true,"given":"Metka","family":"Benc\u030cina","sequence":"additional","affiliation":[{"name":"Joz\u030cef Stefan Institute , , Jamova 39 , ,","place":["Ljubljana, Slovenia, SI-1000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janez","family":"Kovac\u030c","sequence":"additional","affiliation":[{"name":"Joz\u030cef Stefan Institute , , Jamova 39 , ,","place":["Ljubljana, Slovenia, SI-1000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katjus\u030ca","family":"Mrak-Poljs\u030cak","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana , , Vodnikova 62 , ,","place":["Ljubljana, Slovenia, SI-1000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Lakota","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana , , Vodnikova 62 , ,","place":["Ljubljana, Slovenia, SI-1000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snez\u030cna","family":"Sodin-S\u030cemrl","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana , , Vodnikova 62 , ,","place":["Ljubljana, Slovenia, SI-1000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miran","family":"Mozetic\u030c","sequence":"additional","affiliation":[{"name":"Joz\u030cef Stefan Institute , , Jamova 39 , ,","place":["Ljubljana, Slovenia, SI-1000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ales\u030c","family":"Iglic\u030c","sequence":"additional","affiliation":[{"name":"University of Ljubljana , , Trz\u030cas\u030cka 25 , ,","place":["Ljubljana, Slovenia, SI-1000"]},{"name":"University of Ljubljana , , Vrazov trg 2 , ,","place":["Ljubljana, Slovenia, SI-1000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"2026082008151323700_cit1","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1093\/cvr\/cvt115","article-title":"Biological\nresponses in stented arteries","volume":"99","author":"Chaabane","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"2026082008151323700_cit2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1161\/CIRCINTERVENTIONS.115.003272","article-title":"Early Stent Thrombosis and Mortality\nAfter Primary Percutaneous Coronary Intervention in ST-Segment-Elevation\nMyocardial Infarction A Patient-Level Analysis of 2 Randomized Trials","volume":"9","author":"Dangas","year":"2016","journal-title":"Circ.: Cardiovasc. Interventions"},{"key":"2026082008151323700_cit3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1159\/000431356","article-title":"The Dual Antiplatelet\nTherapy Trial after the FDA Update: Noncardiovascular Deaths Cancer\nand Optimal Treatment Duration","volume":"132","author":"Serebruany","year":"2015","journal-title":"Cardiology."},{"key":"2026082008151323700_cit4","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.addr.2006.01.016","article-title":"Mechanisms of controlled drug release from drug-eluting stents","volume":"58","author":"Acharya","year":"2006","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026082008151323700_cit5","first-page":"295","article-title":"The randomised study of the double\ndose versus single dose sirolimus-eluting stent for the treatment\nof diabetic patients with de novo coronary lesions","volume":"2","author":"Costa","year":"2006","journal-title":"EuroIntervention : J. EuroPCR Collab. Work. Group Interventional\nCardiol. Eur. Soc. Cardiol."},{"key":"2026082008151323700_cit6","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1016\/S0142-9612(01)00297-6","article-title":"Analysis of a phosphorylcholine-based\npolymer coating on a coronary stent pre- and post-implantation","volume":"23","author":"Lewis","year":"2002","journal-title":"Biomaterials"},{"key":"2026082008151323700_cit7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jvs.2007.02.048","article-title":"Novel thromboresistant\nmaterials","volume":"45","author":"Jordan","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"2026082008151323700_cit8","unstructured":"Malik, S. M.; Mukherjee, A.\n          Implantable medical\ndevice i.e. stent, for treating blood vessel occlusions, has titanium\nnitride carbide compound implanted at predetermined depth within region\nof tissue-contacting surface. 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Technol., A"},{"key":"2026082008151323700_cit36","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/jbm.820260305","article-title":"THE MECHANISMS OF PASSIVE DISSOLUTION OF TITANIUM IN\nA MODEL PHYSIOLOGICAL ENVIRONMENT","volume":"26","author":"Healy","year":"1992","journal-title":"J. Biomed.\nMater. Res."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.9b04118","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/5\/13\/7280\/6186833\/ao9b04118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/5\/13\/7280\/6186833\/ao9b04118.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:45:20Z","timestamp":1787229920000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/5\/13\/7280\/606798\/Titanium-Dioxide-Nanotube-Arrays-for"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,27]]},"references-count":38,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2020,3,27]]},"published-print":{"date-parts":[[2020,4,7]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.9b04118","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,27]]}}}